Social functioning, theory of mind and neurocognition in outpatients with schizophrenia; mental state decoding may be a better predictor of social functioning than mental state reasoning

Bora, Emre; Eryavuz, Ayse; Kayahan, Bülent; Sungu, Gulcin; Veznedaroğlu, Baybars

doi:10.1016/j.psychres.2005.11.003

Cited by 252 publications

(158 citation statements)

References 47 publications

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“…One study reported in 2 papers indicated an opposite significant relationship between the variables (Bland & Parker, 1978; Bland et al, 1976). Stronger ( r ≥ 0.30) correlations were also reported (Boato, Caputo, Comazzi, & Ferrari, 1995; Bora, Eryavuz, Kayahan, Sungu, & Veznedaroglu, 2006; Greig, Bell, Kaplan, & Bryson, 2000). In meta‐analysis, a lower age at onset predicted poorer social/occupational functioning (n = 12; r = 0.15; 95% CI 0.05–0.25; P = .002).…”

Section: Resultsmentioning

confidence: 80%

Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis

Immonen

Jääskeläinen

Korpela

et al. 2017

Early Intervention Psych

216

116

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The aim of this study was to analyse the effect of age at onset on the long‐term clinical, social and global outcomes of schizophrenia through a systematic review and a meta‐analysis. Original studies were searched from Web of Science, PsycINFO, Pubmed and Scopus, as well as manually. Naturalistic studies with at least a 2‐year follow‐up were included. Of the 3509 search results, 81 articles fulfilled the inclusion criteria. The meta‐analysis was performed in Stata as a random‐effect analysis with correlation coefficients between age at onset and the outcomes (categorized into remission, relapse, hospitalization, positive symptoms, negative symptoms, total symptoms, general clinical outcome, employment, social/occupational functioning and global outcome). There was a statistically significant (P < .05) correlation between younger age at onset and more hospitalizations (number of studies, n = 9; correlation, r = 0.17; 95% confidence interval, CI 0.09–0.25), more negative symptoms (n = 7; r = 0.14; 95% CI 0.01–0.27), more relapses (n = 3; r = 0.11; 95% CI 0.02–0.20), poorer social/occupational functioning (n = 12; r = 0.15; 95% CI 0.05–0.25) and poorer global outcome (n = 13; r = 0.14; 95% CI 0.07–0.22). Other relationships were not significant. This was the first systematic review of the effects of age at onset on the long‐term outcomes of schizophrenia. The results show that age at onset has a small, but significant impact on some of the outcomes of schizophrenia.

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Section: Resultsmentioning

confidence: 80%

Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis

Immonen

Jääskeläinen

Korpela

et al. 2017

Early Intervention Psych

216

116

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“…Studies conducted in recent years demonstrated strong evidence that OT has a role in the etiology of mental disorders leading to difficulties in social communication [49]. In a recent study, a negative correlation between the severity of the symptoms of SCH and basal OT levels is shown [50].…”

Section: Discussionmentioning

confidence: 95%

Oxytocin and social cognition in patients with schizophrenia: comparison with healthy siblings and healthy controls

Balıkçı

Aydın

Taş

et al. 2017

Psychiatry and Clinical Psychopharmacology

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Objective: There is substantial evidence from animal research indicating a key role of the neuropeptide oxytocin (OT) in the regulation of complex social cognition and behaviour. Social cognition is indispensable for social relationships for the whole of human society, and numerous studies have shown impaired social cognition in schizophrenia (SCH) and unaffected first-degree relatives also seem to be impaired, albeit to a lesser extent. Because of that, this study focuses on the role of OT in social cognition in SCH. Methods: Twenty-seven patients with SCH, 27 healthy siblings (HS) of these patients, and 27 psychologically healthy controls (HC) were included in the study. Blood samples were collected through a peripheral venous catheter. Differences in the socio-demographical and WAIS-R were tested by chi-square and one way-ANOVA. To explore the relationships between social cognition and blood samples we performed Pearson correlations. MANCOVA (gender and WAIS-R as covariates) test was performed to investigate the effect of gender on blood levels of OT and WAIS-R on social cognition. Results: Significant differences were found in neurocognitive and social cognitive capacity but not in OT levels. In the healthy control group, there was a positive correlation between blood OT levels and RMET. There is a statistically significant difference between high and low OT groups with regard to social cognition in all subtests of the RMET. Conclusions: In the current study, we found that patients had deficits in social cognition and neurocognition. Lower endogenous OT levels are also predictive for poor social cognitive functioning in HS and HC.ARTICLE HISTORY

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“…This paradigm involves more automatic skills, and it has been called socioperceptual or mental state decoding (Bora, Eryavuz, Kayahan, Sungu, & Veznedaroglu, 2006;Gokcen, Bora, Erermis, Kesikci, & Aydin, 2009;Sabbagh et al, 2004). In the Face Test (Adolphs, 2002), the participant is asked to look at a picture of a face and name which of seven basic emotions it represents (i.e., happiness, fear, surprise, disgust, sadness, anger, and distress).…”

Section: Assessment Of Theory Of Mindmentioning

confidence: 99%

Social cognition and Theory of Mind: Controversies and promises for understanding major psychiatric disorders.

Martins-Junior

Sanvicente‐Vieira

Grassi‐Oliveira

et al. 2011

Psychology & Neuroscience

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The term "social cognition" generally refers to the mental operations that underlie social interactions including the perception and interpretation of the intentions, dispositions, and behaviors of others and the generation of a response to these behaviors. Social cognition has been considered a valuable and promising field that strives to understand the nature and outcome of major mental disorders. This article discusses the concept of social cognition and its relationship to Theory of Mind (ToM). Theory of Mind in autistic spectrum disorders has been studied since the 1980s, and cognitive impairments in these disorders may be restricted to ToM deficits because other cognitive domains and nonsocial intelligence are preserved. This article addresses the issues of human ontogeny, reviews the main findings from research on schizophrenia and bipolar disorder, and summarizes the tools commonly used in the assessment of these illnesses.

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Social functioning, theory of mind and neurocognition in outpatients with schizophrenia; mental state decoding may be a better predictor of social functioning than mental state reasoning

Cited by 252 publications

References 47 publications

Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis

Age at onset and the outcomes of schizophrenia: A systematic review and meta‐analysis

Oxytocin and social cognition in patients with schizophrenia: comparison with healthy siblings and healthy controls

Social cognition and Theory of Mind: Controversies and promises for understanding major psychiatric disorders.

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