Smoking is associated with combined allergic and irritant hand eczema, contact allergies and hyperhidrosis

Molin, Sonja; Ruzicka, Thomas; Herzinger, Thomas

doi:10.1111/jdv.12846

Cited by 30 publications

(36 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The three studies were performed on patch tested patients (43), on patients with chronic HE (44), and on patients with HE (45). For information regarding the correction for other risk factors, see Table 4.…”

Section: Results Of Other Studiesmentioning

confidence: 99%

“…The relationship between subclassification of HE and smoking was evaluated in five studies only (27,(42)(43)(44)(45); they found no significant association (42,45), a positive association with erythematous lesions and vesicles (27), a positive association with palmar eczema (43), or a positive association with combined irritant/allergic HE (44). However, HE is a heterogeneous disease: it may be that there are differences between the various subclasses of HE and factors such as smoking.…”

Section: Discussionmentioning

confidence: 99%

“…Preferably, questions concerning smoking should involve the statements 'occasionally' and 'previously', and the amount that a person smokes per day is also important, in order to explore a possible dose-response relationship. Some studies only asked whether the participants smoked or not (27,28,30,32,34,36,38,40,42,43,45), some added the term occasionally and/or previously (9,29,35,37,39,44), and some added a question on the amount of smoking (9, 29-31, 33, 35, 37, 41). Only one study took pack years into consideration (9).…”

Section: Discussionmentioning

confidence: 99%

“…However, only seven studies included all of the above listed risk factors (9,31,35,37,38,40,45) and performed a multivariate analysis controlling for these possible confounders. In a further three studies (28,41,44), risk factors were controlled for in other ways. Among these controlled studies, a positive association between smoking and HE prevalence was reported in one (28), whereas five (9,28,38,40,45) found no significant association.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Tobacco smoking and hand eczema – is there an association?

et al. 2015

View full text Add to dashboard Cite

SummaryBackground. Numerous risk factors have been suggested for hand eczema. This systematic review evaluates the association between tobacco smoking and hand eczema. Objective. To review the literature systematically on the association between smoking and hand eczema. Methods. The PubMed and EMBASE databases were searched up to 27 January 2015 for articles on the association between tobacco smoking and hand eczema, including human studies in English and German only. Experimental studies, studies on tobacco allergy, case reports, reviews and studies on second-hand smoking were excluded. Results. Twenty articles were included. Among studies in occupational settings, three of seven found a statistically significant positive association between tobacco smoking and hand eczema prevalence rate, as did four of eight population-based studies. The association was stronger for studies in occupational settings than for population-based studies. No studies reported tobacco to be a clear protective factor for hand eczema. Two of five studies regarding severity found a positive association between smoking and hand eczema severity. Conclusion. Overall, the data indicate that smoking may cause an increased frequency of hand eczema, particularly in high-risk occupations. However, data from studies controlling for other risk factors are conflicting, and few prospective studies are available. Studies controlling for other risk factors are needed, and information regarding the diagnosis of subclasses of hand eczema, as well as severity, may be important.

show abstract

Section: Results Of Other Studiesmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Tobacco smoking and hand eczema – is there an association?

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Accumulating evidence suggests that smokers are more likely to induce high airway reactivity, and allergic smoking [9] is also considered to be an important environmental factor contributing to asthma onset [10]. A survey found that tobacco consumption is on the rise around the world, at least a third of asthma patients were frequently exposed to a cigarette smoke environment [11].…”

Section: Introductionmentioning

confidence: 99%

Cigarette Smoke Extract Promotes TIM4 Expression in Murine Dendritic Cells Leading to Th2 Polarization through ERK-Dependent Pathways

Jiang

Xia

et al. 2018

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Smoking is considered to be the main source of indoor pollution, and it has been identified as an important environmental factor contributing to asthma onset. We know that T helper 2 (Th2) response plays a crucial role in the process of asthma disease. We have investigated the reaction of cigarette smoke extract (CSE) on Th polarization which is controlled by dendritic cells (DCs). Stimulated by CSE, immature DCs from murine bone marrow showed upregulated levels of TIM4. Cocultured with CD4+ T cells, stimulated DCs increased the ratio of IL-4+ versus IFN-γ+ of CD4+ T cells. This suggests a differentiation towards Th2 response. Moreover, antibodies against TIM4 reversed the upexpression of the IL-4+/IFN-γ+ ratio provoked by CSE, indicating that the Th2 polarization which was induced by CSE is via TIM4 mechanisms. CSE could activate mitogen-activated protein kinase pathways like ERK and p38. Upregulation of TIM4 expression by CSE stimulation was found to be inhibited by an ERK inhibitor but not p38 and JNK. In conclusion, DC-induced Th2 polarization is a hallmark of CSE allergy, and this aspect can be explained by CSE-induced TIM4 expression.

show abstract