SNOM/AFM microprobe integrated with piezoresistive cantilever beam for multifunctional surface analysis

Grabiec, P.; Gotszalk, Teodor; Radojewski, J.; Edinger, Klaus; Abedinov, N.; Rangelow, Ivo W.

doi:10.1016/s0167-9317(02)00428-8

Cited by 32 publications

(7 citation statements)

References 5 publications

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“…To apply such stimuli locally, multifunctional cantilevers are of great interest. Examples are cantilevered scanning near field optical microscopy probes (38), pipette probes (39) or conductive probes, which are used as electrochemical sensors for instrumentation for scanning electrochemical microscopy (SECM).…”

Section: Instrumentation For Scanning Electrochemical Microscopymentioning

confidence: 99%

Atomic Force Microscopy of Biological Membranes

Frederix

Bosshart

Engel

2009

Biophysical Journal

115

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Atomic force microscopy (AFM) is an ideal method to study the surface topography of biological membranes. It allows membranes that are adsorbed to flat solid supports to be raster-scanned in physiological solutions with an atomically sharp tip. Therefore, AFM is capable of observing biological molecular machines at work. In addition, the tip can be tethered to the end of a single membrane protein, and forces acting on the tip upon its retraction indicate barriers that occur during the process of protein unfolding. Here we discuss the fundamental limitations of AFM determined by the properties of cantilevers, present aspects of sample preparation, and review results achieved on reconstituted and native biological membranes.

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Section: Instrumentation For Scanning Electrochemical Microscopymentioning

confidence: 99%

Atomic Force Microscopy of Biological Membranes

Frederix

Bosshart

Engel

2009

Biophysical Journal

115

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“…Light guiding and transmission of subwavelength diameter channels in metal has been a subject of research for years [7,8]. Several methods to counter this limitation were proposed, such as large cone angle probes [9][10][11], asymmetrically structured probes [12], triple tapered probes [13,14] or cantilever probes [15,16]. Large cone angle probes increase transmission by up to two orders of magnitude by virtue of shortening the distance for which evanescent solutions exist.…”

Section: Introductionmentioning

confidence: 99%

Corrugated SNOM probe with enhanced energy throughput

Antosiewicz

Szoplik

2008

Opto-Electronics Review

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In a previous paper we proposed a modification of metal-coated tapered-fibre aperture probes for scanning near-field optical microscopes (SNOMs). The modification consists in radial corrugations of the metal-dielectric interface oriented inward the core. Their purpose is to facilitate the excitation of surface plasmons, which increase the transport of energy beyond the cut-off diameter and radiate a quasi-dipolar field from the probe output rim. An increase in energy output allows for reduction of the apex diameter, which is the main factor determining the resolution of the microscope. In two-dimensional finite-difference time-domain (FDTD) simulations we analyse the performance of the new type of SNOM probe. We admit, however, that the two-dimensional approximation gives better results than expected from exact three-dimensional ones. Nevertheless, optimisation of enhanced energy throughput in corrugated probes should lead to at least twice better resolution with the same sensitivity of detectors available nowadays.

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“…The change in the resistivity can be most conveniently measured by using a Wheatstone bridge. Piezoresistive microcantilevers are ideal for detecting the changes in surface stress due to cantilever deflection upon binding of biochemical agents; they do not require external detection devices, they do not require tedious alignment, and they can be made to fit in an integrated electromechanical system [7].…”

Section: Introductionmentioning

confidence: 99%

High sensitivity piezoresistive cantilever design and optimization for analyte-receptor binding

Yang

Zhang

Vafai

et al. 2003

J. Micromech. Microeng.

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The mechanical design and optimization of piezoresistive cantilevers for biosensing applications is studied using finite element analysis. The change of relative resistivity of piezoresistive microcantilevers is analyzed in the presence of the chemical reaction at the receptor surface under the condition of oscillating flow. Chemo-mechanical binding forces have been analyzed in order to understand issues of saturation over the cantilever surface. Furthermore, the optimum design using finite element modeling is achieved by modifying the factors pertaining to the geometry of the microcantilevers under the condition of bio-binding. The introduction of stress concentration regions (SCRs) during cantilever fabrication has been discussed, which greatly enhances the detection sensitivity through increased surface stress. Finally, the optimum SCR modified ‘C’ piezocantilever system for biosensing is designed and the optimal parameters are set for high sensitivity.

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SNOM/AFM microprobe integrated with piezoresistive cantilever beam for multifunctional surface analysis

Cited by 32 publications

References 5 publications

Atomic Force Microscopy of Biological Membranes

Atomic Force Microscopy of Biological Membranes

Corrugated SNOM probe with enhanced energy throughput

High sensitivity piezoresistive cantilever design and optimization for analyte-receptor binding

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