Socially induced plasticity in sensorimotor gating in the African cichlid fish Astatotilapia burtoni

Neumeister, Heike; Adelman, Mila; Gallagher, William F.; Gou, Jiangtao; Merrins, Karin; Perkowski, Melissa; Shih, Stephanie; Terranova, Beth; Preuss, Thomas

doi:10.1016/j.bbr.2017.05.049

Cited by 4 publications

(4 citation statements)

References 82 publications

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“…C-start reflexes involved in response to sudden threats are controlled by a pair of large reticulospinal neurons, the M-cells, and their associated excitatory and inhibitory networks. The M-cells elicit a fast (around 10 ms) muscle reflex contraction, enabling the body to bend away from the direction of a predator attack in a "C-shape" fashion (29,49). We hypothesized that the reduced response latency of offspring from predator-exposed mothers was caused by an increased excitability of the M-cells.…”

Section: Discussionmentioning

confidence: 99%

Predator-induced maternal effects determine adaptive antipredator behaviors via egg composition

Sharda

Zuest

Erb

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

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In high-risk environments with frequent predator encounters, efficient antipredator behavior is key to survival. Parental effects are a powerful mechanism to prepare offspring for coping with such environments, yet clear evidence for adaptive parental effects on offspring antipredator behaviors is missing. Rapid escape reflexes, or “C-start reflexes,” are a key adaptation in fish and amphibians to escape predator strikes. We hypothesized that mothers living in high-risk environments might induce faster C-start reflexes in offspring by modifying egg composition. Here, we show that offspring of the cichlid fish Neolamprologus pulcher developed faster C-start reflexes and were more risk averse if their parents had been exposed to cues of their most dangerous natural predator during egg production. This effect was mediated by differences in egg composition. Eggs of predator-exposed mothers were heavier with higher net protein content, and the resulting offspring were heavier and had lower igf-1 gene expression than control offspring shortly after hatching. Thus, changes in egg composition can relay multiple putative pathways by which mothers can influence adaptive antipredator behaviors such as faster escape reflexes.

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Section: Discussionmentioning

confidence: 99%

Predator-induced maternal effects determine adaptive antipredator behaviors via egg composition

Sharda

Zuest

Erb

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

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“…In order to have an intact nervous system, the body develops a variety of mechanisms to suppress or "filter out" irrelevant information in the sensory, cognitive and motor domains to allow an individual to focus on the most relevant stimuli of the environment, thus protecting the nervous system against an excess of information (Braff & Geyer, 1990; Weiss & Feldon, 2001). This capacity is compromised in people with some psychiatric disorders (Neumeister et al., 2017; O'Connor & O'Shea, 2015).…”

Section: Discussionmentioning

confidence: 99%

Ascorbic acid supplementation attenuates schizophrenia‐like symptoms in an animal model induced by ketamine

Supp

Avila

Mastella

et al. 2020

Intl J of Devlp Neuroscience

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Schizophrenia is a chronic neuropsychiatric disorder with a poorly understood pathophysiology. The theories about the disorder are mainly about dysregulation in one or more systems of neurotransmitters, and the progression triggers the presence of inflammatory markers indicates the possibility that the disorder is initially an inflammatory disease. The objective was to evaluate the ascorbic acid supplementation in an animal model of schizophrenia, on behavioral parameters, and cytokines involved in inflammation IL‐1β, IL‐10. Wistar rats with 60 days of age were used which were supplemented with ascorbic acid at 0.1, 1, and 10 mg/kg or saline for 14 days via orogastric gavage. Subsequently, four groups were given ketamine (25 mg/kg) and four groups received intraperitoneal saline from the 9th‐15th day of the experiment. After 30 min of the last administration of ketamine/saline, and behavioral test, rats were killed by guillotine decapitation and the brain structures were carefully dissected for biochemical analysis. Results showed that ascorbic acid supplementation prevented motor sensory loss but nor alter other parameters evaluated. We concluded that ascorbic acid may be used as a therapeutic adjuvant in schizophrenia and may help to improve the schizophrenic patient's life quality.

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“…Therefore, M-cell excitability is directly correlated with changes in the startle responsiveness, and are a predictor of behavioral output (Preuss and Faber, 2003 ; Korn and Faber, 2005 ; Neumeister et al, 2008 ; Curtin et al, 2013 ). Accordingly, M-cells have been employed to study startle plasticity and sensorimotor gating in goldfish (Medan and Preuss, 2011 ; Curtin et al, 2013 ) African cichlids (Neumeister et al, 2010 , 2017 ; Whitaker et al, 2011 ) and zebrafish (Burgess and Granato, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

“…M-cell activation depends on massive excitation that is opposed by tonic and feed-forward networks, which include modulation through dopaminergic and serotonergic inputs (Furshpan and Furukawa, 1962 ; Faber and Korn, 1982 ; Pereda et al, 1992 ; Medan and Preuss, 2011 ; Curtin et al, 2013 ). As such, M-cell excitability is sensitive to changes in physiological state and environmental stressors such as predator pressure and social defeat (Neumeister et al, 2010 , 2017 ; Whitaker et al, 2011 ; Fischer et al, 2014 ). Thus, here we asked if cortisol could mediate such changes at the level of the M-cell.…”

Section: Introductionmentioning

confidence: 99%

Cellular Mechanisms of Cortisol-Induced Changes in Mauthner-Cell Excitability in the Startle Circuit of Goldfish

Bronson

Preuss

2017

Front. Neural Circuits

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Predator pressure and olfactory cues (alarm substance) have been shown to modulate Mauthner cell (M-cell) initiated startle escape responses (C-starts) in teleost fish. The regulation of such adaptive responses to potential threats is thought to involve the release of steroid hormones such as cortisol. However, the mechanism by which cortisol may regulate M-cell excitability is not known. Here, we used intrasomatic, in vivo recordings to elucidate the acute effects of cortisol on M-cell membrane properties and sound evoked post-synaptic potentials (PSPs). Cortisol tonically decreased threshold current in the M-cell within 10 min before trending towards baseline excitability over an hour later, which may indicate the involvement of non-genomic mechanisms. Consistently, current ramp injection experiments showed that cortisol increased M-cell input resistance in the depolarizing membrane, i.e., by a voltage-dependent postsynaptic mechanism. Cortisol also increases the magnitude of sound-evoked M-cell PSPs by reducing the efficacy of local feedforward inhibition (FFI). Interestingly, another pre-synaptic inhibitory network mediating prepulse inhibition (PPI) remained unaffected. Together, our results suggest that cortisol rapidly increases M-cell excitability via a post-synaptic effector mechanism, likely a chloride conductance, which, in combination with its dampening effect on FFI, will modulate information processing to reach threshold. Given the central role of the M-cell in initiating startle, these results are consistent with a role of cortisol in mediating the expression of a vital behavior.

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Socially induced plasticity in sensorimotor gating in the African cichlid fish Astatotilapia burtoni

Cited by 4 publications

References 82 publications

Predator-induced maternal effects determine adaptive antipredator behaviors via egg composition

Predator-induced maternal effects determine adaptive antipredator behaviors via egg composition

Ascorbic acid supplementation attenuates schizophrenia‐like symptoms in an animal model induced by ketamine

Cellular Mechanisms of Cortisol-Induced Changes in Mauthner-Cell Excitability in the Startle Circuit of Goldfish

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