Protection against acute renal injury by naturally occurring medicines which act through Nrf2 signaling pathway

Abstract

The cellular defense pathway plays a key role in maintaining the homeostasis, tissues and organisms. Nuclear factor E2-related factor 2 (Nrf2), as a key cell signaling pathway, plays an important role in encoding detoxification enzymes and other stress response mediators. Recent studies have shown that it is closely related to the prevention and treatment of acute kidney injury (AKI). Therefore, this article reviews the protective effects of Nrf2-related signaling pathways on acute kidney injury, and summarizes the strategies of natural pharmaceutical ingredients such as flavonoids, alkaloids, terpenes, phenylpropionic acid, polyphenols, and polysaccharides to prevent and treat acute kidney injury. It is of great significance to further study the relationship between Nrf2 regulated signal pathway and kidney disease and the development of new medicines for acute kidney injury treatment. It can also provide new ideas and treatment strategies for clinical treatment of acute kidney injury. Practical applications This article reviewed the mechanisms by which the active ingredients of natural medicines slow down acute kidney injury through the Nrf2 pathway. It will help us to understand the regulatory role of the Nrf2 pathway in AKI more comprehensively, and provide a theoretical basis for further exploring the mechanism of more natural drugs to reduce acute kidney injury.

Sesamin Protects against and Ameliorates Rat Intestinal Ischemia/Reperfusion Injury with Involvement of Activating Nrf2/HO‐1/NQO1 Signaling Pathway

“…Pathway in Protecting against Intestinal I/R Injuries. The protective role of Nrf2 activation with involvement of its downstream pathways such as HO-1 and NQO1 is characterized by inhibiting inflammation, oxidative stress, and apoptosis [29][30][31], which are involved in ameliorating kidney [32], brain [33], and myocardial injuries [34]. 3.5.2.…”

Antioxidant Effect of Chrysanthemum morifolium (Chuju) Extract on H2O2-Treated L-O2 Cells as Revealed by LC/MS-Based Metabolic Profiling

“…A lot of natural compounds including alkaloids, phenolics, and terpenes in chrysanthemum have been identified as antioxidants [ 6 ]. For them, the predominant effects may involve the activation of Nrf2-related antioxidant pathways and scavenging of free radicals [ 7 , 8 , 9 ]. However, researchers found that the biological activities of natural extracts are much higher than those of single bioactive molecules due to the interaction between molecules at pharmacodynamic and pharmacokinetic levels, suggesting that the synergistic effect between multiple compounds cannot be overlooked [ 10 ].…”