Socioeconomic Status and Inflammation in Women with Early-stage Breast Cancer: Mediation by Body Mass Index

Pageot, Yrvane K.; Stanton, Annette L.; Ganz, Patricia A.; Irwin, Michael R.; Cole, Steve W.; Crespi, Catherine M.; Breen, Elizabeth C.; Kuhlman, Kate R.; Bower, Julienne E.

doi:10.1016/j.bbi.2021.10.008

Cited by 8 publications

(6 citation statements)

References 90 publications

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“…ANCOVA was used to test the differences between surgery types in post-surgical HRQOL and inflammatory markers while controlling for pre-surgery values and age, stage, and days since surgery. BMI and education were included as covariates for inflammatory marker analyses only given associations between BMI and socioeconomic status on circulating inflammatory markers 45 , 46 . Post hoc pairwise comparisons with Tukey adjustments for multiple comparisons were used to test differences between surgery types (lumpectomy, unilateral mastectomy, bilateral mastectomy) on post-surgery values.…”

Section: Methodsmentioning

confidence: 99%

Acute health-related quality of life outcomes and systemic inflammatory markers following contemporary breast cancer surgery

et al. 2022

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Contemporary breast cancer surgical procedures vary greatly by the amount of tissue removed, anesthesia time, and reconstruction. Despite historical literature comparing the health-related quality of life (HRQOL) after lumpectomy and mastectomy, HRQOL data are limited regarding contemporary surgical procedures. Further, biological processes (e.g., inflammation) associated with HRQOL outcomes have not been described. We conducted two studies to examine differences in post-operative physical and mental functioning, pain, fatigue, and systemic inflammatory markers including interleukin (IL)-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) in women with early-stage breast cancer. Study 1 assessed women before and after surgery (n = 27) and Study 2 used a large cross-sectional sample (n = 240) to confirm findings from Study 1 and included a no-surgery comparison group. In Study 1, women who received mastectomy had lower physical functioning than lumpectomy (ps < 0.05), and those who received bilateral mastectomy had worse pain (p < 0.01) and fatigue (p = 0.029) than lumpectomy. Results were replicated in Study 2: mastectomy groups exhibited poorer physical functioning (ps < 0.01) and greater pain (ps < 0.001) than lumpectomy, and bilateral mastectomy was associated with worse fatigue (p < 0.05). Women who received bilateral mastectomy had higher levels of CRP than lumpectomy (p < 0.01) and higher TNF-α than the no-surgery group (p < 0.05). All surgery groups exhibited higher IL-6 than no-surgery (ps < 0.05). More extensive surgery is associated with poorer postoperative HRQOL. As compared to lumpectomy and no-surgery, mastectomy is associated with higher concentrations of systemic inflammatory markers.

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Section: Methodsmentioning

confidence: 99%

Acute health-related quality of life outcomes and systemic inflammatory markers following contemporary breast cancer surgery

et al. 2022

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“…Additionally, those results about the association between ETS exposure and oral health symptoms by socioeconomic status of female adolescents also can be supported by studies which explained that socioeconomic status could affect women’s inflammation, and immune function [ 27 , 28 ]. Also, the result of stronger association between ETS exposure and oral health symptoms in older adolescents might be result of the cumulative effect, in that, bad oral health is progressive in nature [ 29 , 30 ], and negative effects of ETS also becomes cumulative [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 79%

Associations between environmental tobacco smoke exposure and oral health symptoms in adolescents

et al. 2022

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Background Oral health condition in adolescence impacts the oral well-being throughout life. This study aimed to determine the association between environmental tobacco smoke (ETS) exposure and oral health in adolescents, using nationally representative data. Methods Using data from the 2020 Korea Youth Risk Behavior Web-based Survey, we assessed self-reported data on ETS exposure and oral health symptoms in 37,591 non-smoking adolescents. The dependent variables were self-reported oral health symptoms of adolescents (tooth fracture, dental pain, and gum bleeding). ETS exposure was the primary independent variable. Chi-square tests and multivariable logistic regression analyses were performed to examine these relationships. Results ETS exposure was positively associated with oral symptoms compared to no-ETS exposure in adolescents [boys, odds ratio (OR) 1.56, 95% confidence interval (CI) 1.46–1.66; girls, OR 1.50, 95% CI 1.41–1.60]; individuals with good oral health habits such as frequent tooth brushing [boys, three times or more a day, OR 1.38, 95% CI 1.24–1.53] and less soda consumption [girls, less than once a day, OR 1.73, 95% CI 1.29–2.33] had a weaker association. ETS exposure was positively associated with dental pain [boys, OR 1.55, 95% CI 1.45–1.66; girls, OR 1.50, 95% CI 1.41–1.60] and gum bleeding [boys, OR 1.43, 95% CI 1.29–1.58; girls, OR 1.32, 95% CI 1.21–1.44]; however, tooth fracture was significantly associated only in girls [OR 1.28, 95% CI 1.13–1.45]. Conclusions ETS in various environments is negatively associated with oral health in adolescents. This association could vary depending on health habits. Sophisticated policies to protect South Korean adolescents from ETS can be developed from these findings.

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“…Moreover, the socio-economic status data of enrolled breast cancer patients were not collected. Other studies reported that the socio-economic status of such a group of patients was associated with higher levels of inflammation and poor cancer-related outcomes [ 33 ]. For example, Choi et al found that breast cancer patients with poor socio-economic conditions suffered from higher pain levels than patients with less distressful conditions and concluded that pain management should be tailored to patients’ social determinants [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Care Needs and Symptoms Burden of Breast Cancer Patients in Jordan: A Cross-Sectional Study

Shamieh

Alarjeh

et al. 2022

IJERPH

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Breast cancer is the most common malignancy in Jordan. Rigorous needs assessment for breast cancer patients can prioritize both cancer care and palliative care to propose the appropriate services effectively. We conducted a cross-sectional study of breast cancer patients in a cancer center in Jordan. We assessed symptom burden, comorbidities, and performance using the Edmonton Symptom Assessment System (ESAS), the Charlson Comorbidity Index (CCI), and the Australia-modified Karnofsky performance scale (AKPS). Descriptive analysis and regression models to predict the highest symptom burden were used. A total of 233 participants were enrolled: curative vs. palliative intent groups (147 (63%) vs. 86 (37%) patients), respectively. Tiredness was the most reported symptom in 189 patients (81%), while nausea was the least in 61 patients (26.2%). A relationship between the AKPS score and total ESAS was seen (correlation coefficient of −0.487; p < 0.0001). The prevalence of anxiety (p = 0.014), lack of appetite (p = 0.002), poor well-being (p < 0.001), and sleep disorder (p = 0.035) was higher in the palliative care intent group than in the curative one. We identified unmet needs in breast cancer patients. Both groups showed a prevalence of distressing symptoms suggesting that even those with non-palliative intent have high needs and should receive integrated palliative care.

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Socioeconomic Status and Inflammation in Women with Early-stage Breast Cancer: Mediation by Body Mass Index

Cited by 8 publications

References 90 publications

Acute health-related quality of life outcomes and systemic inflammatory markers following contemporary breast cancer surgery

Acute health-related quality of life outcomes and systemic inflammatory markers following contemporary breast cancer surgery

Associations between environmental tobacco smoke exposure and oral health symptoms in adolescents

Care Needs and Symptoms Burden of Breast Cancer Patients in Jordan: A Cross-Sectional Study

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