Smooth pursuit and saccadic abnormalities in first-episode schizophrenia

Hutton, Samuel B.; Crawford, Trevor J.; Puri, Basant K.; Duncan, L.-J.; Chapman, M. John; Kennard, Christopher; Barnes, Thomas R. E.; Joyce, Eileen M.

doi:10.1017/s0033291798006722

Cited by 105 publications

(75 citation statements)

References 49 publications

(57 reference statements)

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“…The main limitation to the study is the lack of imaging data on control subjects, which makes it impossible to confirm whether oculomotor neuronal circuits are abnormal in schizophrenia. The full significance of the correlations reported in this study may become apparent in planned longitudinal studies with appropriate control subjects, which should also explore other eye movements known to be abnormal in schizophrenia, such as antisaccade latency and increased anticipatory saccades during pursuit (Hutton et al 1998;Tregellas et al 2004).…”

Section: Discussionmentioning

confidence: 85%

“…Schizophrenia has been associated with abnormalities of smooth pursuit (Levy et al 1994) and more recently increased antisaccadic errors, which are erroneous reflexive saccades made towards a peripheral target when subjects are instructed to direct their gaze to its mirror image location (Crawford et al 1995;Fukushima et al 1990;Katsanis et al 1997;McDowell & Clementz, 1997). Both abnormal smooth pursuit and increased antisaccade errors have been found at illness onset in medication-naïve patients (Sweeney at al, 1992;Lieberman et al 1993;Hutton et al 1998) and in first-degree relatives (Holzman et al 1988;Crawford et al 1998;Ross et al 1998). Thus, oculomotor abnormalities may represent markers of genetic vulnerability to schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

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Structural neural networks subserving oculomotor function in first-episode schizophrenia

Bagary

Hutton

Symms

et al. 2004

Biological Psychiatry

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Structural neural networks subserving oculomotor function in first-episode schizophrenia

Bagary

Hutton

Symms

et al. 2004

Biological Psychiatry

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“…Several studies have demonstrated increased antisaccade errors in populations with known working memory limitations. For example antisaccade errors and correct antisaccade latencies are increased in patients with schizophrenia (Hutton et al, 1998;, and the degree of impairment correlates significantly with working memory dysfunction in these patients (Hutton et al, 2004). Similarly, increased antisaccade errors reported in healthy elderly participants (e.g.…”

Section: Discussionmentioning

confidence: 90%

The antisaccade task as an index of sustained goal activation in working memory: modulation by nicotine

2006

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Article (Unspecified) http://sro.sussex.ac.uk Rycroft, Nicola, Hutton, Samuel B. and Rusted, Jennifer M. (2006) The antisaccade task as an index of sustained goal activation in working memory: modulation by nicotine. Psychopharmacology, 188 (4). pp. [521][522][523][524][525][526][527][528][529] This version is available from Sussex Research Online: http://sro.sussex.ac.uk/738/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. Recent models of antisaccade performance suggest that errors are more likely to occur when the intention to initiate an antisaccade is insufficiently activated within working memory. Nicotine has been shown to enhance specific working memory processes in healthy adults. We explored the effect of nicotine on antisaccade performance in a large sample (N=44) of young adult smokers. Minimally abstinent participants attended two test sessions and were asked to smoke one of their own cigarettes between baseline and retest during one session only.Nicotine reduced antisaccade errors and correct antisaccade latencies if delivered before optimum performance levels are achieved, suggesting that nicotine supports the activation of intentions in working memory during task performance. The implications of this research for current theoretical accounts of antisaccade performance, and for interpreting the increased rate of antisaccade errors found in some psychiatric patient groups are discussed.

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“…Patients followed longitudinally show a persistent elevation in antisaccade error rates over time, suggesting an enduring deficit of prefrontal functioning (14,15,16).…”

Section: Introductionmentioning

confidence: 99%

Reduced Attentional Engagement Contributes to Deficits in Prefrontal Inhibitory Control in Schizophrenia

Reilly

Harris

Khine

et al. 2008

Biological Psychiatry

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BACKGROUND-Problems with the voluntary control of behavior, such as those leading to increased antisaccade errors, are accepted as evidence of prefrontal dysfunction in schizophrenia. We previously reported that speeded prosaccade responses, i.e. shorter response latencies for automatic shifts of attention to visual targets, were associated with higher antisaccade error rates in schizophrenia. This suggests that dysregulation of automatic attentional processes may contribute to disturbances in prefrontally-mediated control of voluntary behavior.

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Smooth pursuit and saccadic abnormalities in first-episode schizophrenia

Cited by 105 publications

References 49 publications

Structural neural networks subserving oculomotor function in first-episode schizophrenia

Structural neural networks subserving oculomotor function in first-episode schizophrenia

The antisaccade task as an index of sustained goal activation in working memory: modulation by nicotine

Reduced Attentional Engagement Contributes to Deficits in Prefrontal Inhibitory Control in Schizophrenia

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