Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity

Erburu, M.M.; Muñoz-Cobo, I.; Domínguez‐Andrés, Jorge; Beltrán, Elena; Suzuki, Takayoshi; Mai, Antonello; Valente, Sérgio; Puerta, Elena; Tordera, Rosa M.

doi:10.1016/j.euroneuro.2015.08.016

Cited by 52 publications

(33 citation statements)

References 54 publications

(60 reference statements)

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“…In the present study, sodium butyrate increases the AK-7-induced reduction of novel object recognition memory, cell proliferation, and neuroblast differentiation. This result is supported by previous studies indicating that sodium butyrate ameliorates memory impairment caused by hippocampus-related diseases such as cerebral hypoperfusion, autism, and chronic mild stress [193946]. In addition, we demonstrated that sodium butyrate significantly increases cell proliferation and neuroblast differentiation in normal mice [23] and mice with brain ischemia [22].…”

Section: Discussionsupporting

confidence: 90%

“…This result is supported by Liu et al [38] who showed that SIRT2 inhibition by tenovin-D3 causes depression-like behavior and reduces the number of 5-bromo-2'-deoxyuridine (BrdU)-positive cells in the dentate gyrus of rats, while overexpression of SIRT2 by adenovirus significantly increases the BrdU-positive cells in the rat dentate gyrus [38]. Three-week long repeated treatment with MC1568, a histone deacetylase inhibitor, and 33i, a SIRT2 inhibitor, increased synaptic plasticity in the prefrontal cortex [39]. …”

Section: Discussionmentioning

confidence: 99%

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Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation

et al. 2016

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We investigated the effects of the sirtuin-2 (SIRT2) inhibitor AK-7 on novel object memory, cell proliferation, and neuroblast differentiation in the dentate gyrus. In addition, we also observed the relationships with sodium butyrate, a histone deacetylase inhibitor, on the hippocampal functions. To investigate the effects of AK-7 on hippocampal functions, 10-week-old C57BL/6 mice were daily injected intraperitoneally with 20 mg/kg AK-7 alone or in combination with subcutaneous administration of 300 mg/kg sodium butyrate, a histone deacetylase inhibitor, for 21 days. A novel object recognition test was conducted on days 20 (training) and 21 (testing) of treatment. Thereafter, the animals were sacrificed for immunohistochemistry for Ki67 (cell proliferation) and doublecortin (DCX, neuroblast differentiation). AK-7 administration significantly reduced the time spent exploring new objects, while treatment in combination with sodium butyrate significantly alleviated this reduction. Additionally, AK-7 administration significantly reduced the number of Ki67-positive cells and DCX-immunoreactive neuroblasts in the dentate gyrus, while the treatment in combination with sodium butyrate ameliorated these changes. This result suggests that the reduction of SIRT2 may be closely related to age-related phenotypes including novel object memory, as well as cell proliferation and neuroblast differentiation in the dentate gyrus. In addition, sodium butyrate reverses SIRT2-related age phenotypes.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation

et al. 2016

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“…The patterns of histone H3 acetylation in the BDNF exon I promoter on MS and ESC rats may be regulated by histone deacetylase (HDAC) expression. Specifically, rodent and human studies have found that HDAC5 is regulated by stress and antidepressant drugs . In a previous study, we investigated the effect of MS and ESC treatment on expression of HDAC5 in the hippocampus .…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, rodent and human studies have found that HDAC5 is regulated by stress and antidepressant drugs. 49,[53][54][55] In a previous study, we investigated the effect of MS and ESC treatment on expression of HDAC5 in the hippocampus. 33 Hippocampal mRNA levels of HDAC5 were upregulated in MS rats, and this effect was prevented by chronic ESC.…”

Section: Discussionmentioning

confidence: 99%

Effects of maternal separation and antidepressant drug on epigenetic regulation of the brain‐derived neurotrophic factor exon I promoter in the adult rat hippocampus

Park

Seo

Lee

et al. 2017

Psychiatry Clin Neurosci

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“…Therefore, the two brain structures, nucleus accumbens and hippocampus, seem to play a different role in depression-related behavior, probably via HDAC 5 functions that need to be further investigated. Otherwise, recent studies suggest a role for SIRT2 in depression in different models, by regulating hippocampal neurogenesis in a rat chronic unpredictable stress model (97), and by an upregulation in conjunction with HDAC 5 in the prefrontal cortex upon the chronic social defeat stress model (98).…”

Section: Stressmentioning

confidence: 99%

Histone acetylation in neuronal (dys)function

Bonnaud¹,

Suberbielle²,

Malnou³

2016

Biomolecular Concepts

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Abstract:Cognitive functions require the expression of an appropriate pattern of genes in response to environmental stimuli. Over the last years, many studies have accumulated knowledge towards the understanding of molecular mechanisms that regulate neuronal gene expression. Epigenetic modifications have been shown to play an important role in numerous neuronal functions, from synaptic plasticity to learning and memory. In particular, histone acetylation is a central player in these processes. In this review, we present the molecular mechanisms of histone acetylation and summarize the data underlying the relevance of histone acetylation in cognitive functions in normal and pathological conditions. In the last part, we discuss the different mechanisms underlying the dysregulation of histone acetylation associated with neurological disorders, with a particular focus on environmental causes (stress, drugs, or infectious agents) that are linked to impaired histone acetylation.

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Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity

Cited by 52 publications

References 54 publications

Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation

Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation

Effects of maternal separation and antidepressant drug on epigenetic regulation of the brain‐derived neurotrophic factor exon I promoter in the adult rat hippocampus

Histone acetylation in neuronal (dys)function

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