Snoring Is Associated With Increased Risk of Stroke: A Cumulative Meta-Analysis

Abstract

Background: Several studies have suggested that snoring is associated with an increased risk of stroke; however, the results are inconsistent. We aim to conduct a systematic review and meta-analysis of observational studies assessing the association between snoring and the risk of stroke in adults.Methods: We searched PubMed for relevant studies. A random-effect model was adopted to summary relative risks (RRs), and forest plots from a cumulative meta-analysis method were used for a better presentation of how the pooled RRs changed as updated evidence accumulated.Results: The literature search yielded 16 articles that met our inclusion criteria, and a total of 3,598 stroke patients and 145,901 participants were finally included in our analysis. A consistent trend toward association was found after the initial discovery, and the summary analysis indicated that snoring is associated with a 46% (RR, 1.46; 95%CI, 1.29–1.63; p < 0.001) increased risk of stroke.Conclusions: Snoring is associated with a significantly increased risk for stroke, up to 46%. The importance of the current study lies in that we provide an imputes to take a more active approach against the increased risk of stroke in snorers.

Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population

“…Snoring could cause anoxemia, leading to oxidative stress responses and endothelial dysfunction, 41 all of which might lead to atherosclerosis and contribute to incident stroke. 42 In addition, a high-level vibration transmitted to the carotid artery caused by snoring might trigger a cascade effect on the numerous cells of the arterial wall and lead to injury to the vessel and rupture of plaque. 42 …”

“… 42 In addition, a high-level vibration transmitted to the carotid artery caused by snoring might trigger a cascade effect on the numerous cells of the arterial wall and lead to injury to the vessel and rupture of plaque. 42 …”

Multidimensional Sleep Health Is Associated with Cardiovascular Disease Prevalence and Cardiometabolic Health in US Adults

“…There is convincing evidence that sleep apnea is related to obesity, T2D, and HTN etiology [ 1 , 30 , 33 ]. Further, snoring has been linked to poorer cardiovascular health and higher cardiometabolic risk scores that encompass BMI, BP, and fasting glucose [ 34 , 35 ], and in a meta-analysis to 46% higher risk of incident stroke [ 36 ]. Difficulty falling asleep (an insomnia complaint) was also consistently related to all study outcomes and has been extensively linked to cardiometabolic risk factors [ 1 ].…”

Genetic insights into the risk of snoring on stroke and ischemic stroke: A single-variable and multivariable Mendelian randomization

“…Therefore, these findings about the association between stroke risk and snoring could not be verified whether habitual snoring was associated with stroke risk and required further research. Recently, a result of a meta-analysis including 3,598 stroke patients and 145,901 participants without stroke, suggested that snoring was associated with a significantly increased risk of stroke (relative risk 1.46; 95% CI, 1.29–1.63; P < 0.001) ( 31 ). A similar meta-analysis conducted by Min Li et al reported that snoring had a modest but statistically significant positive association with the risk of stroke ( 32 ).…”