Social and environmental influences on opioid sensitivity in rats: importance of an opioid’s relative efficacy at the mu-receptor

Smith, Mark A.; Chisholm, Kara A.; Bryant, Paul A.; Greene, Jennifer L.; McClean, Jacob M.; Stoops, William W.; Yancey, David L.

doi:10.1007/s00213-005-2218-2

Cited by 50 publications

(42 citation statements)

References 51 publications

(61 reference statements)

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“…For example, neither methamphetamine-nor morphine-induced CPP is altered reliably by isolation housing (Smith et al, 2005;Thiriet et al, 2011), although one study found that SC mice display greater heroin CPP than EC mice ). In the case of alcohol, isolation housing reliably increases free-access intake in both rats and rhesus monkeys (Kraemer and McKinney, 1985;ProcopioSouza et al, 2011), and similar results are obtained with diazepam (Wolffgramm and Heyne, 1991).…”

Section: Psychosocial Influences and Abused Drugsmentioning

confidence: 99%

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

2013

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Section: Psychosocial Influences and Abused Drugsmentioning

confidence: 99%

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

2013

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“…For instance, enriched female rats were more sensitive to the aversive effects of the mu opioid morphine in the conditioned taste aversion paradigm [10], and enriched male rats were more sensitive to the rewarding effects of morphine in the conditioned place preference procedure [11]. Similarly, we reported that enriched male rats were more sensitive to the effects of the mixedaction opioids butorphanol and nalbuphine in the conditioned place preference procedure and in a test of thermal antinociception [12]. We also reported that enriched male rats were more sensitive to the effects of the kappa opioid spiradoline on measures of antinociception, diuresis, and conditioned place preference [13].…”

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confidence: 56%

“…In contrast to these findings, isolated male rats were more sensitive to the effects of morphine on locomotor activity and displayed greater locomotor sensitization following repeated morphine treatment [11]. Furthermore, isolated and enriched male rats did not differ in their oral consumption of morphine in a two-bottle preference test [14], and did not differ in sensitivity to the effects of morphine and levorphanol in a thermal antinociception test [12].Of those studies examining the effects of enrichment on opioid sensitivity, only one has used females [10]. This is a potentially significant issue, given evidence that males and females may respond differently to social and environmental manipulations.…”

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confidence: 74%

“…Using a protocol established previously in male rats [12,13], environmental enrichment did not influence sensitivity to the effects of a variety of opioid receptor agonists in female rats. Across a range of doses and two stimulus intensities, isolated and enriched females did not differ in sensitivity to the antinociceptive effects of the mu opioids morphine and levorphanol, the kappa opioids spiradoline and U69,593, and the mixed-action opioids buprenorphine and butorphanol.…”

Section: Discussionmentioning

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Effects of environmental enrichment on sensitivity to mu, kappa, and mixed-action opioids in female rats

Smith

Cole

Gergans

et al. 2008

Physiology & Behavior

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Several studies report that environmental enrichment enhances sensitivity to opioid receptor agonists in male rats. Very few studies have examined the effects of enrichment in female rats, and thus it is not clear whether females are similarly sensitive to these effects. Consequently, the purpose of the present study was to examine the effects of environmental enrichment on sensitivity to representative mu, kappa, and mixed-action opioids in female rats. Following a protocol established in males, females were obtained at weaning and randomly assigned to two groups immediately upon arrival: isolated rats were housed individually with no visual or tactile contact with other rats; enriched rats were housed in groups of four in large cages and given various novel objects on a regular basis. After 6 weeks under these conditions, the antinociceptive effects of mu (morphine, levorphanol), kappa (spiradoline, U69,593), and mixed-action (buprenorphine, butorphanol) opioids were examined in a warm-water, tail-withdrawal procedure. All the opioids examined produced dose-dependent increases in antinociception; however, no differences in opioid sensitivity were observed between the two groups. To determine whether these findings were consistent across behavioral endpoints, the antidiuretic effects of representative mu opioids, and the diuretic effects of representative kappa opioids, were examined in female rats reared under isolated or enriched conditions for 10 weeks. Similar to that seen in the antinociceptive experiment, no significant differences in opioid sensitivity were observed between groups. These data indicate that environmental enrichment does not alter sensitivity to the effects of opioid receptor agonists in female rats, and suggest that females may respond differently to environmental enrichment than males. Keywordsantidiuresis; antinociception; diuresis; enrichment; female; isolation; opioid; rat A large number of studies reveal that environmental manipulations during critical periods in development can influence the physical maturation of the nervous system and produce functional effects on behavior. For example, male rats reared under conditions of environmental enrichment (i.e., conditions in which rats were housed together in large groups and provided with novel objects on a regular basis) had greater cortical mass [1,2], had greater dendritic branching on cortical neurons [3,4], and performed better in learning and memory tasks [5,6] than animals reared in isolation under impoverished conditions. Interestingly, these same types of manipulations can also influence an organism's sensitivity to the neurochemical Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be ...

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Social environment alters opioid‐induced hyperalgesia and antinociceptive tolerance in adolescent mice

Bates

Emery

Wellman

et al. 2016

European Journal of Pain

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Social and environmental influences on opioid sensitivity in rats: importance of an opioid’s relative efficacy at the mu-receptor

Abstract: These findings may be taken as evidence that enriched rats are more sensitive than isolated rats to the effects of lower-efficacy mu-opioids and that social and environmental enrichment leads to functional alterations in opioid receptor populations.

Cited by 50 publications

References 51 publications

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

Effects of environmental enrichment on sensitivity to mu, kappa, and mixed-action opioids in female rats

Social environment alters opioid‐induced hyperalgesia and antinociceptive tolerance in adolescent mice

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