Sociodemographic characteristics, sexual behaviour and knowledge about cervical cancer prevention as risk factors for high-risk human papillomavirus infection in Arkhangelsk, North-West Russia

Abstract

While sociodemographic predictors of cervical cancer (CC) are well understood, predictors of high-risk (HR) human papillomavirus (HPV) infection have not been fully elucidated. This study explored the HR-HPV infection positivity in relation to sociodemographic, sexual behavior characteristics and knowledge about HPV and CC prevention among women who visited the Arkhangelsk clinical maternity hospital named after Samoylova, Russia. This cross-sectional study was conducted in the city of Arkhangelsk, Northwest Russia. Women who consulted a gynecologist for any reason between 1 January 2015 and 30 April 2015 were residents of Arkhangelsk, 25–65 years of age were included. The Mann–Whitney and Pearson’s χ2 tests were used. To determine the HR-HPV status, we used the Amplisens HPV-DNA test. We used a questionnaire to collect the information on sociodemographic factors. Logistic regression was applied. The prevalence of HR-HPV infection was 16.7% (n = 50). HR-HPV infection was more prevalent in younger women, cohabiting, nulliparae, smokers, having had over three sexual partners and early age of sexual debut. The odds of having a positive HR-HPV status increased by 25% with an annual decrease in the age of sexual debut. Moreover women with one child or more were less likely to have positive HR-HPV status.

Genotype Distribution and Prevalence of Human Papillomavirus Among Russian Women in Rostov, Southern Federal District of Russia

“…Younger women had an HPV infection most frequently. Our data correspond to the results of other studies, according to which the peak of HPV detection occurs in age groups of women younger than 30 years old who have the highest sexual activity and change of sexual partners (Zeng et al, 2016;Roik et al, 2018). In the United States population, the prevalence range of HPV positive was in young women under 30 years old, between 41-51% (Karuri et al, 2017).…”

The Prevalence of HPV Genotypes in Iranian Population: An Update

“…No fixed pattern of the HPV genotypes distribution observed even in different parts of a province, e,g, the samples from suburb of Tehran commonly demonstrated mixed infections (the data were not shown). Although no sociodemographic data are available, low education and inappropriate economic conditions may be an explanation, high risk HPV distribution is affected by sexual behavior, host immune factors, environmental factors, smoking, having multiple sex partners, and the presence of other sexually transmitted infections (16). Therefore, HPV as an important transmitted infection causes some critical HPV-associated cancers in human, circulating HPV genotypes should be available to plan better the prevention.…”

Long non‑coding RNA UCA1 enhances cervical cancer cell proliferation and invasion by regulating microRNA‑299‑3p expression

“…Most cases of cervical cancer are caused by HPV infection ( 48 ). Although surgical treatment, chemotherapy and radiotherapy have a therapeutic effect on cervical cancer, this effect is insufficient ( 49 ). Recent studies have reported that lncRNAs play important regulatory roles in cervical cancer ( 50 – 52 ).…”