Sn(IV) porphyrin-biotin decorated nitrogen doped graphene quantum dots nanohybrids for photodynamic therapy

Magaela, N. Bridged; Matshitse, Refilwe; Babu, Balaji; Manga, Muthumuni; Prinsloo, Earl; Nyokong, Tebello

doi:10.1016/j.poly.2021.115624

Cited by 21 publications

(11 citation statements)

References 52 publications

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“…All of the compounds exhibited cell viability over 90% for dark toxicity, but 2-B-NGQDs exhibited particularly significant PDT activity at a dose of 40 g/mL, with cell viability of just 22%. This study results compared to pure complex-2, we find that the biotin-decorated, nitrogen-doped graphene quantum dots with porphyrin complex-2 actually boosts its PDT activity efficiently [117]. antitumor activity compared to free porphyrins [119].…”

Section: The Third Generation Photosensitizersmentioning

confidence: 71%

Recent Developments of Porphyrin Photosensitizers in Photodynamic Therapy

Alibasha¹,

Ghosh²

2023

Preprint

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In the modern era, chemotherapy, radiation therapy, biomarker testing, immunotherapy, sonodynamic therapy, hormone therapy, photothermal therapy, photodynamic therapy, and many more therapies are available for cancer. Photodynamic therapy (PDT) is a potential, innovative and non-invasive way of treating cancer. The main component of PDT is photosensitizers (PS), role in the practical applications of PDT. When these PS are exposed to appropriate light or laser irradiation, they absorb the energy and enter an excited state. They eventually transmit the energy to the neighbouring molecules, generating reactive oxygen species (ROS), especially singlet oxygen (1O2) into the model animals and patients. The most used and popular sensitizers, such as photofrin, hematoporphyrin (Hp), aminolevulinic acid (ALA), Porphyrin, and its derivatives, were developed regularly from first-generation to third-generation PS. After the second-generation PS highly focused on Porphyrin and its derivatives with modification and complexation to boost the efficiency of PDT against cancer cells. This review focuses on the PDT development of porphyrins with nanoparticles as third-generation PS with selectivity, toxicity and biocompatibility. In addition, porphyrin-based nanomedicines are discussed in terms of current challenges and future prospects.

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Section: The Third Generation Photosensitizersmentioning

confidence: 71%

Recent Developments of Porphyrin Photosensitizers in Photodynamic Therapy

Alibasha¹,

Ghosh²

2023

Preprint

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“…Studies showed that SnPp-B-NGQDs had greater cellular uptake, which correlates with its PDT activity against MCF-7 cells. SnPp-B-NGQDs showed high phototoxicity with an IC 50 value of 10.4 μg mL −1 compared to SnPp alone with an IC 50 value of 11.2 μg mL −1 , which implies that the biotin-decorated nitrogen-doped graphene quantum enhanced the activity of SnPp 192 (Fig. 8b and c).…”

Section: Applications Of Gqd-pp/pc Conjugatesmentioning

confidence: 94%

“…15,27,43,163,191 In the study by Magaela et al , propanoic acid was heated to 120 °C and refluxed with 2-(4-morpholinyl) benzaldehyde in the presence of 4-(4-morpholinyl) benzaldehyde. The mixture was then added to pyrrole and refluxed, and cooled to precipitate the porphyrin, giving a yield of 78% 192 (Scheme 2a). Santos et al employed two distinct synthetic approaches to covalently functionalize GQDs with aminoporphyrin 1 .…”

Section: Construction Of Gqd-porphyrin/phthalocyanine Hybrid Systemsmentioning

confidence: 99%

Graphene quantum dot-porphyrin/phthalocyanine multifunctional hybrid systems: from interfacial dialogue to application

et al. 2022

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“…17). 98 Biotin is a cancer cell targeting moiety as its receptors are overexpressed in cancer cells. Biotin and Sn(IV)-porphyrin (11) are linked to nitrogen-doped graphene quantum dots (NGQDs) through amide linkages and axial ligation, as shown in Fig.…”

Section: Use Of Biomolecules and Nanoparticles To Enhance Aqueous Sol...mentioning

confidence: 99%