SNPs in the porcine PPARGC1a gene: Interbreed differences and their phenotypic effects

Stachowiak, Monika; Szydłowski, M.; Cieślak, J.; Świtoński, M.

doi:10.2478/s11658-006-0066-7

Cited by 24 publications

(15 citation statements)

References 14 publications

(21 reference statements)

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“…The significantly lower percentage of type IIb glycolytic muscle fibres in the T/A compared to the T/T genotype suggests that the AA change could have a positive impact on PPARGC1A protein stability and/or MEF2C binding and functioning. A breed specific association with feed conversion has been previously reported for this SNP, while no relation with carcass composition was found in another study (Jacobs et al, 2006;Stachowiak et al, 2007). Our results showed significant associations with a few carcass composition parameters, but no consistent conclusions could be drawn from these data.…”

Section: Discussioncontrasting

confidence: 92%

“…Another study reported a breed specific association with backfat, but our results could not confirm this (Stachowiak et al, 2007). SNP16 is a silent mutation located in exon 8 and is not therefore expected to have a major impact on PPARGC1A expression or functioning, although it could have an influence on the mRNA level.…”

Section: Discussioncontrasting

confidence: 84%

“…PPARGC1A gene expression was shown to vary between and within porcine backfat and longissimus dorsi muscle (MLD), which are tissues with different demands regarding technological and eating quality (Erkens et al, 2006). Different single nucleotide polymorphisms (SNPs), in both coding and regulatory regions of PPARGC1A, have been independently associated with several fat characteristics in pigs, with milk fat yield in cattle and with obesity/type II diabetes in humans (Ek et al, 2001;Weikard et al, 2005;Jacobs et al, 2006;Vimaleswaran et al, 2006;Stachowiak et al, 2007). However, the associations found in pigs were only breed specific and could not be confirmed in other pig populations.…”

mentioning

confidence: 99%

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Association analysis of PPARGC1A mutations with meat quality parameters in a commercial hybrid pig population

Erkens¹,

Smet²,

Maagdenberg³

et al. 2010

CZECH J ANIM SCI

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Peroxisome proliferator-activated receptor γ coactivator 1α (PPARGC1A) is a promising candidate gene for selection on meat and carcass quality traits in the pig industry. In the pig, several SNPs have been reported in both coding and regulatory regions of this gene, some of which were associated with fat characteristics, but none of these associations have been confirmed and many SNPs have not yet been evaluated. Therefore, 18 PPARGC1A SNPs were genotyped in 65 slaughter pigs of a commercial hybrid population and used in an association analysis with multiple muscle and carcass traits. Several SNPs located in the 3'UTR and exon 8 and 9 of PPARGC1A were significantly (P < 0.05-0.001) associated with various carcass composition, tenderness and muscle fibre traits. They could potentially serve as DNA selection markers, if their impact was to be confirmed by a functional analysis.

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Section: Discussioncontrasting

confidence: 92%

Section: Discussioncontrasting

confidence: 84%

mentioning

confidence: 99%

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Association analysis of PPARGC1A mutations with meat quality parameters in a commercial hybrid pig population

Erkens¹,

Smet²,

Maagdenberg³

et al. 2010

CZECH J ANIM SCI

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show abstract

“…In pigs, for example, PPARGC1A has been widely studied and found to be a major gene underlying variations in production traits. Stachowiak et al (2007) reported an SNP in exon 8 of porcine PPARGC1A associated with feed conversion ratio, abdominal fat and BFT. In dairy cattle, a significant association between an SNP in intron 9 of PPARGC1A and milk fat yield was observed by Weikard et al (2005).…”

Section: Discussionmentioning

confidence: 99%

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

et al. 2015

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ABSTRACT. Backfat thickness (BFT) and ribeye area (REA) are important production traits but, because they are measured late in the animal's life, they have not been efficiently included in breeding programs. The aim of this study was to evaluate whether single nucleotide polymorphisms (SNPs) mapped to the leptin, PPARGC1A, PSMC1, CRH, and FABP4 genes, which influence BFT and REA in Canchim cattle, a composite beef breed (5/8 Charolais + 3/8 Zebu). BFT and REA phenotypic records were obtained by ultrasound measurements from 18-month-old animals. All SNP markers were genotyped by restriction fragment length polymorphismpolymerase chain reaction. Restricted maximum likelihood analysis revealed that the non-synonymous SNP located in exon 2 of the FABP4 gene has an additive effect on BFT (P ≤ 0.05). Significant allele substitution 16668©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 16667-16674 (2015) G. Veneroni-Gouveia et al. effects showed that the substitution of G by A may lead to a decrease of 0.1055 mm in mean BFT. This information can be used for inclusion of this trait-associated marker in commercial SNP panels.

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“…In pigs, PPARGC1A is considered a candidate gene for production traits. Stachowiak et al (2007) have found an SNP in this gene associated with fat-related traits in swine. Weikard et al (2005) have identified PPARGC1A in cattle as a positional candidate gene for its location in a region of bovine chromosome 6 that underlies a previously described QTL for fat deposition in milk.…”

Section: Resultsmentioning

confidence: 99%

Candidate genes for production traits in Nelore beef cattle

Tizioto

Meirelles²,

Tulio³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Meat quality is an important trait for the beef industry. Backfat thickness, ribeye area, and shear force are traits measured late in life, and the investigation of molecular markers associated with these traits can help breeding programs. In cattle, some polymorphisms have been related to production traits. Thus, the purpose of this study was to assess the presence of polymorphisms in the candidate genes insulinlike growth factor 1 (IGF1), fatty acid-binding protein 4 (FABP4), and peroxisome proliferative active receptor gamma coactivator 1 A (PPARGC1A) and associate them with production traits in reference families of Nelore cattle. We used 270 steers descendent from 20 sires that were chosen to represent variability in this breed. The investigation of marker effects on the traits was performed using a mixed model under the restricted maximum likelihood method. A significant allele substitution effect was found for IGF1 and yearling weight (P ≤ 0.017). 4139©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 11 (4): 4138-4144 (2012) Candidate genes in NeloreThe mean allele substitution effect was 6.9 kg, with the 229 allele associated with reduced yearling weight in this Nelore population.

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SNPs in the porcine PPARGC1a gene: Interbreed differences and their phenotypic effects

Cited by 24 publications

References 14 publications

Association analysis of PPARGC1A mutations with meat quality parameters in a commercial hybrid pig population

Association analysis of PPARGC1A mutations with meat quality parameters in a commercial hybrid pig population

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

Candidate genes for production traits in Nelore beef cattle

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