Social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment

Bai, Hongliang; Capitanio, John P.; Miller, Lisa; Clougherty, Jane E.

doi:10.1016/j.heliyon.2021.e08333

Cited by 2 publications

(3 citation statements)

References 76 publications

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“…Previous studies of PM exposures suggest specific respiratory conditions that could result from wildfire smoke exposure, and may or may not require prescriptions treatment. For example, developmental exposures to PM or biomass burning are associated with early life deficits in lung function [48][49][50], and increased susceptibility to acute respiratory infection (ARI) or infant bronchiolitis [51,52]. While ARI is often treated with prescription medication in young children, subclinical deficits in lung function associated with developmental air pollution exposure may not always be identified and treated with prescription medication unless they lead to respiratory infection [23,50,[53][54][55][56][57][58].…”

Section: Discussionmentioning

confidence: 99%

Wildfire smoke exposure and early childhood respiratory health: a study of prescription claims data

et al. 2023

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Wildfire smoke is associated with short-term respiratory outcomes including asthma exacerbation in children. As investigations into developmental wildfire smoke exposure on children’s longer-term respiratory health are sparse, we investigated associations between developmental wildfire smoke exposure and first use of respiratory medications. Prescription claims from IBM MarketScan Commercial Claims and Encounters database were linked with wildfire smoke plume data from NASA satellites based on Metropolitan Statistical Area (MSA). A retrospective cohort of live infants (2010–2016) born into MSAs in six western states (U.S.A.), having prescription insurance, and whose birthdate was estimable from claims data was constructed (N = 184,703); of these, gestational age was estimated for 113,154 infants. The residential MSA, gestational age, and birthdate were used to estimate average weekly smoke exposure days (smoke-day) for each developmental period: three trimesters, and two sequential 12-week periods post-birth. Medications treating respiratory tract inflammation were classified using active ingredient and mode of administration into three categories:: 'upper respiratory', 'lower respiratory', 'systemic anti-inflammatory'. To evaluate associations between wildfire smoke exposure and medication usage, Cox models associating smoke-days with first observed prescription of each medication category were adjusted for infant sex, birth-season, and birthyear with a random intercept for MSA. Smoke exposure during postnatal periods was associated with earlier first use of upper respiratory medications (1–12 weeks: hazard ratio (HR) = 1.094 per 1-day increase in average weekly smoke-day, 95%CI: (1.005,1.191); 13–24 weeks: HR = 1.108, 95%CI: (1.016,1.209)). Protective associations were observed during gestational windows for both lower respiratory and systemic anti-inflammatory medications; it is possible that these associations may be a consequence of live-birth bias. These findings suggest wildfire smoke exposure during early postnatal developmental periods impact subsequent early life respiratory health.

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Section: Discussionmentioning

confidence: 99%

Wildfire smoke exposure and early childhood respiratory health: a study of prescription claims data

et al. 2023

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“…Previous studies of PM exposures suggest specific respiratory conditions that could result from wildfire smoke exposure, and may or may not require prescriptions treatment. For example, developmental exposures to PM or biomass burning are associated with early life deficits in lung function [41][42][43] , and increased susceptibility to acute respiratory infection (ARI) or infant bronchiolitis 44,45 . While ARI is often treated with prescription medication in young children, subclinical deficits in lung function associated with developmental air pollution exposure may not always be identified and treated with prescription medication unless they lead to respiratory infection 21,43,[46][47][48][49][50][51] .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Wildfire smoke exposure and early childhood respiratory health: a study of prescription claims data

Dhingra

Keeler

Staley

et al. 2022

Preprint

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Wildfire smoke is associated with short-term respiratory outcomes including asthma exacerbation in children. As investigations into developmental wildfire smoke exposure (WSE) on children's longer-term respiratory health are sparse, we investigated associations between developmental WSE and first use of respiratory medications. Prescription claims from IBM MarketScan Commercial Claims and Encounters database were linked with wildfire smoke plume data from NASA satellites based on Metropolitan Statistical Area (MSA). A retrospective cohort of live infants (2010-2016) born into MSAs in six western states, having prescription insurance, and whose birthdate was estimable from claims data was constructed (N=184,703); of these, gestational age was estimated for 113,154 infants. MSA, gestational age, and birthdate were used to estimate average weekly smoke exposure days (smoke-day) for each developmental period: three trimesters, and two sequential 12-week periods post-birth. Medications treating respiratory tract inflammation were classified using active ingredient and mode of administration into three categories: upper respiratory, lower respiratory, systemic anti-inflammatory. To evaluate associations between WSE and medication usage, Cox models associating smoke-days with first observed prescription of each medication category were adjusted for infant sex, birth-season, and birthyear with a random intercept for MSA. Smoke exposure during postnatal periods was associated with earlier first use of upper respiratory medications (1-12 weeks: hazard ratio (HR)=1.094 per 1-day increase in average weekly smoke-day, 95%CI: (1.005,1.191); 13-24 weeks: HR=1.108, 95%CI: (1.016,1.209)); sex-specific HRs varied by post-birth exposure window. Protective associations were observed during gestational windows for both lower respiratory and systemic anti-inflammatory medications; it is possible that these associations may be a consequence of live-birth bias. These findings suggest WSE during early postnatal developmental periods impact subsequent early life respiratory health.

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Social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment

Cited by 2 publications

References 76 publications

Wildfire smoke exposure and early childhood respiratory health: a study of prescription claims data

Wildfire smoke exposure and early childhood respiratory health: a study of prescription claims data

Wildfire smoke exposure and early childhood respiratory health: a study of prescription claims data

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