SOCl2/EtOH: Catalytic system for synthesis of chalcones

Pyrrolidine-Mediated Direct Preparation of (E)-Monoarylidene Derivatives of Homo- and Heterocyclic Ketones with Various Aldehydes

“…The electronic properties and steric hindrance of the substituents at the aromatic ring affected the yields strongly (Table 2, entries 1-13). Aromatic aldehydes with electron-withdrawing groups gave higher yields than those with electron-donating groups ( Table 2, entries 2-6, 10, 12, 13 vs. 7,8,11). ortho-Substituted aromatic aldehydes gave higher yields than para-and meta-substituted aromatic aldehydes ( Table 2, entries entries 4, 5, 8 vs. 10-13).…”

“…Thus, the synthesis of these compounds has attracted increasing attention from chemists, biochemists and pharmacologists. So far, several strategies are reported for the preparation of these compounds, which are accomplished by various methods such as condensation, oxidation, elimination, acylation, and insertion of carbon monoxide, among others [7][8][9][10][11][12][13][14][15]. In connection with a project in our laboratory, we required mono-2-arylidene derivatives of ketones, particularly of piperidone.…”

Microwave assisted synthesis of some halosubstituted chalcones

“…Chalcones are also synthesized by using microwave irradiation, ultrasound irradiation [16] and by Suzuki reaction [17]. Various modified methods for synthesis of chalcones has been reported using different catalyst such as SOCl 2 [18], natural phosphate / lithium nitrate [19], KF / natural phosphate [20], acyclic acidic ionic liquid [21], Na 2 CO 3 [22], high-temperature water [23], sodium carbonate [24], ZrCl 4 and ionic liquid [25], Table 1.…”

Microwave‐assisted Synthesis of Novel 3,4‐Bis‐chalcone‐N‐arylpyrazoles and Their Anti‐inflammatory Activity

“…Microwave synthesis offered advantages over conventional heating, due to rapid reaction and improvement in yields, in the synthesis of chalcones. 13,14 The combination of both previous active moieties, pyarazole and chalcone, may provide a synergistic effect to improve the anti-inflammatory activity. These predictions encouraged us to synthesize hybrid compounds containing N-arylpyrazole combined with chalcone scaffold.…”