Social Connectedness, Perceived Isolation, and Dementia: Does the Social Environment Moderate the Relationship Between Genetic Risk and Cognitive Well-Being?

Poey, Judith L.; Burr, Jeffrey A.; Roberts, J. Scott

doi:10.1093/geront/gnw154

Cited by 56 publications

(43 citation statements)

References 28 publications

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“…Contrary to our expectations social networks and the APOE e4 allele were unrelated and no interactions between them were found to be significantly associated with dementia. Hence, in line with the results presented by Brenowitz et al (2014) and Zuelsdorff et al (2013), but in contrast to those of Niti et al (2008) and Poey et al (2017), strong social networks do not seem to moderate the increased risk of dementia implied by the APOE e4 allele.…”

Section: Allsupporting

confidence: 79%

“…Among those, neither Brenowitz, Kukull, Beresford, Monsell, and Williams (2014), who investigated the incidence of mild cognitive impairment, nor Zuelsdorff et al (2013), who examined a sample of individuals with a family history of AD, could verify interactions between aspects of social relationships and the APOE e4 allele. In contrast, Poey, Burr, and Roberts (2017) found that living arrangements and perceived social support could moderate the association between the APOE e4 allele and cognitive function. Moreover, Niti, Yap, Kua, Tan, and Ng (2008) found that different kinds of leisure activities (including social activities) protected against cognitive decline and that the protective impact was particularly strong among individuals carrying the APOE e4 allele.…”

Section: Social Network and The Apoe E4 Allelementioning

confidence: 77%

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The impact of social networks and APOE ε4 on dementia among older adults: tests of possible interactions

Hasselgren

Zettergren

et al. 2018

Aging & Mental Health

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Objectives: Emerging evidence suggests that social networks may protect against the development of dementia among older adults. In this study we analysed the association between social networks, the apolipoprotein E (APOE) e4 allele, and dementia. We also investigated whether there were gender-specific patterns in this respect. Method: The analyses used population-based longitudinal data from Gothenburg, Sweden: the H70 Birth Cohort Study and the Prospective Population Study on Women (PPSW). A total of 580 individuals born in 1930 underwent semi-structured neuropsychiatric examinations in 2000-2001. Follow-up examinations were carried out in 2005-2006 and 2009-2010. The timing of dementia onset was analysed using Cox proportional hazards regression. Results: The presence of the APOE e4 allele affected the risk of developing dementia in both genders. Among women, distant social networks had a protective effect on dementia, while among men the significant associations between close social networks and dementia did not remain after controlling for covariates. Significant interactions between social networks and the APOE e4 allele were not found. Conclusion: Strong social networks do not seem to moderate the increased risk of dementia implied by the APOE e4 allele. Nevertheless, our results underline the importance of strong social networks in postponing dementia onset and indicate that their impact may differ among men and women.

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Section: Allsupporting

confidence: 79%

Section: Social Network and The Apoe E4 Allelementioning

confidence: 77%

The impact of social networks and APOE ε4 on dementia among older adults: tests of possible interactions

Hasselgren

Zettergren

et al. 2018

Aging & Mental Health

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“…Earlier studies on social factors and cognitive decline in middle‐ and older‐aged adults have commonly followed a single measurement approach . Among the few ones in which researchers examined social isolation and loneliness simultaneously, the evidence has yielded mixed results . For instance, findings from the English Longitudinal Study of Ageing revealed that social isolation was related to decreased episodic memory and verbal fluency after a 4‐year follow‐up period, whereas loneliness was found to be associated with poorer immediate and delayed recall over time .…”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15] Among the few ones in which researchers examined social isolation and loneliness simultaneously, the evidence has yielded mixed results. 10,[16][17][18][19][20] For instance, findings from the English Longitudinal Study of Ageing revealed that social isolation was related to decreased episodic memory and verbal fluency after a 4-year follow-up period, whereas loneliness was found to be associated with poorer immediate and delayed recall over time. 17 By contrast, Wilson et al, 21 using data from a longitudinal cohort study of 823 older adults, reported that loneliness was linked to a more rapid decline in semantic memory rather than episodic memory.…”

Section: Introductionmentioning

confidence: 99%

Are loneliness and social isolation associated with cognitive decline?

Lara

Caballero

Rico-Uribe

et al. 2019

Int J Geriat Psychiatry

247

169

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Objective This study aimed to examine the association of loneliness and social isolation on cognition over a 3‐year follow‐up period in middle‐ and older‐aged adults. Methods Data from a Spanish nationally representative sample were analyzed (n = 1691; aged 50 years or older). Loneliness, social isolation, and cognition (immediate recall, delayed recall, verbal fluency, forward digit span, backward digit span, and a composite cognitive score) were assessed both at baseline and at follow‐up. Adjusted generalized estimating equations models were performed. Results Loneliness was significantly associated with lower scores in the composite cognitive score, immediate and delayed recall, verbal fluency, and backward digit span (B = −0.14 to B = −3.16; P < .05) and with a more rapid decline from baseline to follow‐up in two out of six cognitive tests. Higher social isolation was associated with lower scores in the composite cognitive score, verbal fluency, and forward digit span (B = −0.06 to B = −0.85; P < .05). The effect of loneliness and social isolation on cognition remained significant after the exclusion of individuals with depression. Conclusions Both loneliness and social isolation are associated with decreased cognitive function over a 3‐year follow‐up period. The development of interventions that include the enhancement of social participation and the maintenance of emotionally supportive relationships might contribute to cognitive decline prevention and risk reduction.

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“…The act of talking with someone is a fundamental action for building social connectedness and reducing the feeling of social isolation. Social disconnectedness and perceived social isolation are likely to cause health risks [1][2][3], such as dementia [4,5], depression [6], and early death [7]. Therefore, it is important to increase opportunities for elderly people to have dialogues with other people.…”

Section: Introductionmentioning

confidence: 99%

Twin-Robot Dialogue System with Robustness against Speech Recognition Failure in Human-Robot Dialogue with Elderly People

Iio

Yoshikawa

Chiba³

et al. 2020

Applied Sciences

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As agents, social robots are expected to increase opportunities for dialogue with the elderly. However, it is difficult to sustain a dialogue with an elderly user because speech recognition frequently fails during the dialogue. Here, to overcome this problem, regardless of speech recognition failure, we developed a question–answer–response dialogue model. In this model, a robot took initiative in the dialogue by asking the user various questions. Moreover, to improve user experience during dialogue, we extended the model such that two robots could participate in the dialogue. Implementing these features, we conducted a field trial in a nursing home to evaluate the twin-robot dialogue system. The average word error rate of speech recognition was 0.778. Despite the frequently high number of errors, participants talked for 14 min in a dialogue with two robots and felt slightly strange during the dialogue. Although we found no significant difference between a dialogue with one robot and that with two robots, the effect size of the difference in the dialogue time with one robot and that with two robots was medium (Cohen’s d = −0.519). The results suggested that the presence of two robots might likely encourage elderly people to sustain the talk. Our results will contribute to the design of social robots to engage in dialogues with the elderly.

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Social Connectedness, Perceived Isolation, and Dementia: Does the Social Environment Moderate the Relationship Between Genetic Risk and Cognitive Well-Being?

Abstract: The results support the need to consider the social context when examining cognitive well-being in later life. These findings also indicate a need for the development of policies and services that promote a rich social environment.

Cited by 56 publications

References 28 publications

The impact of social networks and APOE ε4 on dementia among older adults: tests of possible interactions

The impact of social networks and APOE ε4 on dementia among older adults: tests of possible interactions

Are loneliness and social isolation associated with cognitive decline?

Twin-Robot Dialogue System with Robustness against Speech Recognition Failure in Human-Robot Dialogue with Elderly People

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