This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesive buccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatin from bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharmaceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride (PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higher elastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higher adhesion strength, while GAP shows higher work of adhesion. Both in vitro release study and in silico simulation indicated that processed films can provide effective drug transport through the buccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparison to the immediate-release tablets—indicating that the therapeutic drug dose can be markedly reduced.
Alumina fillers having different morphologies were used for reinforcement of PMMA-based composite materials. The employed fillers had the same chemical composition but morphologically were spherical nanoparticles, whiskers and an electrospun product that was composed of micro-sized mostly spherical particles and nanofibers. The electrospun product was obtained from aluminum chloride hydroxide/PVA/water solution. All fillers were added without surface treatment and mechanical characteristics of obtained composites were determined using dynamic mechanical analysis (DMA) and nanoindentation. From the nanoindentation results, the reduced elastic modulus for the obtained specimens using 3 wt.% of electrospun product was 134% of the one obtained with the polymer alone and the hardness was improved to 157.8% compared to the polymer without any additive. DMA shows that the storage modulus at room temperature was twice that of the polymer alone.
Highlights Cellulose acetate films were impregnated with thymol using supercritical CO2 Target thymol contents for desired antibacterial activity were in the range 26-30% Thymol prevented S. aureus and P. aeruginosa attachment to films' surfaces Released thymol reduced biofilm formation on the surrounding surfaces The films showed strong anti-biofilm activity against antibiotic resistant strains Graphical abstarct
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