Sn<sup>4+</sup> complexation with sulfonated-carbon dots in pursuit of enhanced fluorescence and singlet oxygen quantum yield

Luo, Qiang; Ding, Haizhen; Hu, Xiaolong; Xu, Jiahui; Sadat, Anwar; Xu, Mingsheng; Primo, Fernando Lucas; Tedesco, Antônio Cláudio; Zhang, Haiyuan; Hong, Bo

doi:10.1039/d0dt01187h

Cited by 16 publications

(7 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results demonstrate that R-CDs have a longer lifetime to interact with oxygen molecules when compared with that of MB, thus a high yield of 1 O 2 production was obtained. The singlet oxygen yield of 0.91 obtained in this work is also the highest among the CDs reported so far (Figure G). − …”

Section: Results and Discussionsupporting

confidence: 60%

Phosphate-Assisted Transformation of Methylene Blue to Red-Emissive Carbon Dots with Enhanced Singlet Oxygen Generation for Photodynamic Therapy

Wang

Ran

et al. 2021

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Photodynamic therapy (PDT) has attracted wide attention due to its distinct advantages in cancer treatment. Herein, a kind of red emissive carbon dots (R-CDs) was synthesized from methylene blue (MB) and phosphate through a hydrothermal method. The resultant R-CDs display good biocompatibility, photostability, and high singlet oxygen ( 1 O 2 ) yield (0.91); thus, they have been successfully applied to the PDT study in vitro. More importantly, the R-CDs show noninfective property to DNA, which is substantially different to their precursor MB. The structure of R-CDs was comprehensively characterized both experimentally as well as by density functional theory (DFT) calculations. This study not only provides a rational strategy for preparation of highly efficient PDT material but also gives insight into the mechanism of 1 O 2 generation.

show abstract

Section: Results and Discussionsupporting

confidence: 60%

Phosphate-Assisted Transformation of Methylene Blue to Red-Emissive Carbon Dots with Enhanced Singlet Oxygen Generation for Photodynamic Therapy

Wang

Ran

et al. 2021

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

“…This is because Mn-unsaturated Mn-N5 coordination provides an active site. In Table , we have sorted various non-single-atom anchored metal-doped CDs used in PDT. − The present work used post-modification strategies to prepare Mn-doped CDs. Unlike previously reported Mn-doped CDs (Mn-CDs), which are made using Mn-containing molecules as precursors, this assures that Mn is attached to the surface.…”

Section: Resultsmentioning

confidence: 99%

Single-Atom Manganese Anchored on Carbon Dots for Promoting Mitochondrial Targeting and Photodynamic Effect in Cancer Treatment

Wang

Liang

et al. 2022

ACS Appl. Nano Mater.

Self Cite

View full text Add to dashboard Cite

The sustained rapid growth of tumor cells depends directly on the activity of mitochondria, which are important targets for many cancer drugs. Here, we report on a self-targeting method for mitochondria, a high atom efficiency nanoplatform, Mn/HA-CDs, made from hyaluronic acid-derived carbon dots (HA-CDs) and Mn2+ in a coordination structure of Mn-N5. We found that the Mn/HA-CDs with atomically dispersed Mn (0.73%) can generate reactive oxygen species (ROS) with a high atom economy. Particularly, its singlet oxygen (1O2) quantum yield (0.40) is 3 times higher than that of the previous HA-CDs (0.13). Active absorption of Mn/HA-CDs by mitochondria inhibits mitochondrial superoxide dismutase (SOD) enzyme function, intensifies ROS damage to the mitochondria, and eventually promotes the photodynamic therapy (PDT) effect on tumor cells. Our findings suggest that targeting mitochondria with single-atom metal-anchored CDs for a better PDT effect is a viable method of treating tumors.

show abstract

“…Finally, the obtained Cu‐CDs were successfully employed as HepG2 cell imaging agents. In the study of Luo and co‐workers, the authors reported stannum‐doped CDs (Sn‐CDs) by complexing Sn 4+ with sulfonated‐CDs (S‐CDs) under ultra‐sonication, which was also used for HepG2 cells imaging [76] . Most of the metal ions would quench the fluorescence of S‐CDs, while Sn 4+ enhanced the emission of S‐CDs with a quantum yield of 32 %.…”

Section: M‐cds For Versatile Bio‐applicationsmentioning

confidence: 99%

Emerging and Versatile Platforms of Metal‐Ion‐Doped Carbon Dots for Biosensing, Bioimaging, and Disease Therapy

Qian

et al. 2022

ChemMedChem

View full text Add to dashboard Cite

Metal ions possess abundant electrons and unoccupied orbitals, as well as large atomic radii, whose doping into carbon dots (CDs) is a facile strategy to endow CDs with additional physicochemical characteristics. After being doped with metal ions, CDs reveal obvious changes in their optical, electronic, and magnetic properties by adjustments to their electron density distribution and the energy gaps, leading them to be promising and competitive candidates as labeling probes, imaging agents, catalysts, nanodrugs, and so on. In this review, we summarize the fabrication methods of metal‐ion‐doped CDs (M‐CDs), and highlight their biological applications including biosensing, bioimaging, tumor therapy, and anti‐microbial treatment. Finally, the challenging future perspectives of M‐CDs are analyzed. We hope this review will provide inspiration for further development of M‐CDs in various biological aspects, and help readers who are interested in M‐CDs and their biological applications.

show abstract

Sn⁴⁺ complexation with sulfonated-carbon dots in pursuit of enhanced fluorescence and singlet oxygen quantum yield

Abstract: Cross-linking sulfonated carbon dots with Sn4+ can greatly enhance the fluorescence and lead to a higher singlet oxygen quantum yield.

Cited by 16 publications

References 42 publications

Phosphate-Assisted Transformation of Methylene Blue to Red-Emissive Carbon Dots with Enhanced Singlet Oxygen Generation for Photodynamic Therapy

Phosphate-Assisted Transformation of Methylene Blue to Red-Emissive Carbon Dots with Enhanced Singlet Oxygen Generation for Photodynamic Therapy

Single-Atom Manganese Anchored on Carbon Dots for Promoting Mitochondrial Targeting and Photodynamic Effect in Cancer Treatment

Emerging and Versatile Platforms of Metal‐Ion‐Doped Carbon Dots for Biosensing, Bioimaging, and Disease Therapy

Contact Info

Product

Resources

About

Sn4+ complexation with sulfonated-carbon dots in pursuit of enhanced fluorescence and singlet oxygen quantum yield

Abstract: Cross-linking sulfonated carbon dots with Sn4+ can greatly enhance the fluorescence and lead to a higher singlet oxygen quantum yield.

Cited by 16 publications

References 42 publications

Phosphate-Assisted Transformation of Methylene Blue to Red-Emissive Carbon Dots with Enhanced Singlet Oxygen Generation for Photodynamic Therapy

Phosphate-Assisted Transformation of Methylene Blue to Red-Emissive Carbon Dots with Enhanced Singlet Oxygen Generation for Photodynamic Therapy

Single-Atom Manganese Anchored on Carbon Dots for Promoting Mitochondrial Targeting and Photodynamic Effect in Cancer Treatment

Emerging and Versatile Platforms of Metal‐Ion‐Doped Carbon Dots for Biosensing, Bioimaging, and Disease Therapy

Contact Info

Product

Resources

About

Sn⁴⁺ complexation with sulfonated-carbon dots in pursuit of enhanced fluorescence and singlet oxygen quantum yield