Genetic insights into the risk of snoring on stroke and ischemic stroke: A single-variable and multivariable Mendelian randomization

Abstract

BackgroundMultiple risk factors of stroke have been identified in previous studies; however, the causal role of snoring in the onset of stroke is less investigated. To clarify the causal association of snoring on stroke and its subtypes, this study is performed.MethodsThe single nucleotide polymorphisms in relation to snoring were retrieved from the UK biobank cohort with 408,317 participants. The data for stroke and its subtypes of European ancestry (67,162 cases and 453,702 controls) were obtained from the MEGASTROKE consortium. In single-variable Mendelian randomization (SVMR) and multivariable MR (MVMR) analyses, inverse variance weighting was used as the primary estimate, complemented with sensitivity analyses more robust to pleiotropy.ResultsGenetically predicted snoring increased the risk of stroke (odds ratio [OR] = 2.69, 95% confidence interval [CI] = 1.19–6.08, P = 0.016) and ischemic stroke (IS) (OR = 2.82, 95% CI = 1.23–6.44, P = 0.013), but not large artery stroke (LAS) (OR = 3.02, 95% CI = 0.31–29.44, P = 0.339), cardioembolic stroke (CES) (OR = 1.51, 95% CI = 0.58–3.92, P = 0.395). We provide novel genetic evidence that snoring increases the risk of stroke and IS, but not LAS, CES, and SVS.ConclusionOur findings provide novel genetic evidence that snoring increases the risk of stroke and IS, but not LAS, CES, and SVS.

Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population

“…Two previous two-sample MR studies were performed among the Europeans, while the results were inconsistent, probably influenced by the difference in the sample sizes of the discovery population of snoring GWAS. 37 , 38 The latest study, performed based on a recent meta-analysis of the GWAS of snoring (172,050 snoring cases and 350,316 controls), whose sample size was larger than another study, didn't observe an association between snoring and stroke, both in UVMR (OR [95% CI] = 1.06 [0.84–1.34]) and MVMR with adjusting for BMI (1.03 [0.77–1.37]). 37 The ethnic difference might contribute to the difference between the present and previous studies.…”

Causal association between circulating inflammatory cytokines and intracranial aneurysm and subarachnoid hemorrhage

“…The MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) approach was employed to identify significant SNPs explaining possible pleiotropy [23], and outlier SNPs were subsequently removed. F statistics = (Beta/Se) 2 results, indicating the strength of MR, were assessed, and SNPs with an F statistics value below 10, suggesting insufficient strength [24,25], were pruned. In this formula, beta is the correlation coefficient between SNPs and traits, SE represents standard error.…”

Recent advances in mechanistic, therapeutic, and diagnostic research of cerebrovascular diseases: updates from brain & BrainPET 2022

“…Among other findings, they confirmed that genetically predicted metabolic syndrome, waist circumference, hypertension, and triglycerides are associated with an increased risk of large artery stroke. 15 Their observations highlight the importance of early metabolic syndrome management for stroke prevention.…”