Smoking Increases Tissue Factor Expression in Atherosclerotic Plaques

Abstract

Our results suggest increased plaque TF expression and thrombogenicity as a novel mechanism for the increased risk of atherothrombotic events in smokers. Treatment with aspirin may reduce TF expression.

Short‐Term E‐Cigarette Exposure Increases the Risk of Thrombogenesis and Enhances Platelet Function in Mice

“…After “validating” our model, we first sought to investigate the impact of e‐cigarettes on thrombogenesis, as it is the major cause of tobacco‐induced CVD,38 including thrombosis‐based diseases 17, 77, 78, 79, 80, 81, 82, 83. Our findings revealed, for the first time, a drastic reduction in the time for carotid artery occlusion, indicating a prothrombotic phenotype, even after only a week of whole‐body exposure to e‐cigarettes.…”

The role of tissue factor in normal pregnancy and in the development of preeclampsia: A review

“…estrogen, in cigarette smokers and in hyperhomocysteinemia [32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] .…”

Effect of Smoking Status on Monocyte Tissue Factor Activity, Carotid Atherosclerosis and Long-Term Prognosis in Metabolic Syndrome

“…8-10 Cigarette smoke exposure seems to alter the balance of anti-thrombotic/prothrombotic factors by affecting the functions of EC, platelets and coagulation factors. 8, 10 The mechanisms by which smoking increases the risk of atherothrombotic events are not fully understood. Cigarette smoking confers a hypercoagulable state.…”

“…These complexes lead to thrombin formation, which in turn activates the clotting cascade and platelets. 8- 10 In addition, TF overexpression in a rat model accelerated neointimal development and thrombus formation. 12 Therefore, TF plays a significant role in both thrombus formation and in the progression of atherosclerosis.…”

“…8 Tissue factor (TF) is an initiator of the extrinsic coagulation cascade, and it is expressed in the peripheral blood monocytes and on macrophages in atherosclerotic plaque. [8][9][10] In addition, TF is expressed in EC and smooth muscle cells (SMC). 11 When a vessel wall is injured, collagen and TF become exposed to the flowing blood.…”