Smoking, Haemostatic Factors and the Severity of Aorto-lliac and Femoro-Popliteal Disease

Smith, F. B.; Lee, A J; Fowkes, F. Gerry R.; Rumley, Ann; Lowe, G. D. O.

doi:10.1055/s-0038-1650215

Cited by 15 publications

(1 citation statement)

References 39 publications

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“…These data indicate that the haemostatic processesinatherosclerosisare associated with the anatomical as well as the functional severity of PA D. To our knowledge,n op reviouss ingle studyh as investigatedthe relationshipbetween haemostatic markers and all three diagnostic measurementsofP AD used in our study. Onlylimitednumbersofstudieshaveincludedangiography as ameasureofthe degree of PA D. Our finding of astrong association between the angiographic scoreand D-dimer confirms the findings of Wo odburn, et al (26).Conflicting resultse xist, however, as other reports shownosuch correlation (27).There are also reports claiming angiographic scoretobepredicted by fibrinogen and vWF,which contrasts to our results (27,28). This is, to our knowledge,the first studyshowing the levels of TAT being predictive of the extent of atherosclerosis assessedasangiographic score.…”

Section: Discussionsupporting

confidence: 84%

Prothrombotic activity is associated with the anatomical as well as the functional severity of peripheral arterial occlusive disease

Nylænde¹,

Kroese²,

Stranden³

et al. 2006

Thromb Haemost

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The importance of prothrombotic activity in cardiovascular disease has been well established. However, limited data exist on the relationship between prothrombotic activity and the severity of peripheral arterial occlusive disease (PAD). The objective of the present study was to investigate the relationship between markers of haemostasis and the diagnostic measures of PAD: ankle-brachial-index (ABI), maximum treadmill walking distance and angiographic score. In a cross-sectional study of 127 patients (mean age 66 years; 64% males) with angiographically verified PAD, fasting blood samples were drawn, and citrated plasma was obtained for determination of selected haemostatic variables: von Willebrand factor (vWF), thrombomodulin (sTM), thrombin-antithrombin complex (TAT), soluble tissue factor (sTF), tPA antigen (tPAag) and D-dimer were all significantly correlated with the angiographic score (p < 0.05 for all). D-dimer, tPAag and fibrinogen were inversely correlated with the maximum treadmill walking distance, (p < 0.0001, p < 0.04 and p < 0.05, respectively), whereas fibrinogen was the only variable correlating to ABI (r = -0.223, p < 0.05). After adjustment for relevant covariates, D-dimer and TAT remained statistically significantly associated with the angiographic score (p < 0.001), and fibrinogen was, independent of other risk factors, inversely related with both the maximum treadmill walking distance and the ABI (p < 0.01 for both). This rather large study in patients with PAD showed that plasma levels of D-dimer, TAT and fibrinogen significantly predicted the extent of atherosclerosis, evaluated by angiographic score, maximum treadmill walking distance and ABI, respectively. These findings demonstrate a prothrombotic state in PAD patients, which might be of importance in future diagnosis and treatment of the disease.

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Section: Discussionsupporting

confidence: 84%

Prothrombotic activity is associated with the anatomical as well as the functional severity of peripheral arterial occlusive disease

Nylænde¹,

Kroese²,

Stranden³

et al. 2006

Thromb Haemost

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Synergistic Impact of Nicotine and Shear Stress Induces Cytoskeleton Collapse and Apoptosis in Endothelial Cells

et al. 2015

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Nicotine is the major component in cigarette smoke and has been recognized as a risk factor for various cardiovascular diseases such as atherosclerosis. However, the definite pathogenesis of nicotine-mediated endothelial dysfunction remains unclear because hemodynamic factor in most of prior in vitro studies was excluded. To understand how nicotine affects endothelium in the dynamic environment, human umbilical vein endothelial cells were treated by different laminar shear stresses (LSS; 0, 6, 8, and 12 dynes cm(-2)) with and without 10(-4) M nicotine for 12 h in a parallel plate flow system, following detections of cellular morphology and apoptotic level. Our results showed that cells sheared by 12 dynes cm(-2) LSS with nicotine excessively elongated and aligned with the flow direction, and exhibited significant apoptosis as compared to the groups with nicotine or LSS alone. We reasoned that the irregular morphological rearrangement and elevated apoptosis were resulted from the interruption of mechanostasis due to cytoskeletal collapse. Furthermore, all the impaired responses can be rescued by treatment with free radical scavenger ascorbic acid (10(-4) M), indicating oxidative stress was likely mediated with the impairments. In summary, our findings demonstrated an essential role of LSS in nicotine-mediated endothelial injury occurring in the physiological environment.

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Laminar Shear Stress Promotes Nicotine-Induced Inflammation and Hemostatic Expression in Human Endothelial Cells

Lee

Huang

et al. 2016

Cel. Mol. Bioeng.

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Smoking, Haemostatic Factors and the Severity of Aorto-lliac and Femoro-Popliteal Disease

Cited by 15 publications

References 39 publications

Prothrombotic activity is associated with the anatomical as well as the functional severity of peripheral arterial occlusive disease

Prothrombotic activity is associated with the anatomical as well as the functional severity of peripheral arterial occlusive disease

Synergistic Impact of Nicotine and Shear Stress Induces Cytoskeleton Collapse and Apoptosis in Endothelial Cells

Laminar Shear Stress Promotes Nicotine-Induced Inflammation and Hemostatic Expression in Human Endothelial Cells

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