Sodium benzoate-induced repeated episodes of acute urticaria/angio-oedema: randomized controlled trial

Abstract

This study shows that the percentage of repeated episodes of acute urticaria/angio-oedema reactions induced by sodium benzoate is very low (2%). In view of our results, we suggest that when faced with patients who have suffered adverse reactions that could be attributed to sodium benzoate, physicians should also carefully evaluate other possible causes.

The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update

“…Podobnie jak w przypadku leków, pseudoalerge ny mogą zarówno wywoływać, jak i nasilać już ist niejące objawy PPS [92]. W takich przypadkach na leży wprowadzić i utrzymać przez przynajmniej 3-6 miesięcy dietę zawierającą jedynie małe dawki natu ralnych i sztucznych pseudoalergenów.…”

Estimated Daily Intake of Benzoic Acid through Food Additives in Adult Population of South East Serbia

“…Some studies suggested that very high intake of benzoic acid can cause adverse health effects such as metabolic acidosis, hyperpnoea and convulsions (1). Few epidemiologic studies reported allergic reactions to benzoic acid and benzoate (urticaria, rinhitis and pruritis) (3)(4)(5). For this reason, estimation of daily intake of these additives is of public health concern.…”

Estimation of Food Additive Intake—Overview of the Methodology

“…(73) In a double-blind placebo-controlled challenge performed on 47 patients, subjects developed acute urticaria/angiodema suspected to be induced by sodium benzoate containing foods. (74) A single case of recurrent anaphylaxis was reported, occurring after eating takeout food. Another double-blind placebo-controlled trial that involved a challenge with 25 mg each of sodium nitrate and sodium nitrite resulted in an acute anaphylactic reaction.…”

“…MPLs were used in case of some studies. (41,74,75,76,77) Mostly national dietary data on food consumption were used. The dietary survey tools used were 24-hour recall, semiquantitative FFQ, and food diary.…”