Socio demographic wise risk assessment of thyroid function abnormalities in far western region of Nepal: A hospital based descriptive study

Yadav, Neelu; Thanpari, C; Shrewastwa, Mukesh Kumar; Sathian, Brijesh; Mittal, Rabindra Kumar

doi:10.1016/s2222-1808(13)60060-2

Cited by 14 publications

(16 citation statements)

References 21 publications

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“…[14] Hyperthyroidism was detected in 9.76% in the present study which was comparable to Aryal M et al [4] A hospital based study carried out by Yadav NK et al in far western region of Nepal, found 24.8% of hyperthyroidism which is much higher than our finding. [7] Another study conducted by Mahato et al in central region of Nepal and Yadav RK et al in western region of Nepal, reported the prevalence of 4% and 4.66% of hyperthyroidism respectively which is much lower than in the present study. [5,6] In present study, the mean age of patients with thyroid dysfunction was found 42.18 yrs (SD = 16.2).…”

Section: Discussioncontrasting

confidence: 70%

“…Baral N et al found that 30% of populations among the hospital patients were affected from thyroid disorder in eastern part of Nepal. [3] Aryal M et al [4] recorded 25% in Kavre, Mahato RV et al [5] reported 29% in central (Kathmandu) Nepal, Yadav RK et al [6] observed 17.42% in Pokhara, and Yadav NK et al [7] found 33.66% in far-western part of Nepal. This variation may be due to ethnic, geographic, and environment factors including iodine intake status as mentioned in other studies.…”

Section: Discussionmentioning

confidence: 99%

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Thyroid Function Abnormalities among Hospital Patients of Hilly Nepal

Dangol¹,

Lanjekar²,

Pulipati³

2017

J Lumbini Med Coll

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Introduction: Thyroid dysfunction stands as the second most common endocrine disease after diabetes mellitus. National reports on its prevalence are meagre. Hence, the study was conducted with the objective of exploring the prevalence of thyroid dysfunction among hospital patients of hilly region of Nepal. Methods: A hospital based, retrospective, analytical study was conducted in the department of biochemistry, Lumbini Medical College Teaching Hospital (LMCTH) from 15th February 2017 to 30th April 2017. The hospital records of patients from March 2014 to mid-February 2017 with suspected thyroid dysfunction and presented from different departments of hospital were reviewed. Data was entered in Excel 2007 and analysis was done with Statistical Package for Social Sciences (SPSS-21). Necessary descriptive and inferential statistical analysis was done. P value less than 0.05 was regarded as statistically significant. Results: Out of 3136 subjects, 601 (19.2%) were male and 2535 (80.8%) were female with F:M ratio of 4.2:1. Female were more likely to be suspected of thyroid dysfunction. Mean age of male was 39.28 years (SD = 19.01) and that of female was 39.60 years (SD = 14.63). Prevalence of thyroid dysfunction was 23.31%. Correlation of log10 TSH with age showed a significant relation (r = -0.05, p = 0.003). Age group and thyroid function category among female patients was found to be statistically significant (p = 0.01). Conclusion: The prevalence of thyroid dysfunction was high in Tansen region, a hilly mid-west Nepal. Female above 40 yrs (post reproductive age) and male above 60 yrs (elderly group) were more prone to thyroid disorders. Also, the study revealed that younger people are more likely to be euthyroid whereas as age advances, people are likely to be either hypothyroid or hyperthyroid. These findings can be a guide for elaborative research in thyroid disorder in future.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Thyroid Function Abnormalities among Hospital Patients of Hilly Nepal

Dangol¹,

Lanjekar²,

Pulipati³

2017

J Lumbini Med Coll

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“…Thyroid dysfunction is a common endocrine disorder affecting around 300 million people worldwide and it is presumed that more than half are unaware of their condition. The major thyroid disorders are hyperthyroidism and hypothyroidism, with 1.6 billion people at risk in more than 110 countries around the world [10]. The prevalence of hypothyroidism in the US population was 4.6%, but there is a clinically evident hypothyroidism in 0.3%.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Dysfunction and Cytological Patterns among Patients Requested for Thyroid Function Test in an Endemic Goiter Area of Gondar, North West Ethiopia

Asmelash

Tesfa

2019

International Journal of Endocrinology

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Background. Thyroid dysfunction is the most common endocrine disorder in clinical practice, and about half of the population with thyroid dysfunction remains undiagnosed. There is a fairly wide spectrum of thyroid dysfunction, which can be identified by patterns of thyroid function test results. The prevalence of thyroid dysfunction among the population varies in different studies. Methods. A cross-sectional study was conducted from February 8th to April 8th, 2017, among patients who requested for the thyroid function test in an endemic goiter area at the Gondar Hospital, University of Gondar. A pretested structured questionnaire was used to collect the data. Three milliliters of blood samples was collected in a plain test tube and centrifuged for serum separation. The thyroid function test was done by using the MINI-VIDAS automation following the manufacturer manual (Setema PLC, Italy). Data were entered and analyzed using SPSS version 20. Descriptive statistics were used for data presentation, and P value < 0.05 was considered significant. Result. Of the total 384 study participants, 346 (90.1%) were females and the study participants’ mean age was 38 ± 13.9 years. The overall thyroid dysfunction prevalence was 26.3% (101): 1.6% was identified as subclinical hypothyroidism, 0.5% hypothyroidism, 9.6% subclinical hyperthyroidism, and 14.6% hyperthyroidism, and 23.4% had goiter. Furthermore, for cytological pattern analysis, 144 study participants who fulfilled indications for fine-needle aspiration cytology (FNAC) in thyroid nodules were included. Of the total, 3 (2.1%) had thyroid carcinoma, 46 (32%) had cystic degenerated follicular cells, and 82 (57%) had nodular thyroid goiter. In addition, a clinical presentation of a total of 144 study participants, showed lymphadenites in 7 participants (4.8%), hypertension in 9 (6.2%), and cardiac failure in 12 (8.3%). Conclusion. The prevalence of thyroid dysfunction was high. The majority of thyroid dysfunction cases were newly diagnosed and more common in females. In addition, the most common disorders were subclinical hyperthyroidism and hyperthyroidism. Follicular cell with cyst degeneration and thyroid nodular goiter were the predominant FNAC findings. For early diagnosis and appropriate intervention in goiter endemic areas, the thyroid function test should be closely monitored.

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“…1 Thyroid dysfunction generally manifests in the form of either hyperthyroidism or hypothyroidism due to over or under-secretion of thyroid hormone, respectively. 2 This is also associated with abnormalities of thyroid function tests (TFTs), such as thyrotropin (TSH) and thyroid hormones, (free triiodothyronine,fT3 and free thyoxine,fT4). 1 Hyperthyroidism is a pathological condition which is characterized by excess of thyroid hormone in the circulation and is more common in women.…”

Section: Introductionmentioning

confidence: 99%

Hyperthyroidism; Prevalence in Abbottabad, Pakistan: A Hospital Based Study

Anjum

Durrani

Hussain

et al. 2016

TPMJ

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Thyroid disorders are one of the common endocrine disorders. Their prevalence is affected by many factors, especially environmental and nutritional ones. Objectives: To ascertain the seroprevalence of hyperthyroidism in clinically suspected hyperthyroid patients. Design: Descriptive cross-sectional study. Setting: Frontier Medical & Dental College, Abbottabad. Period: January to August, 2015. Methods: One hundred and twenty patients were included in the study based on inclusion and exclusion criteria. Thyroid function tests (TSH, fT3 & fT4) were performed using enzyme linked immunoassay (ELISA) method. Results: There was preponderance of males in our study with male to female ratio of 1.4:1. Maximum patients (56.67 %) were between the ages of 21-40 years of age, with mean age of study population to be 32.09±13.01 years. The prevalence of hyperthyroidism was 15% based on the results of thyroid function tests. There were 11 males and 7 females with male to female ratio of 1.57:1 and mean age of hyperthyroid patients was 25.72± 8.27 years. The mean value of TSH, fT3 and fT4 was 0.038±0.025 mIU/L, 7.08±2.19 ng/mL and 25.25±6.30 µg/dL respectively in hyperthyroid patients as compared to 3.15±2.23 mIU/L, 2.05±0.88 ng/mL and 10.69±2.69 µg/dL in euthyroid subjects. Conclusion: Thyroid disorders are not very rare among general population. TFTs provide a reliable way of ascertaining the thyroid function. As this is a hospital based study, field studies should be conducted to ascertain the true prevalence of thyroid disorders in the community.

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Socio demographic wise risk assessment of thyroid function abnormalities in far western region of Nepal: A hospital based descriptive study

Cited by 14 publications

References 21 publications

Thyroid Function Abnormalities among Hospital Patients of Hilly Nepal

Thyroid Function Abnormalities among Hospital Patients of Hilly Nepal

Thyroid Dysfunction and Cytological Patterns among Patients Requested for Thyroid Function Test in an Endemic Goiter Area of Gondar, North West Ethiopia

Hyperthyroidism; Prevalence in Abbottabad, Pakistan: A Hospital Based Study

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