Sodium Cromoglycate Mucoadhesive Buccal Patches: Design, Fabrication, in Vitro and in Vivo Characterization

Sabry, Shereen A.

doi:10.22159/ijap.2018v10i2.24333

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…The results of inclusion of this drug in buccal patches led to extension of the time required to attain maximum concentration in the blood in addition to showing a reduction in the maximum plasma concentration in the blood. It also provided controlled release of the drug [100].…”

Section: Asthmamentioning

confidence: 99%

Buccal Film: A Novel Approach for Oral Mucosal Drug Delivery System

Haju¹,

Yadav²,

BAIG³

et al. 2021

Asian J Pharm Clin Res

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Buccal drug delivery especially refers to the delivery of drugs through the buccal mucosal membrane lining of the oral cavity. For geriatric and pediatric patients who undergo difficulties in swallowing conventional oral solid dosage forms, the buccal film is a better alternative. The buccal film is appropriate for the drugs which experience high first-pass metabolism and is used for enhancing bioavailability with reducing dosing frequency to mouth plasma peak levels, which thus limit side-effects and make it cost-effective. It enhances the efficacy of API in the oral cavity after the contact with less saliva as contrasted to tablets, without chewing and no need for water for administration. This review briefly describes the advantages and limitations of buccal film, an anatomical structure of oral mucosa, highlighting the mechanisms of drug permeation, formulation technologies, methodology in evaluating buccal film, and recent advances of the buccal film as a tool for drug delivery for various treatments.

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Section: Asthmamentioning

confidence: 99%

Buccal Film: A Novel Approach for Oral Mucosal Drug Delivery System

Haju¹,

Yadav²,

BAIG³

et al. 2021

Asian J Pharm Clin Res

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“…This small size of the polymeric buccal patch makes them more convenient and more comfortable for the user and hence increases the patient compliance. An ideal buccal polymeric patch should be flexible and ellipsoid in the shape so that it can fit easily onto the centre of buccal mucosa [112].…”

Section: Polymeric Patchesmentioning

confidence: 99%

Overview of Mucoadhesive Biopolymers for Buccal Drug Delivery Systems

et al. 2019

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Mucoadhesive dosage forms may be intended for facilitation of prolonged retention time at the application site hence providing drug release in a controlled rate for enhanced improvement of therapeutic activity and its outcome. The buccal mucosa has been investigated for systemic drug delivery and local drug treatment or therapy that is subjected to first pass metabolism. The applicability of bio-adhesion approach in buccal drug delivery proved great therapeutic potential to overcome the limitation of conventional buccal drug delivery. The delivery via buccal route using mucoadhesive biopolymers such as various natural gums e.g. carrageenans, gum karaya, gum arabic, locust bean gum, khaya gum, gum ghatti, albizia gum, guar gum, starch, cellulose, larch gum and pectin etc. and various thiolated and carboxymethylated polymers has been the subject of interest since the early 20th century. The present article is focused mainly on the oral mucosa, mechanism of drug permeation, and characteristics of the desired polymers, the manuscript then proceeds to cover the theories behind the adhesion of bioadhesive polymers to the mucosal epithelium followed by the factors affecting mucoadhesion. Further the author has also discussed on the new generation of mucoadhesive polymers and their properties, recent mucoadhesive formulations for enhanced buccal drug delivery, various marketed products and patent literature. Various online search engines and scientific journals were employed for the collection of literature and scientific data and information related to the topic using keywords like mucoadhesive polymers, buccal drug delivery, buccal patches, tablets, films, gels, powder from the year 2002 and above.

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“…The buccal mucosa was stored in phosphate buffer (pH 6.8) before use. The mucoadhesion study of dental gel formulation was studied using CT3 texture analyser [33][34][35][36][37].…”

Section: In Vitro Mucoadhesion Measurementmentioning

confidence: 99%

Formulation and Evaluation of an Antimicrobial Mucoadhesive Dental Gel of Azadirachta Indica and Glycyrrhiza Glabra

2019

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Objective: Objective of this study was to formulate and evaluate an antimicrobial mucoadhesive dental gel of herbal drugs for the prevention and treatment of dental plaque, dental caries, and periodontitis.Methods: Azadirachta indica leaves extract was prepared with ethanol: water (80:20 v/v) and Glycyrrhiza glabra roots extract was prepared with ethanol: water (30:70 v/v). Both the extracts were evaluated for organoleptic properties, pH, phytochemical screening and total phenolic content. Thin layer chromatography (TLC) and Reverse-phase high-performance liquid chromatography (RP-HPLC) studies were performed. Antibacterial activity of the extract was done on Mueller Hinton agar media against Streptococcus mutans using the disc diffusion method. A mucoadhesive gel was prepared using carbopol 934, polyethylene glycol (PEG) 400 as a bioadhesive polymer and penetration enhancer, respectively. Three gel formulations were prepared at various concentrations of carbopol 934. Dental gel formulations were evaluated for different parameters such as appearance, pH, viscosity, spreadabilty, syringeability. Optimised batch was used for further studies viz. stability study, drug content, diffusion study to determine percent cumulative release of drug from gel formulation and in vitro mucoadhesion study.Results: Rf value of nimbin and glycyrrhizin in TLC study, were found to be 0.08 and 0.56, respectively. RP-HPLC method was developed for estimation of active constituents present in both extracts using mobile phase acetonitrile: water [containing 0.1 % v/v glacial Acetic acid (GAA)]: methanol in the ratio of 30:60:10 at the flow rate of 0.8 ml/min. Rt Conclusion:The evaluation parameters of optimized batch indicate the prepared dental gel is mucoadhesive, stable, good delivery drug system containing antimicrobial agents for prevention of plaque formation, dental caries and periodontitis. of active constituents from both drug extracts was found to be 3.119 and 4.15 min, respectively. 2.5 % w/v of Azadirachta indica leaves extract showed a good zone of inhibition (10.66±0.577 mm) near to chlorhexidine (11.33±0.5773 mm). 1 % of Glycyrrhiza glabra roots extract exhibit antibacterial activity (9±1 mm) and masks the bitter taste of formulation. Batch (F2) was selected on the basis of viscosity, spreadabilty and syringeability. The optimised batch was found to be stable and has 83 % and 80.3 % of drug content. Percent cumulative releases of the drug from gel formulation during the diffusion study were found to be 87.52 % and 85.43 %. Adhesive force and adhesiveness were found to be 11.90 g and 0.92 millijoule, respectively during mucoadhesion study.

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Sodium Cromoglycate Mucoadhesive Buccal Patches: Design, Fabrication, in Vitro and in Vivo Characterization

Cited by 5 publications

References 11 publications

Buccal Film: A Novel Approach for Oral Mucosal Drug Delivery System

Buccal Film: A Novel Approach for Oral Mucosal Drug Delivery System

Overview of Mucoadhesive Biopolymers for Buccal Drug Delivery Systems

Formulation and Evaluation of an Antimicrobial Mucoadhesive Dental Gel of Azadirachta Indica and Glycyrrhiza Glabra

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