So-called “non-classic” ciliated muconodular papillary tumors: a comprehensive comparison of the clinicopathological and molecular features with classic ciliated muconodular papillary tumors

Zheng, Qiang; Luo, Rongkui; Jin, Yan; Shen, Xueyan; Shan, Ling; Shen, Lei; Hou, Yayi; Li, Yuan

doi:10.1016/j.humpath.2018.07.029

Cited by 27 publications

(44 citation statements)

References 15 publications

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“…Of all the 99 patients, twenty-three were diagnosed with adenocarcinoma originally (23.0%) [6,[17][18][19]5,21,23,24], two were suspected of malignant tumors (2.0%) [6]. Furthermore, some cases were just pathologically descriptive diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…But in recent years, many cases have been reported with the increasing recognition of this entity . Kamata reported 10 cases in 2015 [6], and then both Chang (Western country cohort) [18] and Zheng [19] reported more than 20 cases in 2018. So far, nearly 100 cases have been reported in the English literatures and most of these patients are in East Asia countries.…”

Section: Introductionmentioning

confidence: 99%

“…The entity is commonly surrounded by extracellular mucin pools in the peripheral lung. Some cases did not fit all diagnostic criteria, such as absent papillary architecture or lack of mucinous and/or ciliated cells, but shared the histological feature of bilayered bronchiolar-type proliferation and continuous layer of basal cells, which were termed as "non-classic" CMPTs by Zheng et al [19]. Moreover, both Zheng et al [19] and Chang et al [18] have found these lesions also shared genomic abnormalities.…”

Section: Introductionmentioning

confidence: 99%

“…Until now, many evidence shown that BA is a neoplastic disease, but the histogenesis and biological behavior is still unknown and molecular data is limited. Recent studies have identified BRAF, ALK, EGFR, KRAS, HRAS and AKT1 mutations in BA [7,8,[13][14][15][16]18,19,25,26]. Among them, the most commonly driver mutations are BRAF V600E mutations.…”

Section: Introductionmentioning

confidence: 99%

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Bronchiolar Adenoma with ERBB2 exon 20 insertion: report of four cases and review of the literature

Zheng

et al. 2020

Preprint

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Objectives: Ciliated muconodular papillary tumor (CMPT) is a rare peripheral lung tumor and is considered to be a subtype of Bronchial Adenoma (BA). Although recent studies have suggested that BA belongs to a neoplastic disease, the complete histogenesis of BA is not fully understood and molecular data is limited. Methods: We demonstrated clinicopathologic features of four cases of BA and performed immunohistochemical and next generation sequencing to characterize its molecular features. Besides, a review of previous literature was done to comprehensively conclude the molecular characteristic of this disease.Results: We found ERBB2, EGFR, BRAF and AKT1 mutations in BAs. It’s the first time that ERBB2 exon 20 insertion has been reported in BA. Conclusion: BA is a rare pulmonary disease mainly affected elderly Asian patients. More and more abnormal molecular changes were observed, which confirmed the neoplastic nature of BA. However, it also raise the debate about BA’s biological behavior.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bronchiolar Adenoma with ERBB2 exon 20 insertion: report of four cases and review of the literature

Zheng

et al. 2020

Preprint

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“…However, in recent years, many cases have been reported with increasing recognition of this tumor . Kamata reported 10 cases in 2015 [6] and both Chang (Western country cohort) [18] and Zheng [19] reported more than 20 cases in 2018. To date, nearly 100 cases have been reported in the literature and most of these patients reside in East Asia countries.…”

mentioning

confidence: 99%

Detection of a novel gene mutation, ERBB2 exon 20 insertion, in bronchial adenoma using next-generation sequencing and a review of the literature

Zheng

et al. 2020

Preprint

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Objectives: Ciliated muconodular papillary tumor (CMPT) is a rare peripheral lung tumor and is a subtype of bronchial adenoma (BA). Although recent studies have suggested that BA is a neoplastic disease, the complete histogenesis of BA is not fully understood and molecular data are limited. Methods: We examined the clinicopathological features of four patients with BA and performed immunohistochemical analysis and next-generation sequencing to characterize the molecular features of BA. A review of the previous literature was also undertaken to comprehensively conclude the molecular characteristics of this disease. Results: From previous studies and the present study, 99 BA /CMPT cases have been reported to date, with most of the patients from East Asia (77/99, 77.8%). The median age was 64 years old and the ages ranged from 19 to 84 years. The proportion of males and females was close, being approximately 1:1.3. From the computed tomography images, the BA /CMPT tumor usually presented as a peripheral solid mass, part-solid nodules, or ground-glass opaque with an irregular border and occasional central cavities. ERBB2, EGFR, BRAF, and AKT1 mutations were found on the computed tomography images of the BAs. To the best of our knowledge, this is the first study to report about ERBB2 exon 20 insertion in BA. Conclusion: BA /CMPT is a rare pulmonary disease that mainly affects elderly Asian patients. Many abnormal molecular changes were found, which confirmed the neoplastic nature of BA /CMPT. However, it also added to the debate regarding the biological behavior of BA /CMPT.

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Bronchiolar adenoma/ciliated muconodular papillary tumour: advancing clinical, pathological, and imaging insights for future perspectives

Liu,

Xu,

Wang

et al. 2024

Clinical Radiology

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So-called “non-classic” ciliated muconodular papillary tumors: a comprehensive comparison of the clinicopathological and molecular features with classic ciliated muconodular papillary tumors

Cited by 27 publications

References 15 publications

Bronchiolar Adenoma with ERBB2 exon 20 insertion: report of four cases and review of the literature

Bronchiolar Adenoma with ERBB2 exon 20 insertion: report of four cases and review of the literature

Detection of a novel gene mutation, ERBB2 exon 20 insertion, in bronchial adenoma using next-generation sequencing and a review of the literature

Bronchiolar adenoma/ciliated muconodular papillary tumour: advancing clinical, pathological, and imaging insights for future perspectives

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