Sobre o Autismo, Neuroinflamação e Modelos Animais para o Estudo de Autismo:

Bernardi, Maria Martha; Kirsten, Thiago Berti; Trindade, Mácio Oliveira

doi:10.34024/rnc.2012.v20.8304

Cited by 6 publications

(6 citation statements)

References 62 publications

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“…The etiology and clinical features of ASD are complex and extremely heterogeneous. Several risk potentials such as genetic (Banerjee et al, 2014), epigenetic (Haque et al, 2009), environmental, and/or immunological (Anderson, 2012; Bernardi et al, 2012) have been identified as causal factors for the development of ASD, thus considering a multifactorial disorder (Anderson, 2015).…”

Section: Discussionmentioning

confidence: 99%

6‐Shogaol improves behavior and memory in Wistar rats prenatally exposed to lipopolysaccharide

Rosa

Medeiros

Oliveira

et al. 2021

Intl J of Devlp Neuroscience

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Objective 6‐Shogaol, bioactive compound of Zingiber officinale Roscoe, has anti‐inflammatory, antioxidant, and neuroprotective properties. The objective of the present study was to verify the effect of 6‐shogaol on behavioral parameters in a preclinical model based on a maternal immune activation (MIA) by lipopolysaccharide (LPS). Methodology Twelve pregnant Wistar rats received 100‐μg/kg LPS or saline solution on gestational day (GD) 9.5. Male offspring participated in the study and in the postnatal day (PND) 30 and 55 were supplemented with 6‐shogaol or saline solution, by gavage at a dose of 10 mg/kg/day, orally for 5 days. In the PND 35 and 60 was performed the behavioral tests: grooming, crossing, and rearing that evaluated repetitive movements, anxiety, and interest in the new, respectively, and the inhibitory avoidance test that evaluated short‐term (STM) and long‐term memory (LTM). Result Prenatal exposure to LPS increased the grooming and crossing episodes at different ages and reduced rearing episodes in PND 37. Treatment with 6‐shogaol reversed these parameters. In the inhibitory avoidance test, an improvement of memory was identified with 6‐shogaol in the STM and LTM at both ages comparing training and test session of treated groups and between groups. Conclusion Administration of 6‐shogaol reverses the stereotypy, exploratory behavior, and memory impairment in prenatal LPS‐exposed offspring, acting as a promising therapeutic component against brain disorders associated with the process of MIA.

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Section: Discussionmentioning

confidence: 99%

6‐Shogaol improves behavior and memory in Wistar rats prenatally exposed to lipopolysaccharide

Rosa

Medeiros

Oliveira

et al. 2021

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

show abstract

“…Also, there is a necessity of immediate and adequate followup and treatment to pregnant women in cases of viral infections 15 . However, it is worth noting that the causes of ASD are still unknown, but there is a strong correlation with signs of being multigeneous and multifactorial.…”

Section: Maternal Viral Infection and Asdmentioning

confidence: 99%

“…This maternal environment exposed to infections and inflammations has repercussions on a variety of inflammatory cytokines 4,15 . The inflammatory, neurochemical, and neural hypoperfusion abnormalities seem to be the most consistent correlations for the involvement of ASD in the descendants 30 .…”

Section: Maternal Immune Activation and Asdmentioning

confidence: 99%

Possible risk of fetal development of autism in pregnant women infected by SARS-CoV-2

Oliveira¹,

Júnior²,

Aragão

2021

Rev Neurocienc

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Introduction. In March 2020, the World Health Organization (WHO) announced the emergence of a global pandemic, COVID-19. A disease triggered by the new coronavirus infection (SARS-CoV-2). More recent findings indicate that the gestational period makes the mother and her offspring more susceptible to the new coronavirus and the rapid progression to the critical stage of the disease. The maternal organism presents a certain degree of immunological and cardiorespiratory deficiency due to physiological adaptations to the gestational period and, consequently, if affected by prenatal infections caused by viruses, they lead to an exacerbated Maternal Immune Activation (MIA), thus contributing to alterations in maternal-fetal neurogenesis, fetal myelinization, and is directly involved in the pathogenesis of neurodevelopmental disorders in the offspring, especially autism. Objective. This study hypothesizes that maternal COVID-19 infections during pregnancy are a potential risk for the offspring to develop Autism Spectrum Disorder. Conclusion. The exposure to viral infectious agents during the gestational period leads to exacerbated maternal immune activation. It contributes to alterations in maternal-fetal neurogenesis and is directly involved in the pathogenesis of neurodevelopmental disorders, being correlated to the predisposition to affective and psychiatric disorders in the offspring. Therefore, greater attention should be given to the offspring of pregnant women infected by COVID-19, since prenatal infectious processes have a strong correlation with the prevalence of Autistic Spectrum Disorder in the offspring.

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“…Several brain regions are involved in the genesis of ASD, including the limbic system, among them the hippocampus, amygdala, prefrontal areas, and cerebellum [17, 18]. Abnormalities can be verified in the prenatal period, notably in brain regions that develop late in neurogenesis.…”

Section: Introductionmentioning

confidence: 99%

6-Shogaol Exerts a Neuroprotective Factor in Offspring after Maternal Immune Activation in Rats

Rosa¹,

Medeiros²,

Oliveira³

et al. 2021

Dev Neurosci

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6-Shogaol is one of the main active phenolic components of ginger and has neuroprotective effects by protecting brain against the oxidative stress and regulate the levels of neurotrophic factors. The objective of the present study was to verify the effect of 6-shogaol on neurochemical parameters in offspring after maternal immune activation by lipopolysaccharide (LPS) in rats. Twelve pregnant Wistar rats received 100 μg/kg of LPS or saline solution on the gestational day 9.5. Male offspring participated in the study and from the postnatal days (PND) 30 and 55, respectively, they were supplemented with 6-shogaol or saline solution, by gavage at a dose of 10 mg/kg/day, orally for 5 days. In PND 37 and 62, analysis of kinase signaling regulated by extracellular signal 1/2 (ERK 1/2), levels of neurotrophic factor derived from the brain (BDNF), and neuron-specific enolase (NSE), lipid and protein oxidative damage was evaluated by 4-hydroxy-2-nonenal (HNE) and 3-nitrotyrosine (3-NT), respectively, and myeloperoxidase (MPO) activity was performed in the hippocampus. Prenatal exposure to LPS significantly decreased ERK and BDNF levels in PND 37 and 62, increased NSE levels and lipid damage in rats in PND 37, and increased 3-NT level in rats in PND 62. With treatment using 6-shogaol, an increase in ERK and BDNF levels was identified in PND 37 and 62 and a reduction in HNE and MPO activity in rats in PND 37 and 62, respectively. 6-Shogaol positively increased markers of neuronal growth, plasticity and synaptic activity and reduced oxidative damage in the hippocampus in an animal model of autism by maternal immune activation.

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Sobre o Autismo, Neuroinflamação e Modelos Animais para o Estudo de Autismo:

Cited by 6 publications

References 62 publications

6‐Shogaol improves behavior and memory in Wistar rats prenatally exposed to lipopolysaccharide

6‐Shogaol improves behavior and memory in Wistar rats prenatally exposed to lipopolysaccharide

Possible risk of fetal development of autism in pregnant women infected by SARS-CoV-2

6-Shogaol Exerts a Neuroprotective Factor in Offspring after Maternal Immune Activation in Rats

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