Social decision making in autism: On the impact of mirror neurons, motor control, and imitative behaviors

Khalil, R; Tindle, Richard; Boraud, Thomas; Moustafa, Ahmed A.; Karim, Ahmed A.

doi:10.1111/cns.13001

Cited by 59 publications

(43 citation statements)

References 74 publications

(105 reference statements)

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“…Two brain systems (the mirror and the mentalizing systems) are thought to be involved in the processing of understanding intention (Ciaramidaro et al., 2014). Khalil et al. (2018) suggested a multilayer neural network model including the mirror neuron system (MNS) on a first layer and transforming this information to a higher layer network responsible for reasoning.…”

Section: Discussionmentioning

confidence: 99%

Sophisticated Deception in Junior Middle School Students: An ERP Study

Leng

Wang

et al. 2019

Front. Psychol.

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Sophisticated deception refers to the deception of others based on inferences of their mental states (e.g., answering honestly when inferring that the other will not believe their answer). Studying the brain mechanism of sophisticated deception in junior middle school students can provide physiological evidence for deception detection and deceptive ability measurement. Sixteen junior middle school students were asked to engage in different trial types (i.e., instructed truth/lie and chosen truth/lie), during which we recorded their response times (RT) along with electroencephalographic data to calculate event-related potentials (ERPs). We observed significant differences in amplitude [N2, P3, N450, and medial frontal negativity (MFN)] between chosen reactions (sophisticated deception and simple deception) and instructed reactions (instructed truth and instructed lie) in both the stimulus presentation and feedback stages. In the former, the task scores of participants in the chosen condition were significantly and positively correlated with the N2 amplitude over the central brain area during sophisticated deception. In the latter, the task scores of participants in the chosen condition were negatively correlated with the MFN amplitude over the left frontal and left frontocentral regions. Overall, deception intention, rather than simply making counterfactual statements, appears to underlie the increased demand for cognitive control in deceivers. This can be attributed to deceivers’ need to strongly consider their opponent’s mental state—the better the deceivers’ deceptive ability, the more they will make conjectures about the mental state of their opponent with sophisticated deception and monitor conflict; the less conflict they experience while answering honestly with the intention to deceive, the more conflict may arise when the results of their deception are inconsistent with these conjectures.

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Section: Discussionmentioning

confidence: 99%

Sophisticated Deception in Junior Middle School Students: An ERP Study

Leng

Wang

et al. 2019

Front. Psychol.

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“…Autism is a highly diverse and heterogeneous spectrum of developmental disorders that are broadly characterized by impaired social interaction and communication. Numerous cognitive theories have been developed to explain the pathogenesis of autism, and these include low-level visual processing 59 and mirror neurons 60 through to predictive coding 61 . An SC theory of autism draws from the wealth of evidence for disrupted or altered SC functioning in attention and face processing, as well as parallels between neural visual development and the onset of autism.…”

Section: Autismmentioning

confidence: 99%

The influence of subcortical shortcuts on disordered sensory and cognitive processing

2020

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The very earliest stages of sensory processing have the potential to alter how we perceive and respond to our environment. These initial processing circuits can incorporate subcortical regions, such as the thalamus and brainstem nuclei, which mediate complex interactions with the brain's cortical processing hierarchy. These subcortical pathways, many of which we share with other animals, are not merely vestigial but appear to function as 'shortcuts' that ensure processing efficiency and preservation of vital life-preserving functions, such as harm avoidance, adaptive social interactions and efficient decision-making. Here, we propose that functional interactions between these higher-order and lower-order brain areas contribute to atypical sensory and cognitive processing that characterizes numerous neuropsychiatric disorders.

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“…Previous studies have uncovered the genetic link between TBR1 and increased risk for ASD (53,62). At the behavioral level, several studies have found VMI deficits (22,63,64) and motor impairment in individuals presenting with ASD (65,66). It is likely that the high expression of TBR1 in the VMI network may result in neuronal changes impacting its functionality, conferring prototypic behavioral phenotypes in ASD individuals.…”

Section: Discussionmentioning

confidence: 99%

Central neurogenetic signatures of the visuomotor integration system

Bueichekú

Aznárez-Sanado

Diez

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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Visuomotor impairments characterize numerous neurological disorders and neurogenetic syndromes, such as autism spectrum disorder (ASD) and Dravet, Fragile X, Prader–Willi, Turner, and Williams syndromes. Despite recent advances in systems neuroscience, the biological basis underlying visuomotor functional impairments associated with these clinical conditions is poorly understood. In this study, we used neuroimaging connectomic approaches to map the visuomotor integration (VMI) system in the human brain and investigated the topology approximation of the VMI network to the Allen Human Brain Atlas, a whole-brain transcriptome-wide atlas of cortical genetic expression. We found the genetic expression of four genes—TBR1, SCN1A, MAGEL2, and CACNB4—to be prominently associated with visuomotor integrators in the human cortex. TBR1 gene transcripts, an ASD gene whose expression is related to neural development of the cortex and the hippocampus, showed a central spatial allocation within the VMI system. Our findings delineate gene expression traits underlying the VMI system in the human cortex, where specific genes, such as TBR1, are likely to play a central role in its neuronal organization, as well as on specific phenotypes of neurogenetic syndromes.

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Social decision making in autism: On the impact of mirror neurons, motor control, and imitative behaviors

Cited by 59 publications

References 74 publications

Sophisticated Deception in Junior Middle School Students: An ERP Study

Sophisticated Deception in Junior Middle School Students: An ERP Study

The influence of subcortical shortcuts on disordered sensory and cognitive processing

Central neurogenetic signatures of the visuomotor integration system

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