Structural neural networks subserving oculomotor function in first-episode schizophrenia

Bagary, M.; Hutton, Samuel B.; Symms, Mark R.; Barker, Gareth J.; Mutsatsa, Stanley; Barnes, Thomas R. E.; Joyce, Eileen M.; Ron, María A.

doi:10.1016/j.biopsych.2004.08.017

Cited by 18 publications

(14 citation statements)

References 79 publications

(84 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Thompson et al, 2005) Moreover, antisaccade performance is highly correlated with the volume of right dorsal frontal lobe structures (including the FEF) in schizophrenia (Bagary et al, 2004;Ettinger et al, 2004), and measurements of cortical thickness reveal that the region surrounding the FEF is severely atrophied in schizophrenics (Cannon et al, 2002). Consistent with our inability to detect a correlation between basal ganglia damage and antisaccade performance in our FTLD subjects, patients with Parkinson's disease do not have measurable antisaccade abnormalities unless they also have dementia caused by extensive cortical pathology (Mosimann et al, 2005).…”

Section: Relationship Between Oculomotor Deficit-correlated Regions Osupporting

confidence: 79%

Medial Versus Lateral Frontal Lobe Contributions to Voluntary Saccade Control as Revealed by the Study of Patients with Frontal Lobe Degeneration

Boxer

Garbutt

Rankin

et al. 2006

Journal of Neuroscience

View full text Add to dashboard Cite

Deficits in the ability to suppress automatic behaviors lead to impaired decision making, aberrant motor behavior, and impaired social function in humans with frontal lobe neurodegeneration. We have studied patients with different patterns of frontal lobe dysfunction resulting from frontotemporal lobar degeneration or Alzheimer's disease, investigating their ability to perform visually guided saccades and smooth pursuit eye movements and to suppress visually guided saccades on the antisaccade task. Patients with clinical syndromes associated with dorsal frontal lobe damage had normal visually guided saccades but were impaired relative to other patients and control subjects in smooth pursuit eye movements and on the antisaccade task

show abstract

Section: Relationship Between Oculomotor Deficit-correlated Regions Osupporting

confidence: 79%

Medial Versus Lateral Frontal Lobe Contributions to Voluntary Saccade Control as Revealed by the Study of Patients with Frontal Lobe Degeneration

Boxer

Garbutt

Rankin

et al. 2006

Journal of Neuroscience

View full text Add to dashboard Cite

show abstract

“…Jagannathan et al found gray matter deficited in patients with schizophrenia consistently with previous reports, including frontal and temporal lobes and thalamus [61]. Bagary et al found that smooth pursuit abnormalities were associated with reduced magnetization transfer ratio in several regions, predominantly in the right prefrontal cortex [62]. Collin et al discovered schizophrenia patients showing both decreased (e.g.…”

Section: Smri-based Brain Network Application In Schizophreniasupporting

confidence: 64%

A Review: Detecting Alterations of Brain Connectivity in Schizophrenia based on Structural MRI

Li¹

2014

J Psychiatry

View full text Add to dashboard Cite

Schizophrenia is a common psychiatric disease with brain connectivity changed. Nowadays brain network has become an effective tool to detect the abnormal brain connectivity in patients. Compared with studies focused on functional and white matter connectivity, the research of grey matter connectivity is relatively less and should be paid more attention. The primary approach of grey matter connectivity analysis is based on brain network constructed from structural MRI (sMRI). There are several morphometric features such as cortical thickness, volume, and curvature etc. Which could be used for sMRI brain network construction? This review briefly introduced sMRI brain network construction and analysis, presenting the most frequently used morphometric features with their effectiveness in schizophrenia, highlighting the application of sMRI brain network in schizophrenia, and finally estimated its potential value.

show abstract

“…However, it has been reported that smooth pursuit quality (measured by pursuit gain or catch-up saccade rate) is significantly associated with measures of frontal structural integrity (Bagary et al, 2004) and frontal activation in schizophrenic patients (Ross et al, 1995;Hong et al, 2005;Keedy et al, 2006) and unaffected relatives (O'Driscoll et al, 1999). Although the PhysAn group did tend towards poorer pursuit gain, the small number of subjects made these results insignificant here.…”

Section: Discussionmentioning

confidence: 59%

“…Eye movements were monitored using an Eyelink infrared video-based tracking system (SR Research, Mississauga, Canada) and data were analyzed with custom software (Holahan and O'Driscoll, 2005). The dependent measure was peak pursuit gain, a measure previously found to be correlated with frontal activation (O'Driscoll et al, 1999) and frontal structural integrity (Bagary et al, 2004). Pursuit gain was compared across groups with a one-way ANOVA.…”

Section: Psychological and Physiological Measuresmentioning

confidence: 99%

“…We hypothesized that schizotypal individuals would show greater striatal DA responses than control subjects. Finally, because theoretical models have linked DA release with frontal lobe dysfunction in schizophrenia (Davis et al, 1991), smooth pursuit eye movements were measured as an index of frontal lobe function (O'Driscoll et al, 1999;Bagary et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Stress-Induced Dopamine Release in Humans at Risk of Psychosis: a [11C]Raclopride PET Study

Soliman

O’Driscoll

Pruessner

et al. 2007

Neuropsychopharmacol

133

109

View full text Add to dashboard Cite

Drugs that increase dopamine levels in the brain can cause psychotic symptoms in healthy individuals and worsen them in schizophrenic patients. Psychological stress also increases dopamine release and is thought to play a role in susceptibility to psychotic illness. We hypothesized that healthy individuals at elevated risk of developing psychosis would show greater striatal dopamine release than controls in response to stress. Using positron emission tomography and [ 11 C]raclopride, we measured changes in synaptic dopamine concentrations in 10 controls and 16 psychometric schizotypes; 9 with perceptual aberrations (PerAb, ie positive schizotypy) and 7 with physical anhedonia (PhysAn, ie negative schizotypy). [ 11 C]Raclopride binding potential was measured during a psychological stress task and a sensory-motor control. All three groups showed significant increases in self-reported stress and cortisol levels between the stress and control conditions. However, only the PhysAn group showed significant stress-induced dopamine release. Dopamine release in the entire sample was significantly negatively correlated with smooth pursuit gain, an endophenotype linked to frontal lobe function. Our findings suggest the presence of abnormalities in the dopamine response to stress in negative symptom schizotypy, and provide indirect evidence of a link to frontal function.

show abstract

Structural neural networks subserving oculomotor function in first-episode schizophrenia

Abstract: Background: Smooth pursuit and antisaccade abnormalities are well documented in

Cited by 18 publications

References 79 publications

Medial Versus Lateral Frontal Lobe Contributions to Voluntary Saccade Control as Revealed by the Study of Patients with Frontal Lobe Degeneration

Medial Versus Lateral Frontal Lobe Contributions to Voluntary Saccade Control as Revealed by the Study of Patients with Frontal Lobe Degeneration

A Review: Detecting Alterations of Brain Connectivity in Schizophrenia based on Structural MRI

Stress-Induced Dopamine Release in Humans at Risk of Psychosis: a [11C]Raclopride PET Study

Contact Info

Product

Resources

About