Snedds as Lipid-Based Nanocarrier Systems: Concepts and Formulation Insights

GOTTEMUKKULA, LAKSHMI DEVI; Sampathi, Sunitha

doi:10.22159/ijap.2022v14i2.42930

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…According to [12] the pH meets the requirements of the SNEDDS preparation, namely pH 1.2-7.4. pH measurements were carried out using a pH meter with electrodes calibrated with standard buffers of pH 4 and pH 7 [21,22].…”

Section: Physical Evaluation Of Preparations Ph Testmentioning

confidence: 99%

Formulation and Characterization of Self Nano-Emulsifying Drug Delivery System (Snedds) Fraction of N-Hexane: Ethyl Acetate From Sesewanua Leaf (Clerodendrum Fragrans Wild.)

Sapiun

Imran

DEWI³

et al. 2023

Int J App Pharm

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Objective: Sesewanua leaves contain alkaloid compounds as antioxidants, and its leaves can be used to formulate SNEDDS dosage forms, which can effectively deliver the medicine. This study intended to determine the variation of surfactant concentration (Tween 80) and cosurfactant (PEG 400) towards pH, viscosity, nano-emulsion duration and characterization using PSA method (particle size and polydispersity index). Methods: This study employed a quasi-experimental method and the independent variables in this study were variations in the concentration of surfactant (Tween 80) and cosurfactant (PEG 400), which consist of 3 formulas, such as SFS 1 (6:3), SFS 2 (7:2), and SFS 3 (8:1). The dependent variables in this study including pH, viscosity, nano-emulsion time, particle size and polydispersity index which utilized One Way Anova Post Hoc LSD (p>0.05) and Tamhane (p<0.05) tests as the data analysis. Results: The pH test SFS1-SFS3 has a pH value of 7.92, 8.30 and 8.35, followed by Viscosity test SFS1-SFS3, which has a viscosity value of 1.00 cP, 1.38 cP and 2.91 cP. Further, the SFS1-SFS3 nano emulsified time test had nano emulsified time in gastric and intestinal fluids 35.18s and 43.96s, 43.54s and 47.13s and 44.00s and 50.29s. Characterization of SFS1-SFS3 particle size in gastric and intestinal fluids 23.9 nm and 23.0 nm, 18.5 nm and 22.7 nm and 19.1 nm and 22.9 nm, while characterization of SFS1-SFS3 polydispersity index in gastric and intestinal fluids were 0.433 and 0.348, 0.451 and 0.440 and 0.568 and 0.462. Conclusion: The increase of variations in surfactant concentration and decreased cosurfactant significantly affected pH, viscosity, nano-emulsion time, and particle size of SFS preparations. However, the polydispersity index was not considerably affected.

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Section: Physical Evaluation Of Preparations Ph Testmentioning

confidence: 99%

Formulation and Characterization of Self Nano-Emulsifying Drug Delivery System (Snedds) Fraction of N-Hexane: Ethyl Acetate From Sesewanua Leaf (Clerodendrum Fragrans Wild.)

Sapiun

Imran

DEWI³

et al. 2023

Int J App Pharm

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“…In the area of formulation development, the Design of Experiment method has seen significant growth in popularity during the past several years [7]. In the present study, we have chosen the self-nanoemulsifying drug delivery system (SNEDDS) as the preferred method for delivering the proposed combination therapy of ibrutinib and quercetin.…”

Section: Introductionmentioning

confidence: 99%

Fixed Dose Combination Therapy of Ibrutinib and Quercetin by Snedds-Development and Evaluation by Design of Experiment

BAGRI,

NAGARAJU

2023

Int J App Pharm

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Objective: Self-nano emulsifying drug delivery system (SNEDDS) comprising quercetin and ibrutinib as a fixed dosage combination therapy is being investigated to increase drug solubility and dissolution rate. Methods: On the basis of preliminary solubility tests, castor oil, Kolliphor® RH 40, and PEG600 were utilised to construct ternary phase diagrams. The effect of the amount of Castor oil (A), Kolliphor® RH 40 (B), and PEG600 (C) on the particle size and encapsulation efficiency of ibrutinib and quercetin was evaluated and statistically analysed using multiple regression in 17 trials planned using a 33 Box-Behnken design. FTIR, XRD, DSC, SEM, and stability experiments were employed to characterise the optimised formulation. The particle size, zeta potential, polydispersity index, encapsulation efficiency, and in vitro drug release of ibrutinib and quercetin were also investigated. Results: Ibrutinib and quercetin had encapsulation efficiencies of 61.56-87.22% (Y3) and 60.12-87.12%, respectively, according to the size range of SNEDDS formulations (1-17) of 70.18-200.56 nm. The optimised SNEDDS formulations (S1–S3) showed a particle size range of 71.12–76.38 nm, PDI of 0.126–0.312, zetapotential of-24.6–28.4, and encapsulation efficiencies of 88.98–90.22% and 84.96–86.78% for ibrutinib and quercetin, respectively. According to in vitro testing, the medication released from SNEDDS was released more quickly (>90% 600 min). The formulation was further evaluated using FTIR, XRD, DSC, SEM, and stability investigations, which validated the complexation of ibrutinib and quercetin in the drug's amorphous state and stability for six months. Conclusion: This study revealed that SNEDDS could be used as a drug carrier for ibrutinib and quercetin due to their improved solubility and dissolution rate.

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“…Lipid-based drug delivery systems (LBDDS) have recently become very popular because of their remarkable ability to deliver drugs with poor absorption using lipids as carriers [10]. LBDDS are broadly classified as emulsion, vesicular system, and particulate lipid systems [11].…”

Section: Introductionmentioning

confidence: 99%

Development of Cathelicidin in Liposome Carrier Using Thin Layer Hydration Method

et al. 2022

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Objective: The purpose of this study was to produce an optimum liposome formulation and to study the effect of formulation parameter such as phospholipid amount and hydration time on characteristics of liposome containing Cathelichidin. Methods: Liposomes were prepared using a thin layer hydration method. Characterization of liposomes included organoleptic, PSA (Particle Size Analyzer) and zeta potential, entrapment efficiency, morphology by TEM (Transmission Electron Microscopy), the chemical interaction by FTIR (Fourier Transform Infrared Spectroscopy), and the stability by using Freeze-Thaw method. Results: The result of the organoleptic test showed that the liposome were in the form of milky white dispersion, odorless, and without sedimentation. Optimum formula was obtained by making variations of soy oil: cholesterol 10: 0 (F1), 9: 1 (F2), 8: 2 (F3), 7: 3 (F4), and variations in sonication time (10 and 30 min). Based on the results, it was found that the optimum sonication time was 30 min. F2 and F3 were chosen as the most optimum formulas with particle sizes of 190.3±6.8 nm and 212.9±4.4 nm; polydispersity index of 0.192±0.023 and 0.137±0.022, and zeta potential as much as-38.8±0.6 mV and-34.8±2.0 mV. To the optimum formula, cathelicidin was loaded with hydration time varies of 100 and 120 min. Longer hydration time resulted in smaller particle size and higher entrapment efficiency either for F2 or F3. TEM characterization revealed a spherical shape of liposomes from the optimum formula. The results of FTIR characterization did not show any interaction between the phospholipids of liposomes with cathelicidin. The data from the stability test showed good stability for F2 and F3 with a hydration time of 120 min, indicated by a p-value>0.05, which indicated that there was no significant change in the zeta potential for three Freeze-Thaw cycles. Conclusion: Formula of liposom using a variation of soy oil: cholesterol 9:1 and 8:2 with hydration time of 120 min revealed the best result with good stability for three Freeze-Thaw cycles.

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Snedds as Lipid-Based Nanocarrier Systems: Concepts and Formulation Insights

Cited by 6 publications

References 45 publications

Formulation and Characterization of Self Nano-Emulsifying Drug Delivery System (Snedds) Fraction of N-Hexane: Ethyl Acetate From Sesewanua Leaf (Clerodendrum Fragrans Wild.)

Formulation and Characterization of Self Nano-Emulsifying Drug Delivery System (Snedds) Fraction of N-Hexane: Ethyl Acetate From Sesewanua Leaf (Clerodendrum Fragrans Wild.)

Fixed Dose Combination Therapy of Ibrutinib and Quercetin by Snedds-Development and Evaluation by Design of Experiment

Development of Cathelicidin in Liposome Carrier Using Thin Layer Hydration Method

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