Smoking Is Associated with Shortened Airway Cilia.

O'Mahony, MJ; Leopold, PL; Lian, XJ; Harvey, Ben-Gary; Crystal, RG

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1219

A27. Genetic and Acquired Cilia Disease 2009

DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1219

|View full text |Cite

Smoking Is Associated with Shortened Airway Cilia.

MJ O'Mahony¹,

PL Leopold²,

XJ Lian³

et al.

Abstract: Background: Whereas cilia damage and reduced cilia beat frequency have been implicated as causative of reduced mucociliary clearance in smokers, theoretically mucociliary clearance could also be affected by cilia length. Based on models of mucociliary clearance predicting that cilia length must exceed the 6-7 mm airway surface fluid depth to generate force in the mucus layer, we hypothesized that cilia height may be decreased in airway epithelium of normal smokers compared to nonsmokers.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2011

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Microscopic study of certain age‐related structural changes of maxillary sinus lining epithelium in albino rats

Abdelmalik

2011

Microscopy Res & Technique

View full text Add to dashboard Cite

Mucociliary clearance is essential to maintain the defense function of the maxillary sinus; however, no literatures described the age changes in its lining epithelium. Therefore, the current work sought to describe the morphological postnatal age-related changes of maxillary sinus lining epithelium in rats using light, transmission, and scanning electron microscopes. Eighteen albino rats were divided into six groups according to their ages: 2-week-old, 1-month-old, 2-month-old, 3-month-old, adults, and senile rats. One-month-old-rats' group was the first to have recognizable maxillary sinus cavities that were lined by either single flat cellular layer or two distinct epithelial layers. These cells were devoid of microvilli and cilia, none of them showed evidence of differentiation into identifiable cell types. In 2- and 3-month-old rats, the mucosa of maxillary sinus started to be lined with pseudostratified epithelium with apparent increase in both microvilli and cilia. The first indication of goblet cell differentiation was observed in 3-month-old-rats. In the adult rats, the sinuses became completely lined by mature respiratory epithelium. However, in senile rats the epithelium exhibited polyps with clumped cilia and some areas of stratification and desquamation. Goblet cells were scanty and degenerating. The impaired mucociliary components (epithelium, cilia, and goblet cells' mucus) found in young and old ages of the current work might be correlated to human to explain predisposition of rhino-sinusitis in these age groups.

show abstract

Microscopic study of certain age‐related structural changes of maxillary sinus lining epithelium in albino rats

Abdelmalik

2011

Microscopy Res & Technique

View full text Add to dashboard Cite

show abstract

Nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease and lung cancer

Moghaddam

Ochoa

Sethi

et al. 2011

COPD

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death in the world by 2020. It is characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lungs to noxious particles and gases, most commonly cigarette smoke. Among smokers with COPD, even following withdrawal of cigarette smoke, inflammation persists and lung function continues to deteriorate. One possible explanation is that bacterial colonization of smoke-damaged airways, most commonly with nontypeable Haemophilus influenzae (NTHi), perpetuates airway injury and inflammation. Furthermore, COPD has also been identified as an independent risk factor for lung cancer irrespective of concomitant cigarette smoke exposure. In this article, we review the role of NTHi in airway inflammation that may lead to COPD progression and lung cancer promotion.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Smoking Is Associated with Shortened Airway Cilia.

Cited by 2 publications

References 38 publications

Microscopic study of certain age‐related structural changes of maxillary sinus lining epithelium in albino rats

Microscopic study of certain age‐related structural changes of maxillary sinus lining epithelium in albino rats

Nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease and lung cancer

Contact Info

Product

Resources

About