Sodium 3,5,6-trichloropyridin-2-ol poisoning

Abstract

Sodium 3,5,6-trichloropyridin-2-ol (STCP) is an important intermediate for synthesizing organophosphate insecticide chlorpyrifos. At present, chlorpyrifos is one of the world's largest species of pesticide products. Many studies have focused on the toxicity of chlorpyrifos, but few reports have looked at the toxicity mechanism of STCP. Even fewer studies have looked at STCP poisoning. With increasing production and usage of STCP, the chances of such poisoning will increase. In this study, we present a report on four workers who helped in the industrial manufacture of STCP and who were affected by exposure to it. We hope that these case studies will provide a foundation for further research into STCP.

Arsenical keratosis coexists with chloracne

“…As early as 1993, Cheng et al surveyed 109 Chinese workers and reported that the prevalence of chloracne was 73.4% (80/109) in total and 95.2% (20/21) in a trichlorobenzene (TCB) tank area where dioxin and dibenzofurans levels were in thousands of ppm [1]. Recently, Wu et al and Niu et al reported that the workers who worked in an STCP factory in China developed chloracne and peripheral nerve damage [2,3]. For pathogenesis investigation, Liu et al found that the activation of mitogen-activated protein kinase pathway and upregulation of CK17 and TGK might play roles in the pathogenesis of chloracne related to dioxin exposures [4].…”