Sodium/calcium overload and Sirt1/Nrf2/OH-1 pathway are critical events in mercuric chloride-induced nephrotoxicity

Li, Siwen; Jiang, Xia; Luo, Yonghong; Zhou, Bingru; Shi, Minmin; Liu, Fangyuan; Sha, Ailong

doi:10.1016/j.chemosphere.2019.06.095

Cited by 27 publications

(8 citation statements)

References 51 publications

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“…At rest, the formed Kepl‐Nrf2 dimer locates in the cytoplasm. When stimulated by reactive oxygen species or external oxidative stress signals, Nrf2 is phosphorylated and translocated into the nucleus, where it exerts the antioxidant activity via activating the expression of downstream OH‐1 and SOD (Li et al., 2019). In the present study, the expression levels of Nrf‐2 and HO‐1 in the liver tissue of T2DM with NAFLD mice were significantly reduced, which may be the key factor leading to the injury and apoptosis of hepatocytes.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of celastrol on type 2 diabetes mellitus with nonalcoholic fatty liver disease in mice

Sun

Wang

et al. 2020

Food Science & Nutrition

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Section: Discussionmentioning

confidence: 99%

Protective effect of celastrol on type 2 diabetes mellitus with nonalcoholic fatty liver disease in mice

Sun

Wang

et al. 2020

Food Science & Nutrition

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“…Jin et al found that rutaecarpine can increase the transcriptional activity of Nrf2 and Nrf2 target genes, HO-1 and NAD(P)H quinone oxidoreductase 1 (NQO1), thereby promoting the phosphorylation of AKT and Ca 2+ /calmodulin-dependent protein kinase-II (CaMKII) [8]. Li et al demonstrated that HgCl 2 increases the expression of Nrf2, HO-1, and NQO1, and induces apoptosis by inducing Na + / Ca 2+ overload and ATPase inactivation in mice, providing a new idea for studying the regulatory effect of Ca 2+ ions and the molecular regulation of the Nrf2-mediated antioxidant pathway [9]. Guidarelli et al found that inhibiting excessive Ca 2+ influx into the mitochondria could prevent arseniteinduced cardiolipin oxidation and DNA single strand breakage, which in turn inhibits the survival signal of Nrf2 [10].…”

Section: Nrf2/ho-1 Signaling Axis In Regulating Internal Flow Of Calcmentioning

confidence: 99%

The Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases

Zhang

Lei

et al. 2020

Cardiology Research and Practice

109

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Cardiovascular disease, which can lead to angina and shortness of breath, remains one of the most serious threats to human health. Owing to its imperceptible symptoms, it is difficult to determine the pathogenesis and treatment methods for cardiovascular disease. Nuclear factor erythropoietin-2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) is a protein found in all cells of the human body. It is activated, transferred to the nucleus, and bound to DNA by antioxidant response elements (AREs). As a regulator of the antioxidant system, it upregulates the expression of HO-1 to reduce oxidative stress. Nrf2/HO-1 also has the ability to modulate calcium levels to prevent ferroptosis, pyroptosis, autophagy, programmed cell necrosis, alkaliptosis, and clockophagy. In view of the importance of Nrf2/HO-1 in the regulation of homeostasis, this review summarizes current research on the relationship between cardiovascular disease and Nrf2/HO-1. Normal cardiovascular diseases, such as viral myocarditis and myocardial ischemia-reperfusion injury, have been treated with Nrf2/HO-1. Rheumatic heart disease, cardiac tumors, arteriosclerosis, arrhythmia, hypertensive heart disease, and myocardial infarction have also been treated during experiments. Research has demonstrated the clinical application of Nrf2/HO-1 in pediatric cardiovascular disease; further clinical trials will help elucidate the potential of the Nrf2/HO-1 signaling axis.

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“…The accumulation of heavy metals can lead to environmental pollution and multiple organ toxicity in humans. Related studies have shown that the Nrf2 pathway is related to AKI induced by heavy metals (such as mercury, chromium, and cadmium), such as upregulating the expression of the HO‐1 and NQO1 genes in the Nrf2 pathway can inhibit AKI induced by mercury chloride; Nrf2 activator curcumin can induce the expression of Nrf2 and reduce the renal damage of chromium to rats (Calderón et al., 2003, S. W. Li et al., 2019, Molina‐Jijón et al., 2011).…”

Section: The Protective Effect Of Nrf2 On Acute Kidney Injurymentioning

confidence: 99%

Protection against acute renal injury by naturally occurring medicines which act through Nrf2 signaling pathway

Wang

Luo

et al. 2020

J. Food Biochem.

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The cellular defense pathway plays a key role in maintaining the homeostasis, tissues and organisms. Nuclear factor E2-related factor 2 (Nrf2), as a key cell signaling pathway, plays an important role in encoding detoxification enzymes and other stress response mediators. Recent studies have shown that it is closely related to the prevention and treatment of acute kidney injury (AKI). Therefore, this article reviews the protective effects of Nrf2-related signaling pathways on acute kidney injury, and summarizes the strategies of natural pharmaceutical ingredients such as flavonoids, alkaloids, terpenes, phenylpropionic acid, polyphenols, and polysaccharides to prevent and treat acute kidney injury. It is of great significance to further study the relationship between Nrf2 regulated signal pathway and kidney disease and the development of new medicines for acute kidney injury treatment. It can also provide new ideas and treatment strategies for clinical treatment of acute kidney injury. Practical applications This article reviewed the mechanisms by which the active ingredients of natural medicines slow down acute kidney injury through the Nrf2 pathway. It will help us to understand the regulatory role of the Nrf2 pathway in AKI more comprehensively, and provide a theoretical basis for further exploring the mechanism of more natural drugs to reduce acute kidney injury.

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Sodium/calcium overload and Sirt1/Nrf2/OH-1 pathway are critical events in mercuric chloride-induced nephrotoxicity

Cited by 27 publications

References 51 publications

Protective effect of celastrol on type 2 diabetes mellitus with nonalcoholic fatty liver disease in mice

Protective effect of celastrol on type 2 diabetes mellitus with nonalcoholic fatty liver disease in mice

The Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases

Protection against acute renal injury by naturally occurring medicines which act through Nrf2 signaling pathway

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