Social effects of oxytocin in humans: context and person matter

Bartz, Jennifer A.; Zaki, Jamil; Bolger, Niall; Ochsner, Kevin N.

doi:10.1016/j.tics.2011.05.002

Cited by 979 publications

(1,428 citation statements)

References 99 publications

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“…Therefore it is reasonable to assume that markedly different dog breeds (such as Border Collies and Siberian Huskies) Our results (together with the findings of Kis et al, 2014a) suggest that we should be cautious in concluding that oxytocin uniformly facilitate social behaviors in dogs. Similar claims have been made in the human literature (Bartz et al, 2011), however many researchers still report their findings as generalizable to a wider population.…”

Section: Discussionsupporting

confidence: 71%

“…The effects of oxytocin are indeed constrained not only by features of situations but also by those of individuals (Bartz et al, 2011). In line with these findings, recent research has shown that behavioral responses to intranasal oxytocin treatment can be linked to oxytocin receptor (OXTR) genotype in humans (Feng et al, 2015;Marsh et al, 2012).…”

Section: Introductionmentioning

confidence: 77%

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Differential effects of oxytocin on social sensitivity in two distinct breeds of dogs ( Canis familiaris )

Kovács

Kis

Pogány

et al. 2016

Psychoneuroendocrinology

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Please cite this article as: {http://dx.doi.org/This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Effects of oxytocin on social sensitivity in two breeds of dogs Kovács et al. HighlightsBreed-specific effects of oxytocin on dogs' social responsiveness were found Genetic and epigenetic factors might contribute to differential oxytocin effects Border Collies are more human oriented than Siberian Huskies Oxytocin affects some social behaviors irrespective of breed Sex differences can be found in the effect of oxytocin on dogs Effects of oxytocin on social sensitivity in two breeds of dogs Kovács et al. 3 ABSTRACTDogs have been proven to show several human-analogue social behaviors, and recent research raises the possibility that the oxytocin system is related to these. However, despite dogs' general tendency to excel in the domain of social cognition, there is increasing evidence that dogs' ability to utilize human signals may vary with breed. Moreover, breeds may show differences not only in their ‗inborn' communicative abilities, but also in their learning skills related to these. The aim of the present study was to explore breed differences and breedspecific effects of oxytocin administration on different aspects of social responsiveness. Dogs from two markedly different breeds, Border Collies (cooperative workers) and Siberian Huskies (independent workers) were tested. After having received intranasal administration of oxytocin or placebo, subjects participated in three behavioral tests measuring social responsiveness. Our results show that there are several behavioral differences between the two breeds and also that there are differential effects of the oxytocin treatment. Border Collies were in general more susceptible to the ‗social' effects of oxytocin compared to Siberian Huskies: after oxytocin administration they (1) looked more at the experimenter in the ‗Unreachable food' situation, (2) looked more at the owner and shifted their gaze more between the sound source and the owner in a potentially dangerous situation, and (3) looked longer at the experimenter's eyes in the ‗Tolerance of prolonged eye contact' test. These findings suggest that selection for enhanced cooperative abilities, possibly complemented by the effect of different social environments the two breeds experience, affects dogs' performance in several behavioral tests and that the neurohormonal background differently modulates social behavior in different working breeds. KeywordsEffects of oxytocin on social sensitivity in two breeds of dogs Kovács et al. 4Oxytocin; Dog (Canis familiaris); Breed differences; Social responsiveness E...

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 77%

Differential effects of oxytocin on social sensitivity in two distinct breeds of dogs ( Canis familiaris )

Kovács

Kis

Pogány

et al. 2016

Psychoneuroendocrinology

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“…However, the effects of OT administration on social perception (and many other outcomes) are often highly context dependent (for review see Bartz et al, 2011;Van IJzendoorn and Bakermans-Kranenburg, 2012). Indeed, OT administration has been shown to have greater benefits for social cognition for individuals lower in social-emotional functioning and has generally been observed in male or clinical samples (e.g., Bartz et al, 2010a;Guastella et al, 2010), which may contribute to the lack of associations with the current gender-diverse and healthy sample.…”

Section: Discussionmentioning

confidence: 99%

“…This is likely in part because the statistical power of OT administration studies tends to be very low and there are likely publication and reporting biases within the field (Lane et al, 2016;Walum et al, 2016), but may also be in part because the effects of OT administration may be highly context-dependent (Bartz et al, 2011;Bakermans-Kranenburg and Van IJzendoorn, 2013;Guastella and MacLeod, 2012;Van IJzendoorn and Bakermans-Kranenburg, 2012). For example, OT administration has been shown to selectively improve the accuracy of social perception for men who are less socially proficient (Bartz et al, 2010a) and on more difficult social perception items (Domes et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Combining oxytocin administration and positive emotion inductions: Examining social perception and analytical performance

Human

Thorson

Woolley

et al. 2017

Hormones and Behavior

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a b s t r a c t a r t i c l e i n f oIntranasal administration of the hypothalamic neuropeptide oxytocin (OT) has, in some studies, been associated with positive effects on social perception and cognition. Similarly, positive emotion inductions can improve a range of perceptual and performance-based behaviors. In this exploratory study, we examined how OT administration and positive emotion inductions interact in their associations with social and analytical performance. Participants (N = 124) were randomly assigned to receive an intranasal spray of OT (40 IU) or placebo and then viewed one of three videos designed to engender one of the following emotion states: social warmth, pride, or an affectively neutral state. Following the emotion induction, participants completed social perception and analytical tasks. There were no significant main effects of OT condition on social perception tasks, failing to replicate prior research, or on analytical performance. Further, OT condition and positive emotion inductions did not interact with each other in their associations with social perception performance. However, OT condition and positive emotion manipulations did significantly interact in their associations with analytical performance. Specifically, combining positive emotion inductions with OT administration was associated with worse analytical performance, with the pride induction no longer benefiting performance and the warmth induction resulting in worse performance. In sum, we found little evidence for main or interactive effects of OT on social perception but preliminary evidence that OT administration may impair analytical performance when paired with positive emotion inductions.

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“…Intranasal OXT has been proposed as a potential therapy to improve social deficits and has few, if any, negative side effects. (Yamasue et al, 2009;Ebstein et al, 2009: Munesue et al, 2010MacDonald et al, 2011;Bartz et al, 2011). In rodents, OXT is highly involved in social interactions, social recognition, pair-bonding, and maternal behavior (Winslow and Insel, 2004;Insel and Fernald, 2004;Young and Wang, 2004;Young, 2007;Neumann, 2008;Donaldson and Young, 2008;Insel, 2010;Higashida et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

CD38 and its role in oxytocin secretion and social behavior

Higashida

Yokoyama

Kikuchi

et al. 2012

Hormones and Behavior

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Here, we review the functional roles of cyclic ADP-ribose and CD38, a transmembrane protein with ADP-ribosyl cyclase activity, in mouse social behavior via the regulation of oxytocin (OXT) release, an essential component of social cognition.Herein we describe data detailing the molecular mechanism of CD38-dependent OXT secretion in CD38 knockout mice. We also review studies that used OXT, OXT receptor (OXTR), or CD38 knockout mice. Additionally, we compare the behavioral impairments that occur in these knockout mice in relation to the OXT system and CD38.This review also examines autism spectrum disorder (ASD), which is characterized by social and communication impairments, in relation to defects in the OXT system. Two single nucleotide polymorphisms (SNPs) in the human CD38 gene are possible risk factors for ASD via inhibition of OXT function. Further analysis of CD38 in relation to the OXT system may provide a better understanding of the neuroendocrinological roles of OXT and CD38 in the hypothalamus and of the pathophysiology of ASD.3

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Social effects of oxytocin in humans: context and person matter

Cited by 979 publications

References 99 publications

Differential effects of oxytocin on social sensitivity in two distinct breeds of dogs ( Canis familiaris )

Differential effects of oxytocin on social sensitivity in two distinct breeds of dogs ( Canis familiaris )

Combining oxytocin administration and positive emotion inductions: Examining social perception and analytical performance

CD38 and its role in oxytocin secretion and social behavior

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