Sodium chloride–enriched Diet Enhanced Inflammatory Cytokine Production and Exacerbated Experimental Colitis in Mice

Monteleone, Ivan; Marafini, Irene; Dinallo, Vincenzo; Fusco, Davide Di; Troncone, Edoardo; Zorzi, Francesca; Laudisi, Federica; Monteleone, Giovanni

doi:10.1093/ecco-jcc/jjw139

Cited by 81 publications

(79 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[8–11] In this report, we observed that compared to mice on a regular salt diet, mice on a low salt diet had reduced bleomycin-induced inflammation, lung damage, and fibrosis. These data suggest that low dietary NaCl may attenuate pulmonary fibrosis.…”

Section: Discussionmentioning

confidence: 94%

“…[6,7] High intake of dietary salt (NaCl) has been implicated as a factor that promotes chronic inflammation and fibrosis in both cardiovascular and renal disease. [8–11] The mechanisms by which elevated dietary NaCl promotes disease apart from elevated blood pressure are diverse, and appear to include endothelial cell damage, alterations in the sympathetic nervous system which regulates the cardiovascular and renal systems, and enhanced inflammatory responses. [7,10,12,13] High NaCl promotes inflammatory responses in vitro and in vivo by inhibiting anti-inflammatory regulatory T cells (Treg), promoting pro-inflammatory Th17 T cells, and enhancing production of inflammatory cytokines.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary NaCl affects bleomycin-induced lung fibrosis in mice

Chen

Pilling

2017

Experimental Lung Research

View full text Add to dashboard Cite

Purpose High levels of NaCl in the diet are associated with both cardiac and renal fibrosis, but whether salt intake affects pulmonary fibrosis has not been examined. Aim of the Study To test the hypothesis that salt intake might affect pulmonary fibrosis. Materials and Methods Mice were fed low, normal, or high salt diets for 2 weeks, and then treated with oropharyngeal bleomycin to induce pulmonary fibrosis, or oropharyngeal saline as a control. Results As determined by collagen staining of lung sections, and protein levels and cell numbers in the bronchoalveolar lavage (BAL) fluid at 21 days after bleomycin, the high salt diet did not exacerbate bleomycin-induced fibrosis, while the low salt diet attenuated fibrosis. For the bleomycin-treated mice, staining of the post-BAL lung sections indicated that compared to the regular salt diet, high salt increased the number of Ly6c-positive macrophages and decreased the number of CD11c and CD206-positive macrophages and dendritic cells. The low salt diet caused bleomycin-induced leukocyte numbers to be similar to control saline-treated mice, but reduced numbers of CD45/collagen-VI positive fibrocytes. In the saline controls, low dietary salt decreased CD11b and CD11c positive cells in lung sections, and high dietary salt increased fibrocytes. Conclusions Together, these data suggest the possibility that a low salt diet might attenuate pulmonary fibrosis.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Dietary NaCl affects bleomycin-induced lung fibrosis in mice

Chen

Pilling

2017

Experimental Lung Research

View full text Add to dashboard Cite

show abstract

“…However, we did not observe an elevated salt intake in patients with active disease. Since animal studies showed a negative effect of sodium chloride on inflammation markers in experimental colitis [56], IBD patients should be informed about an adequate salt consumption to prevent additional negative effects.…”

Section: Food Group Hc Total Ibd Ibd (Intake In [G/d]) CD Ucmentioning

confidence: 99%

Dietary Habits and Nutrient Intake in Patients with Inflammatory Bowel Disease

Schink¹,

Mirsch²,

Dieterich³

et al. 2017

J Nutr Food Sci

View full text Add to dashboard Cite

Patients with inflammatory bowel diseases (IBD) are often affected by nutrient deficiencies. Besides a limited nutrient intake by disease-related side effects and malabsorption, the influence of diets and dietary changes is much discussed. However, data about food patterns are mostly based on subjective declarations. Therefore, this study aimed to achieve a detailed and objective analysis of nutrient intake and individual food habits in IBD, a prerequisite for an appropriate nutritional intervention in risk patients. One hundred IBD patients (n=70 Crohn's disease (CD), n=30 ulcerative colitis (UC)) and 30 healthy controls (HC) were included in the study. All participants filled in a disease-related and food frequency questionnaire. Fifteen healthy controls and 71 IBD patients additionally completed a questionnaire for self-imposed food restrictions. Most IBD patients and healthy controls showed a normal body mass index. However, within the IBD group, UC patients were more often overweight than CD patients (p=0.007). Food restrictions were common in all participants, but significantly more IBD patients restricted their consumption of fast food (p=0.037), fruits and vegetables (p=0.019). Especially CD patients with acute relapse consumed less fruits and vegetables (p=0.035). Contrary to subjective assessment, an objective survey of dietary intake revealed a significantly higher sugar intake of IBD patients compared to healthy controls (p<0.001) with an increased ingestion of sugar/confectionery (p=0.041), soft/isotonic drinks (p<0.001) and fruit/vegetable juices (p=0.022). Additionally, IBD patients ingested higher amounts of salt than healthy controls (p=0.005). Both groups showed an insufficient ingestion of folate, vitamin D and pantothenic acid.In conclusion, self-managed food restrictions appear to be common in IBD patients. The huge discrepancy between the subjective view of dietary habits and objective evaluation of nutrient intake indicates that nutrient assessment should be based on objective tools. A repetitive professional nutritional counseling is recommended to prevent and treat nutritional deficiencies.

show abstract

“…Mice that received high salt diet (4%) developed a more severe colitis than controls when exposed to trinitrobenzene-sulfonic acid (TNBS) or DSS [63]. Sodium chloride was found to induce T H 17 cells characterized by up-regulation of TNF-α [64,65].…”

Section: Resultsmentioning

confidence: 99%

Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease

2017

View full text Add to dashboard Cite

We wanted to investigate the current knowledge on the impact of diet on anti-TNF response in inflammatory bowel diseases (IBD), to identify dietary factors that warrant further investigations in relation to anti-TNF treatment response, and, finally, to discuss potential strategies for such investigations. PubMed was searched using specified search terms. One small prospective study on diet and anti-TNF treatment in 56 patients with CD found similar remission rates after 56 weeks among 32 patients with good compliance that received concomitant enteral nutrition and 24 with poor compliance that had no dietary restrictions (78% versus 67%, p = 0.51). A meta-analysis of 295 patients found higher odds of achieving clinical remission and remaining in clinical remission among patients on combination therapy with specialised enteral nutrition and Infliximab (IFX) compared with IFX monotherapy (OR 2.73; 95% CI: 1.73–4.31, p < 0.01, OR 2.93; 95% CI: 1.66–5.17, p < 0.01, respectively). In conclusion, evidence-based knowledge on impact of diet on anti-TNF treatment response for clinical use is scarce. Here we propose a mechanism by which Western style diet high in meat and low in fibre may promote colonic inflammation and potentially impact treatment response to anti-TNF drugs. Further studies using hypothesis-driven and data-driven strategies in prospective observational, animal and interventional studies are warranted.

show abstract

Sodium chloride–enriched Diet Enhanced Inflammatory Cytokine Production and Exacerbated Experimental Colitis in Mice

Abstract: Our data indicated that exposure of intestinal mononuclear cells to a high-NaCl diet enhanced effector cytokine production and contributed to the exacerbation of experimental colitis in mice.

Cited by 81 publications

References 29 publications

Dietary NaCl affects bleomycin-induced lung fibrosis in mice

Dietary NaCl affects bleomycin-induced lung fibrosis in mice

Dietary Habits and Nutrient Intake in Patients with Inflammatory Bowel Disease

Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease

Contact Info

Product

Resources

About