Sociodemographic factors and quality of life as prognostic indicators in head and neck cancer

Graeff, Alexander de; Leeuw, J.R.J. de; Ros, W.J.G.; Hordijk, G. J.; Blijham, Geert H.; Winnubst, J.A.M.

doi:10.1016/s0959-8049(00)00385-3

Cited by 175 publications

(152 citation statements)

References 38 publications

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“…10 Similarly, another study identified married status as a positive prognostic factor in patients with squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx and larynx. 11 Several studies have also shown that the risk of mortality in the general population is lower for married patients. [17][18][19] The mechanism for this survival advantage is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7] Racial disparities are becoming increasingly apparent in a variety of head and neck cancers. [8][9][10][11] Few studies have looked specifically at racial disparities in thyroid malignancies. A recent study evaluating the impact of race and ethnicity on thyroid cancer presentation found that African Americans had larger tumours compared with other racial groups.…”

Section: Introductionmentioning

confidence: 99%

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Racial disparities in papillary thyroid microcarcinoma survival

Megwalu

Saini

2016

J. Laryngol. Otol.

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Objective: To evaluate the impact of race on survival in patients with papillary thyroid microcarcinoma.Methods: The study cohort included 17 668 patients diagnosed with papillary thyroid microcarcinoma between 1988 and 2009, identified in the Surveillance, Epidemiology, and End Results 18 database of the National Cancer Institute.Results: Black patients had lower overall survival than other racial groups ( p < 0.001). Black patients had significantly worse overall survival (hazard ratio = 2.59) after adjusting for sex, marital status, age, year of diagnosis, multifocal disease and type of surgery. A subset analysis of Black patients revealed no significant difference in overall survival for total thyroidectomy versus lobectomy ( p = 0.15).Conclusion: Black race is a negative prognostic factor in thyroid cancer, which cannot be explained by advanced disease stage. Further research on mechanisms by which race affects survival is needed to reveal areas of opportunity for interventions aimed at reducing health disparities in cancer care.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Racial disparities in papillary thyroid microcarcinoma survival

Megwalu

Saini

2016

J. Laryngol. Otol.

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“…Health-related quality-of-life prognostic factor analyses have been carried out on several different cancer populations, including, among others, lung (Herndon et al, 1999;Langendijk et al, 2000;Montazeri et al, 2001;Efficace et al, 2006), oesophageal (Blazeby et al, 2001;Fang et al, 2004), advanced breast (Luoma et al, 2003;Efficace et al, 2004a), and head and neck (de Graeff et al, 2001) cancers, highlighting the importance HRQOL scores may have in predicting survival. Only three studies have examined HRQOL and/or cognitive functioning as a prognostic factor in brain cancer (Meyers et al, 2000;Klein et al, 2003;Sehlen et al, 2003).…”

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confidence: 99%

The prognostic value of health-related quality-of-life data in predicting survival in glioblastoma cancer patients: results from an international randomised phase III EORTC Brain Tumour and Radiation Oncology Groups, and NCIC Clinical Trials Group study

et al. 2007

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This is one of the few studies that have explored the value of baseline symptoms and health-related quality of life (HRQOL) in predicting survival in brain cancer patients. Baseline HRQOL scores (from the EORTC QLQ-C30 and the Brain Cancer Module (BN 20)) were examined in 490 newly diagnosed glioblastoma cancer patients for the relationship with overall survival by using Cox proportional hazards regression models. Refined techniques as the bootstrap re-sampling procedure and the computation of C-indexes and R 2 -coefficients were used to try and validate the model. Classical analysis controlled for major clinical prognostic factors selected cognitive functioning (P ¼ 0.0001), global health status (P ¼ 0.0055) and social functioning (Po0.0001) as statistically significant prognostic factors of survival. However, several issues question the validity of these findings. C-indexes and R 2 -coefficients, which are measures of the predictive ability of the models, did not exhibit major improvements when adding selected or all HRQOL scores to clinical factors. While classical techniques lead to positive results, more refined analyses suggest that baseline HRQOL scores add relatively little to clinical factors to predict survival. These results may have implications for future use of HRQOL as a prognostic factor in cancer patients.

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“…Socio-demographic factors have been identified as independent prognostic indicators or along with clinical factors (15,18). Recently, much emphasis has been laid on analyzing these factors and is assumed to be of much value in determining the overall well-being and survival of cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…Socio-demographic factors have been found to be of significance in prognosis of many advanced cancers such as head and neck (15), oral (16) and breast cancer (17,18). However, not many studies have concentrated on the socio-demographic factors for their potential prognostic importance.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological, but not socio-demographic factors affect the prognosis in cervical carcinoma

Munagala

Shesh²,

Ganesarajah³

et al. 2010

Oncol Rep

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Abstract. The purpose of this study was to investigate the prognostic factors, such as clinical, histological and sociodemographic features affecting the event-free and overall survival of the patients with stage I-III carcinoma of the cervix. Eighty-nine patients with International FIGO stage I-III cervical cancer were treated radiation therapy and follow-up of 5-7 years were analyzed for various clinical, histopathological and socio-demographic factors influencing prognosis. Survival estimations were performed using the Kaplan-Meier method, and were compared using the un-weighted log-rank test and multivariable analysis using the Cox proportional hazards model. The median age was 46 years (range, 28-65 years). The 5-year event-free survival (EFS) and overall survival (OAS), along with standard error (SE), were 65.2% (7.0%) and 81.4% (6.1%), respectively. Significant prognostic factors for EFS include, stage (P=0.019), pelvic lymph node metastasis (P=0.013), parametrial (PMT) involvement (P=0.025), number of parametria involved (P=0.000) and tumor size (P=0.034). However, number of parametrial invasion was only significant prognostic factors for overall survival (P=0.015); 5-year survival rate was significantly lower in patients with both PMT involved (58%) than with one PMT involved (>85%). Using a multivariable analysis, we found that number of PMT involved being the only independent significant factor for the development of recurrent disease. None of the socio-demographic factors analyzed were of prognostic importance on event-free and overall survival in cervical cancer patients. Several clinicopathological factors were of prognostic significance but none of the socio-demographic factors analyzed had any role in determining patient outcome. Hence, in cervical cancer, prognosis is more likely dependent on clinical than sociodemographic factors unlike several other cancers where their significant role is well documented. Study of clinical and demographic characteristics for their influence on patient survival could help design better patient management strategies.

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Sociodemographic factors and quality of life as prognostic indicators in head and neck cancer

Cited by 175 publications

References 38 publications

Racial disparities in papillary thyroid microcarcinoma survival

Racial disparities in papillary thyroid microcarcinoma survival

The prognostic value of health-related quality-of-life data in predicting survival in glioblastoma cancer patients: results from an international randomised phase III EORTC Brain Tumour and Radiation Oncology Groups, and NCIC Clinical Trials Group study

Clinicopathological, but not socio-demographic factors affect the prognosis in cervical carcinoma

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