Clinical Aspects of Irritant Contact Dermatitis

Brans, Richard; John, Swen Malte; Frosch, Peter J.

doi:10.1007/978-3-030-36335-2_16

Cited by 4 publications

(4 citation statements)

References 180 publications

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“…It is necessary to consider the presence of oxalic acid in S_US and L_US extracts, as this substance is irritant to the skin, causing pain (Fu et al, 2006) and dermatitis (Brans et al, 2021), even at low concentrations. Brazil (RDC 03/12) and Mercosul prohibit oxalic acid in facial cosmetics, which makes impracticable the use of these extracts.…”

Section: Discussionmentioning

confidence: 99%

Chemical characterization and toxicological analyses of hydroalcoholic extracts from the stem and leaves of mangabeira (Hancornia speciosa Gomes) as a guide for the development of green cosmetics

Panontin¹,

Neres²,

Fernandes³

et al. 2021

J. Med. Plants Res.

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The increasing interest in green cosmetics has a major influence on the cosmetics market, whether due to the incorporation of the functionalities of the extracts, or the substitution of synthetic ingredients with natural ones. Yet, the natural substances found in those products must be evaluated for their chemical characterization and toxicity. This study determined the chemical profile and assessed the toxicity of stem (S) and leaf (L) extracts of Hancornia speciosa Gomes obtained by Soxhlet apparatus (SOX) and ultrasonic-assisted extraction (US). Hydroethanolic (70%) extracts were prepared from the stem and leaves of H. speciosa resulting in Soxhlet stem extract, ultrasound stem extract, Soxhlet leaf extract, ultrasound leaf extract. The chemical characterization of the extracts was performed by phytochemical screening and the compounds were identified by GC-MS analyses. The toxicity test was analyzed at concentrations of 50, 250 and 500 µg/ml, using the Allium cepa and Artemia salina tests. The phytochemical analysis identified flavonoids, tannins and saponins while the GC-MS analysis found lupeol, hentriacontane, undecanoic acid, Friedelan-3-one and a potentially toxic substance known as oxalic acid. The toxicity test showed low genotoxic and antimutagenic indexes in the extracts of H. speciosa. The findings suggest that the safest extracts in cosmetic preparations were Soxhlet stem extract and Soxhlet leaf extract, while the most toxic extract was ultrasound leaf extract.

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Section: Discussionmentioning

confidence: 99%

Chemical characterization and toxicological analyses of hydroalcoholic extracts from the stem and leaves of mangabeira (Hancornia speciosa Gomes) as a guide for the development of green cosmetics

Panontin¹,

Neres²,

Fernandes³

et al. 2021

J. Med. Plants Res.

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“…Arbeitsbedingt manifestiert sich an den Händen häufig initial ein irritatives (kumulativ-subtoxisches) Kontaktekzem, das durch hohe Feuchtbelastung bei gleichzeitigem Umgang mit primär hautreizenden Meerestier- und/oder Fleischbestandteilen (z. B. Säfte mit Enzymaktivität) sowie oft zusätzlich auf dem Boden einer atopischen Hautdiathese ausgelöst und unterhalten wird [ 6 , 7 , 9 , 10 , 21 , 30 , 69 , 70 ]. Bei derart gestörter Hautbarriere kann sich dann im Sinne eines „Zweiphasenekzems“ eine immunologische Kontakturtikaria und mit zunehmender Chronizität eine Proteinkontaktdermatitis – Letztere als zweithäufigste Berufsdermatose bei Betroffenen mit arbeitsbedingtem Nahrungsmittelumgang [ 70 ] – aufpfropfen [ 56 ].…”

Section: Klinikunclassified

Außergewöhnliche Berufsallergien durch Nahrungsmittel tierischen Ursprungs

Dickel

2021

Hautarzt

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Zusammenfassung Hintergrund Die Nahrungsmittelwirtschaft zählt zu den Hochrisikobereichen für arbeitsbedingte allergische Sofortreaktionen an der Haut (Kontakturtikaria, Kontakturtikariasyndrom, Proteinkontaktdermatitis) mit oder ohne respiratorische Symptome (allergische Rhinitis, allergisches Asthma) durch Proteine tierischen Ursprungs. Fragestellung Die vorliegende Arbeit gibt einen Überblick über allergene Meerestier- und Fleischproteine und deren klinische und beruflich Relevanz in verschiedenen Tätigkeitsbereichen. Material und Methode Es erfolgten die Aufbereitung von aktuellem Wissen sowie eine ergänzende selektive Literaturrecherche. Ergebnisse Nach dem irritativen Handekzem ist die Proteinkontaktdermatitis eine häufige Berufsdermatose unter Beschäftigten mit Kontakt zu Meerestieren und Fleisch. Fischer, Köche und Metzger sind an erster Stelle betroffen. Noch vor den Fischen zählen Krusten- und Weichtiere zu den häufigsten Auslösern von in Einzelfällen auch vital bedrohlichen Nahrungsmittelallergien. Demgegenüber ist eine primäre Fleischallergie selten. Rindfleisch unter den Säugetieren und Hühnerfleisch unter den Vögeln sind die häufigsten Auslöser. Schlussfolgerungen Bei allen Beschäftigten mit allergischen Sofortreaktionen an der Haut und/oder den Atemwegen, die gegenüber Proteinen tierischen Ursprungs am Arbeitsplatz exponiert sind, sollte frühzeitig eine sorgfältige allergologische Abklärung durchgeführt werden. Spielt heute die spezifische Ig(Immunglobulin)E-Bestimmung bei der Diagnosesicherung eine zentrale Rolle, wird es in Einzelfällen von großer Bedeutung sein, das angeschuldigte Nativmaterial in die Hauttestungen einzubeziehen. Die Krankheitsverläufe sind allgemein durch eine schlechte Prognose und häufige Berufswechsel charakterisiert.

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“…For instance, hairdressers, healthcare workers and metal workers are at particularly high risk of developing occupational HE due to skin exposure to irritants and allergens [9][10][11][12][13][14][15][16]. Most occupational HE occur as contact dermatitis (CD) [17], predominantly as irritant contact dermatitis (ICD), caused by skin exposure to irritants (e. g., cleaning agents, detergents) [18,19], and/or allergic contact dermatitis (ACD) [20,21], resulting from skin contact to an allergen the individual patient is sensitized to (e. g., hair dyes, fragrances, rubber accelerators) [22,23]. Depending on one's genetic disposition, atopic dermatitis (AD) and psoriasis are further risk factors for developing occupational dermatoses and, in case of AD, often occur in combination with ICD [17].…”

Section: Introductionmentioning

confidence: 99%

“…The symptoms of ICD, ACD and AD are similar (e. g., itchiness, vesicles, redness). In regard to treating ICD or ACD, it is important to eliminate irritants and/or allergens causing the condition to prevent the disease from becoming chronic [18]. Besides its socio-economic impacts, both on a patient's life and society [21,25], occupational HE are associated with a high burden of disease and a reduced quality of life [26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Illness perceptions of occupational hand eczema in German patients based on the common-sense model of self-regulation: A qualitative study

et al. 2023

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Background Occupational skin diseases (OSD) in the form of hand eczema (HE) are a common work-related disease. Illness perceptions as presented in Leventhal’s Common-Sense Model (CSM) are important for patients’ self-management of diseases. Understanding these illness perceptions is essential for patient communicating. No quantitative or qualitative studies which investigated subjective illness perceptions in patients with occupational HE utilized the CSM as theoretical framework. The Objective of this study is to investigate illness perceptions of patients with occupational hand eczema (HE) using the CSM. Methods We applied an exploratory qualitative approach and conducted purposive sampling. Thirty-six patients with occupational HE were interviewed using an interview guide based on the dimensions of the CSM, including coherence and emotional representation. All participants participated in a three-week inpatient program at a clinic specialized on occupational dermatology. One interview had to be excluded before analysis, since one participant’s diagnosis was retrospectively changed from ICD to tinea and hence did not match the inclusion criteria. Thirty-five interviews were transcribed verbatim and analyzed. Data was analyzed deductively and inductively using qualitative text analysis. MAXQDA 2018 (Verbi, Berlin, Germany), a software for qualitative data analysis, was applied for coding and summarizing of results. All dimensions of the CSM were explored for occupational HE. Results Several sub-categories could be identified. Participants named a variety of causes in different areas (e. g. external irritants and other hazardous factors, psycho-social factors, allergies, having a ‘bad immune system’ or lifestyle). The great impact of the disease on the participants’ life is shown by the wide range of consequences reported, affecting all areas of life (i. e. psychological, physical, occupational, private). Considering coherence, an ambivalence between comprehensibility and non-comprehensibility of the disease is apparent. Discussion The complexity of illness perceptions presented in this paper is relevant for those involved in HE patient education and counseling, e. g, health educators, dermatologists, and, occupational physicians. Future research might further investigate specific aspects of illness perceptions in patients with occupational HE, especially considering the complexity of coherence and overlapping dimensions (i. e. emotional representation and psychological consequences).

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Clinical Aspects of Irritant Contact Dermatitis

Cited by 4 publications

References 180 publications

Chemical characterization and toxicological analyses of hydroalcoholic extracts from the stem and leaves of mangabeira (Hancornia speciosa Gomes) as a guide for the development of green cosmetics

Chemical characterization and toxicological analyses of hydroalcoholic extracts from the stem and leaves of mangabeira (Hancornia speciosa Gomes) as a guide for the development of green cosmetics

Außergewöhnliche Berufsallergien durch Nahrungsmittel tierischen Ursprungs

Illness perceptions of occupational hand eczema in German patients based on the common-sense model of self-regulation: A qualitative study

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