Sodium alginate and gelatin hydrogels: Viscosity effect on hydrophobic drug release

Bhutani, Utkarsh; Laha, Anindita; Mitra, Kishalay; Majumdar, Saptarshi

doi:10.1016/j.matlet.2015.10.114

Cited by 58 publications

(31 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4. c) a new band formed at 1612 cm -1 is assigned to C=N stretching vibrations which indicates the interaction between-OH group of SA and NH2 group of GE which confirms the formation of microbeads [36]. The FTIR spectra of pristine D-PA ( fig.…”

Section: Intercalation Kineticsmentioning

confidence: 82%

See 1 more Smart Citation

Sodium Alginate/Gelatin Microbeads-Intercalated With Kaolin Nanoclay for Emerging Drug Delivery in Wilson’s Disease

et al. 2019

View full text Add to dashboard Cite

Objective: The aim of the present study was to fabricate and evaluate the drug release studies using Sodium Alginate (SA) and Gelatin (GE) microbeads intercalated with Kaolin (KA) nanoclay for sustained release of D-Penicillamine (D-PA). Methods: Sodium alginate/gelatin/Kaolin blend microbeads were prepared by an extrusion method by using glutaraldehyde (GA) as a crosslinker. The obtained microbeads were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and X–ray diffraction (XRD). Drug release kinetics of the microbeads was investigated in simulated intestinal fluid (pH 7.4) at 37 °C. Results: Microbeads formation was confirmed by FTIR spectroscopy. X-RD reveals that the KA should be intercalated with the drug and also it confirms the molecular level dispersion of D-Penicillamine into microbeads. Scanning Electron Microscopy (SEM) studies reveal that the beads were in spherical shape with some wrinkled depressions on the surface. The in vitro release study indicates the D-Penicillamine released in a controlled manner. The in vitro release kinetics was assessed by Korsmeyer-Peppas equation and the ‘n’ value lies in between 0.557-0.693 indicates Non-Fickian diffusion process. Conclusion: The results suggest that the developed KA intercalated microbeads are good potential drug carrier for the controlled release of D-PA.

show abstract

Section: Intercalation Kineticsmentioning

confidence: 82%

“…A few articles have been reported the combination of SA and GE for controlled drug delivery [34][35][36][37], but as per best of our knowledge, the use of SA/GE/KA microbeads for controlled release of D-PA has not yet been investigated. In this research paper KA intercalated SA/GE microbeads were prepared.…”

Section: Introductionmentioning

confidence: 99%

Sodium Alginate/Gelatin Microbeads-Intercalated With Kaolin Nanoclay for Emerging Drug Delivery in Wilson’s Disease

et al. 2019

View full text Add to dashboard Cite

show abstract

“…XRD spectra were recorded on a Ultima-IV X-ray diffractometer (Rigaku, Japan). 3. Results and discussion The samples were prepared in a dumbbell shape ( Fig.…”

Section: Materials Characterizationmentioning

confidence: 99%

“…Addition of crosslinking agents can improve material strength and stability. To develop sustainable and biodegradable SAP, a natural cross-linking agent is more favorable than chemicals from petrochemical industry [3]. Alginate sodium is a natural polysaccharide and can be easily cross-linked by 2+ ions [4,5].…”

mentioning

confidence: 99%

Sustainable composite super absorbents made from polysaccharides

Hong

Hui³

2016

Materials Letters

View full text Add to dashboard Cite

Compared to traditional super absorbent polymers using raw materials from petrochemical industry, natural polymer absorbents are more favorable because they are sustainable and biodegradable. In this study, composite absorbents were developed by crosslinking carrageenan with sodium alginate using calcium chloride. Effect of composition on absorption was tested. Absorption was improved by increasing carrageenan content. The super absorbent exhibited the maximal swelling ratio of 13.1 g/g in 0.9% saline water in just 5 minutes. The maximal tensile strength was reached with a value of 12.8 MPa. Water contact angle revealed that carrageenan is more hydrophobic than sodium alginate. Presence of sulfate groups might be a key factor promoting absorption. The scanning electron microscopic images showed that the composite material had a structure with alginate arranged at the outside surface. These results demonstrate that a sustainable and biodegradable absorbent was successfully developed with a matrix of properties for potential application in diapers.

show abstract

“…Gelatin is derived from collagen, a natural protein in the tendons, ligaments, and tissues of mammals. The combined use of these naturally derived hydrogels, such as alginate and gelatin was studied for controlled release and tissue engineering applications . Yang and Jones showed that alginate can trigger macrophage activity and increases cytokine levels in wounds.…”

Section: Introductionmentioning

confidence: 99%

Alginate‐gelatin blend with embedded voids for controlled release applications

Banerjee

Patra

Ganguly

2017

J of Applied Polymer Sci

View full text Add to dashboard Cite

Alginate gel is known for its potential use in the controlled release of drugs, and as a 3-D structure for tissue harvesting. In this paper, the tuning of the performance of alginate gel by blending gelatin in the aqueous phase, and introducing bubbles in a regular alignment are discussed. Monodisperse bubbles in millimetre or submillimeter size were introduced into the aqueous suspension of the blend prior to gelation, using a novel fluidic arrangement. The CaCl 2 solution, added as the crosslinker diffused into the lamella, forming a rigid structure of calcium alginate. The effective blending of gelatin in alginate provided benefits of both the biopolymers in the final product. The benefits are the excellent absorption capacity of alginate and the mechanical strength of gelatin in the blend. The selfaligned voids enabled further tuning of absorption capacity and/or rate of release. Also, the presence of voids enhanced the elastomeric quality of the composite structure. The uptake of Vitamin B 12 solution was measured gravimetrically, and the release in PBS buffer on a shaker was studied using UV-vis spectrophotometer. For different loadings of void and gelatin, the absorption capacity, mechanical strength and the compression behavior were analysed.

show abstract

Sodium alginate and gelatin hydrogels: Viscosity effect on hydrophobic drug release

Cited by 58 publications

References 10 publications

Sodium Alginate/Gelatin Microbeads-Intercalated With Kaolin Nanoclay for Emerging Drug Delivery in Wilson’s Disease

Sodium Alginate/Gelatin Microbeads-Intercalated With Kaolin Nanoclay for Emerging Drug Delivery in Wilson’s Disease

Sustainable composite super absorbents made from polysaccharides

Alginate‐gelatin blend with embedded voids for controlled release applications

Contact Info

Product

Resources

About