Sn-Triggered Two-Dimensional Fast Protein Assembly with Emergent Functions

Saif, Bassam; Zhang, Wenxin; Zhang, Xu; Gu, Quan; Yang, Peng

doi:10.1021/acsnano.9b01392

Cited by 30 publications

(33 citation statements)

References 97 publications

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“…In recent years, protein‐based 2D assemblies have attracted attention, as many functional 2D protein crystals, such as bacterial S‐layer protein/crystal [ 33,34 ] and purple‐membrane assemblies, [ 55 ] have been found in nature. In the field of protein engineering, researchers have fabricated 2D free‐standing protein architectures by manipulating distinct chemical interactions between protein building blocks [ 11,56 ] and have designed de novo protein structures. [ 57 ] However, there are few reports about building 2D protein crystals at solid–liquid interfaces.…”

Section: Proteinsmentioning

confidence: 99%

Engineering Biomolecular Self‐Assembly at Solid–Liquid Interfaces

et al. 2020

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Biomolecular self‐assembly is a key process used by life to build functional materials from the “bottom up.” In the last few decades, bioengineering and bionanotechnology have borrowed this strategy to design and synthesize numerous biomolecular and hybrid materials with diverse architectures and properties. However, engineering biomolecular self‐assembly at solid–liquid interfaces into predesigned architectures lags the progress made in bulk solution both in practice and theory. Here, recent achievements in programming self‐assembly of peptides, proteins, and peptoids at solid–liquid interfaces are summarized and corresponding applications are described. Recent advances in the physical understandings of self‐assembly pathways obtained using in situ atomic force microscopy are also discussed. These advances will lead to novel strategies for designing biomaterials organized at and interfaced with inorganic surfaces.

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Section: Proteinsmentioning

confidence: 99%

Engineering Biomolecular Self‐Assembly at Solid–Liquid Interfaces

et al. 2020

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“…[109][110][111] In a study conducted by Saif et al, tin ion Sn 2+ was found for the first time to initiate rapid amyloid-like protein assembly by effectively reducing the disulfide bonds of lysozyme, and a multifunctional 2D Sn-doped lysozyme hybrid nanofilm was finally formed at the air/water interface (Figure 9a). [112] The area and thickness of the hybrid nanofilm could be controlled by the air/water interface size and protein concentration or reaction time. The high affinity of cystine residues to Sn 2+ played a crucial role in the coordination, stabilization, and rapid formation of the thermodynamically favored hybrid film.…”

Section: Wwwadvmatinterfacesdementioning

confidence: 99%

“…PTLF-HAp: The key challenge in the bone tissue engineering is to design and construct an interface with excellent bioactivity to support controllable and robust attachment of hydroxyapatite Reproduced with permission. [112] Copyright 2019, American Chemical Society. b) Fabrication of a freestanding protein-bound silver film.…”

confidence: 99%

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Amyloid‐Mediated Fabrication of Organic–Inorganic Hybrid Materials and Their Biomedical Applications

Zhao

Yang

2020

Adv Materials Inter

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nanostructures can be organized into a hierarchical architecture, thus giving their excellent physical and chemical properties. [1,6,7] Accordingly, protein-based biomimetic mineralization has been became an inspiration for synthesis of the highperformance organic-inorganic hybrid materials. Recently, many reviews have been published to report the progress of biomimetic organic-inorganic nanocomposites. Wang et al. reviewed the preparation of layered organic-inorganic nanocomposites inspired by nacre and indicated the advantages and disadvantages of various biomimetic strategies. [8] Zhang et al. summarized recent research on graphene-based artificial nacre nanocomposites and focused on the interface interactions design. [9] Wang et al. discussed functional protein-based organic-inorganic hybrid nanomaterials with an emphasis on the novel preparation methods, resulting nanostructures, and their potential applications in drug delivery and enzymatic catalysis. [10] Yao et al. summarized the fabrication of artificial layered structural nanocomposites based on the different inorganic building blocks, such as clays, ceramic nanoparticles, layered double hydroxides, calcium carbonate, and graphene. [11] Zhao et al. overviewed the synthesis and performance enhancement strategies for different dimensional nacre-inspired materials such as 1D fibers, 2D films, and 3D bulk composites. [6] The reviews mentioned above are mainly focused on the strategies to construct layered organic-inorganic hybrid materials and their applications in various fields, and the interface design to obtain high-performance structural nanocomposites. Although it has been demonstrated that the protein components function as templates involving in the biomineralization, the regulation on their structure and the mediation of proteins on the fabrication of hybrid materials are seldom presented, mainly because of their complex molecular structure and uncontrollable selfassembly process in vitro. Amyloid is a kind of insoluble self-assembly peptide or protein aggregate displaying polymorphic mesoscopic structures. [12] Even though the amyloids are originally discovered as the pathological hallmarks of human neurodegenerative diseases, it is found that there are also many nonpathogenic functional amyloid aggregates implicated in biological processes occurring in a variety of organisms ranging from simple bacteria to humans, such as the adhesive property of E. coil biofilms, [13] biosynthesis Protein assembly with ordered architecture plays an important role in the formation of natural organic-inorganic hybrid materials, and also determines their distinguished mechanical, optical, and biochemical properties. Nevertheless, it has been a huge challenge to synthesize materials with hierarchical structure accurately mimicking the natural hybrid materials in vitro. In the past decade, protein amyloid aggregates, due to their diverse and controllable nanostructures and unique properties, have been developed as superior templates or building blocks to fabricate f...

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“…Firstly, unlike self-assembled biopolymer structures in nature, the fabrication of a macroscopic 2D biopolymer material through economic supramolecular assembly remains a challenge, let alone the integration with AIEgens. [2][3][4][5]11,12 Secondly, the lack of a method to chemically or physically encode AIEgens into a 2D array of biopolymer chains further constrains the development of AIEgen@2D biopolymer materials. [1][2][3]13 Herein, we report sensitive binding of AIEgens to newlydeveloped amyloid-like suprastructures, which present the promising capability to synthesize highly emissive fluorescent 2D proteinaceous nanofilms, coatings and water-based inks.…”

Section: Introductionmentioning

confidence: 99%