Social vs. environmental stress models of depression from a behavioural and neurochemical approach

Venzala, E.; Garcia-García, Álvaro L.; Elizalde, N.; Tordera, Rosa M.

doi:10.1016/j.euroneuro.2012.05.010

Cited by 98 publications

(86 citation statements)

References 81 publications

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“…In addition, it might also promote maladaptive behavioral responses to subsequent stresses (Elizalde et al, 2010). For instance, our CSDS model induces long-lasting neurochemical alterations in this region (Venzala et al, 2013) that have been associated to anhedonia (Banasr et al, 2010). In agreement with this idea, anhedonia has been shown to correlate with a dysfunction of the prefrontal cortex in depressed patients (Germine et al, 2011;Keedwell et al, 2005).…”

Section: Introductionmentioning

confidence: 53%

“…Our laboratory and others have evaluated the long term effects of CSDS in different behavioral tests (Becker et al, 2008;Venzala et al, 2012). Specifically, up to four-five weeks after the cessation of the social defeat procedure, we have observed anhedonia, a core symptom of clinical depression, i.e., loss of interest in normally rewarding stimuli, but also anxiety and social avoidance, signs also related to anxiety and posttraumatic stress disorders (Venzala et al, 2012(Venzala et al, , 2013. Interestingly, anhedonia and some of these behaviors induced by CSDS have been effectively reversed or prevented by different monoaminergic antidepressants supporting the predictive validity of this model (Venzala et al, 2012).…”

Section: Introductionmentioning

confidence: 98%

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Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity

Erburu

Muñoz-Cobo

Domínguez‐Andrés

et al. 2015

European Neuropsychopharmacology

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Section: Introductionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 98%

Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity

Erburu

Muñoz-Cobo

Domínguez‐Andrés

et al. 2015

European Neuropsychopharmacology

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“…For example, Valenti found that chronic mild stress inhibited, while chronic social stress increased, the activity of dopaminergic neurons in the VTA (Valenti et al.,2012). Venzala's study demonstrated that chronic mild stress and social stress exerted inconsistent effects on various neurotransmitters' levels in many brain regions (Venzala et al.,2013). In this study, MD and CUPS induce dissimilar alterations in rats' mesocorticolimbic dopaminergic system.…”

Section: Discussionmentioning

confidence: 99%

“…Results from recent studies indicated that different types of chronic stress might exert different effects on the sufferers' central nervous system (Valenti, Gill, & Grace,2012; Venzala, Tordera, García‐ García, & Elizalde,2013). For example, Valenti found that chronic mild stress inhibited, while chronic social stress increased, the activity of dopaminergic neurons in the VTA (Valenti et al.,2012).…”

Section: Discussionmentioning

confidence: 99%

Divergent anomaly in mesocorticolimbic dopaminergic circuits might be associated with different depressive behaviors, an animal study

et al. 2017

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BackgroundThe mesocorticolimbic dopamine system, which originates from the ventral tegmental area (VTA) and projects primarily to the prefrontal cortex (PFC), olfactory tubercle (OT), nucleus accumbens (NAc), dorsal striatum (ST), and the amygdala (AMy), plays a pivotal role in determining individual motivation and sensitivity to rewards, namely, anhedonia. Not all depressive individuals exhibited anhedonia, thus, it is natural to speculate that the heterogenous manifestations of depression might be related to the mesocorticolimbic dopamine system. Maternal deprivation (MD) and chronic unpredictable stress (CUPS) are two well‐established depressogenic stressors, and they were proven to induce different depressive phenotypes.MethodsThe depressive and anxiety‐like behaviors of MD and CUPS‐treated rats were measured by classical behavioral tests including open field, forced swimming, and sucrose preference test. The expression of D1‐5 dopamine receptors and DAT mRNA and protein in the mesocorticolimbic dopamine system of rats exposed to MD and CUPS were measured by real‐time PCR and Western blot, respectively.ResultsSevere anhedonia was observed in MD but not CUPS rats. Divergent expression of D1 and D2 receptors and DAT mRNA and protein in the mesocorticolimbic dopamine system were found between MD and CUPS rats. Significant correlations between different depressive behaviors and D1‐/D2‐like receptors and DAT protein levels in the mesocorticolimbic dopamine system were observed.ConclusionDifferent depressive behaviors of rats such as anhedonia, passive coping behavior, and declined exploratory interest might be related to divergent dopaminergic pathways. Anhedonia is associated with the dysfunction of VTA‐NAc and VTA‐OT dopaminergic pathways, the passive coping behavior is related to the dysregulation of VTA‐PFC and VTA‐AMy pathways, and individual exploratory interest is associated with abnormal activity of VTA‐PFC and VTA‐ST pathways.

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“…the natural need for social interaction and the simultaneous and opposite natural drive to avoid their sick partner. Studies on conflict behavior show that mice are good models for the study of anxiety and psychological stress [23]. If this is the case, then long-term cohabitation with Ehrlich tumor-bearing mice might be thought of as being able to induce psychological stress.…”

Section: Discussionmentioning

confidence: 99%

Odor Cues Released by Ehrlich Tumor-Bearing Mice Are Aversive and Induce Psychological Stress

Alves¹,

Palermo-Neto²

2014

Neuroimmunomodulation

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Background/Aims: This study aimed to verify if odor cues released by Ehrlich tumor-bearing mice are aversive and stressful. Methods: Female mice were divided into a control group and an experimental group. One animal of each experimental pair of mice was inoculated with 5 × 10⁶ Ehrlich tumor cells intraperitoneally; the other animal was kept undisturbed and was referred to as a CSP (companion of sick partner). One mouse of each control pair was treated intraperitoneally with 0.9% NaCl (1 mg/kg); the other animal (CHP, companion of healthy partner) was kept undisturbed. Results: It was shown that, in relation to CHP, CSP mice (1) spent less time within the companion zone in a T-maze place preference test, (2) had increased levels of social interaction, (3) had increased levels of plasmatic adrenaline and noradrenaline and (4) displayed no changes in serum corticosterone levels before and after an immobilization stress challenge. It was also shown that (5) cohabitation with 2 tumor-bearing mice was more effective in decreasing neutrophil oxidative burst than cohabitation with 1 sick partner and (6) the presence of a healthy conspecific within the cage of the tumor-injected/CSP pair abrogated the effects of cohabitation on neutrophil activity. These results show that odor cues released by Ehrlich tumor-injected mice are aversive and induce psychological stress. Conclusion: We postulate that the aversive response induced by the chemosignals released by Ehrlich tumor-injected animals activates the sympathetic nervous system and causes the neuroimmunal changes that occur in the mice cohabiting with the sick mice.

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Social vs. environmental stress models of depression from a behavioural and neurochemical approach

Cited by 98 publications

References 81 publications

Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity

Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity

Divergent anomaly in mesocorticolimbic dopaminergic circuits might be associated with different depressive behaviors, an animal study

Odor Cues Released by Ehrlich Tumor-Bearing Mice Are Aversive and Induce Psychological Stress

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