Social and emotional adjustment in young survivors of childhood cancer

Stam, Heleen; Ma, Grootenhuis

doi:10.1007/s005200100271

Cited by 77 publications

(76 citation statements)

References 53 publications

(195 reference statements)

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“…This is not surprising, given the fact that the medical variables were assessed rather roughly and because it was too short after termination of treatment to find late effects of treatment. The limited impact of medical variables on HRQoL has been found in many studies among survivors of childhood cancer [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…The enormous increase in survival [4][5][6][7][8] has heightened the need to investigate the consequences of childhood cancer. An increasing number of studies have been directed at assessing Health Related Quality of Life (HRQoL) in long-term survivors, and considerable literature has been devoted to the pediatric patients and their parents during cancer treatment [1,9,10]. Less is known about what happens in the first few years after treatment in the run-up to long-term survivorship.…”

Section: Introductionmentioning

confidence: 99%

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Longitudinal assessment of health‐related quality of life in preschool children with non‐CNS cancer after the end of successful treatment

Maurice‐Stam

Oort

Brons

et al. 2007

Pediatric Blood & Cancer

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BackgroundThe aim of the study was to access Health Related Quality of Life (HRQoL) in preschool cancer survivors during the first 3 years of continuous remission after the end of successful treatment, and to identify predictors of HRQoL.ProcedureParent‐reported HRQoL was assessed in 53 preschool children treated successfully for cancer, using the TAPQOL and compared with norm data. Longitudinal mixed models analyses were performed to investigate to what extent demographic and medical variables and parental psychological distress were predictive of HRQoL over time.ResultsTwo months after the end of successful cancer treatment, survivors showed significantly (P < 0.01) more problem behavior and anxiety, and scored significantly worse (P < 0.01) on sleeping, motor functioning, positive mood and liveliness than the norm. One year after the end of treatment survivors still showed significantly (P < 0.01) more anxiety and worse motor functioning. The level of HRQoL in survivors had normalized 2 and 3 years after the end of treatment. Longer duration of treatment, bad prognosis and greater parental psychological distress were associated with worse scores on the Physical Component Score of the TAPQOL. Medical variables and parental psychological distress were not associated with the Mental Component Score.ConclusionsSurvivors adjusted well to the cancer experience and HRQoL improved with time. Despite overall resilience in survivors over time, physical as well as psychosocial monitoring in follow‐up is recommended. Standard aftercare should preferably include psychosocial screening, education, and counseling directed at both survivors and parents. Pediatr Blood Cancer 2008;50:1047–1051. © 2007 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Longitudinal assessment of health‐related quality of life in preschool children with non‐CNS cancer after the end of successful treatment

Maurice‐Stam

Oort

Brons

et al. 2007

Pediatric Blood & Cancer

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“…They are confronted with a life-threatening disease mostly implying extensive treatment with negative side-effects and the risk of negative long-term consequences. Considerable literature has been devoted to the long-term adjustment of the child [2][3][4]. It can be concluded that dealing with childhood cancer is a dramatic event that could influence physical and psychosocial functioning long time after termination of the treatment [2,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, post-traumatic stress symptoms appeared to be common in families of childhood cancer; among survivors of childhood cancer, as well as among their parents [7][8][9][10]. Nevertheless, many long-term survivors of childhood cancer turned out to function well [11,12](see reviews by Langeveld et al [3] and Stam et al [4]). This appeared also to be true for their parents; overall, most of them did not experience more emotional disturbances than healthy controls [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Health‐related quality of life in children and emotional reactions of parents following completion of cancer treatment

Stam

Grootenhuis

Brons

et al. 2005

Pediatric Blood & Cancer

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BackgroundCompleting therapy is one of the major transitions in care in the practice of pediatric oncology and, therefore, deserves special consideration. The purpose of the study was to investigate health‐related quality of life (HRQOL) of pediatric patients, and emotional reactions of their parents, shortly after the end of successful treatment.MethodsHRQOL of 126 patients, aged 1–15 years, on average 2 months after the end of successful treatment, was assessed with the TNO‐AZL Pre‐school Quality of life Questionnaire and the TNO‐AZL Children's Quality of life Questionnaire. Emotional adjustment of 124 mothers and 111 fathers was assessed with the General Health Questionnaire and the Situation Specific Emotional Reaction Questionnaire. The outcomes of the patients and parents were compared with norm data by means of one sample t‐tests, one sample sign‐tests or binomial tests.ResultsAll age groups, except patients aged 8–11 years, experienced worse HRQOL than the norm with respect to motor functioning. In addition, pre‐school patients were rated worse on sleeping, appetite, stomach, skin, problem behavior, anxiety, and liveliness, and patients aged 6–7 years on autonomy and cognitive functioning. Parents reported more psychological distress than the norm. Compared to parents whose children were 1–5 years after cancer treatment, they suffered more from feelings of loneliness, helplessness, and uncertainty.ConclusionsA few months after the end of successful cancer treatment, both patients and parents appeared to experience worse well‐being than the norm to a clinically relevant extent. Supporting patients and parents should not stop when treatment ends. Pediatr Blood Cancer 2006;47:312–319. © 2005 Wiley‐Liss, Inc.

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“…5,13,[32][33][34][35][36] In addition, some reports suggest that survivors of childhood cancer in general, and brain tumors in particular, tend to be less competent socially and more isolated socially compared with their peers. 33,[37][38][39][40] However, with one exception, 35 studies have been limited by small sample sizes of either a single diagnostic group or a combination of all cancer types together, few have used a comparison group of individuals without cancer, and some have included only adult survivors. Small samples do not permit specific comparisons among survivors with diverse diagnoses and treatment modalities, whereas including only survivors age 18 years or older limits the possibility of identifying highrisk survivors who may benefit from early educational rehabilitation.…”

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confidence: 99%

Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics

Barrera

Shaw

Speechley

et al. 2005

Cancer

285

265

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The protein human CC chemokine ligand 2 (CCL2, also known as monocyte chemoattractant protein 1 or MCP‐1) has been synthesized using a combination of solid phase peptide synthesis (SPPS) and native chemical ligation (NCL). The thioester‐peptide segment was synthesized using the sulfonamide safety‐catch linker and 9‐fluorenylmethoxycarbonyl (Fmoc) SPPS, and pseudoproline dipeptides were used to facilitate the synthesis of both CCL2 fragments. After assembly of the full‐length peptide chain by NCL, a glutathione redox buffer was used to fold and oxidize the CCL2 protein. Synthetic human CCL2 binds to and activates the CCR2 receptor on THP‐1 cells, as expected. CCL2 was crystallized and the structure was determined by X‐ray diffraction at 1.9‐Å resolution. The structure of the synthetic protein is very similar to that of a previously reported structure of recombinant human CCL2, although the crystal form is different. The functional CCL2 dimer for the crystal structure reported here is formed around a crystallographic twofold axis. The dimer interface involves residues Val9‐Thr10‐Cys11, which form an intersubunit antiparallel β‐sheet. Comparison of the CCL2 dimers in different crystal forms indicates a significant flexibility of the quaternary structure. To our knowledge, this is one of the first crystal structures of a protein prepared using the sulfonamide safety‐catch linker and NCL. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 350–359, 2010. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com

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Social and emotional adjustment in young survivors of childhood cancer

Cited by 77 publications

References 53 publications

Longitudinal assessment of health‐related quality of life in preschool children with non‐CNS cancer after the end of successful treatment

Longitudinal assessment of health‐related quality of life in preschool children with non‐CNS cancer after the end of successful treatment

Health‐related quality of life in children and emotional reactions of parents following completion of cancer treatment

Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics

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