Smoking Cessation Rapidly Increases Circulating Progenitor Cells in Peripheral Blood in Chronic Smokers

Kondo, Takahisa; Hayashi, Mutsuharu; Takeshita, Kyosuke; Numaguchi, Yasushi; Kobayashi, Koichi S.; Iino, Shigeo; Inden, Yasuya; Murohara, Toyoaki

doi:10.1161/01.atv.0000135655.52088.c5

Cited by 407 publications

(344 citation statements)

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“…Nevertheless, these findings accord with the results of previous papers, in which smoking was demonstrated to decrease circulating EPC numbers. 25,40 Surprisingly, there were no significant correlations between the smoking status and the EPC-specific mRNA levels as evaluated by real-time quantitative RT-PCR. It is important to note, however, that because our patients and controls were carefully matched for smoking habits and because patients had always significantly lower EPC counts (both in the case of immature and mature EPCs, independent of their smoking status), the significant decrease of EPC numbers and the tendency toward lower EPC-specific marker levels in the patient group are presumably attributable only to depression in the current study.…”

Section: Discussionmentioning

confidence: 89%

“…Because cigarette smoking has recently been demonstrated to decrease circulating EPC numbers, 25,40 patients and controls were matched for smoking habits, as shown in Table 1. In addition, smoker and non-smoker subgroups of patient and control populations were also matched for age.…”

Section: Resultsmentioning

confidence: 99%

“…20 A further established risk factor recognized today in the pathogenesis of arteriosclerosis and cardiovascular disorders is depression. However, although an association between mood disorders and susceptibility to cardiovascular events has been discovered by several researchers, 2,3,7-12,41-44 and altered circulating EPC levels have been reported in various conditions associated with vascular diseases, [20][21][22][23][24][25] to date no studies have attempted to evaluate the significance of EPCs in patients with major depression. Therefore, we investigated the significance of EPC numbers in our study sample by using flow cytometry and found a significant decrease in both mature (CD34 þ / VEGFR2 þ ) and immature (CD133 þ /VEGFR2 þ ) circulating EPC numbers in depressed patients versus healthy controls, and moreover, a statistically significant inverse relationship between EPC counts and the severity of depression independent of EPC phenotypes (as assessed by BDI scores 33 ).…”

Section: Discussionmentioning

confidence: 99%

“…Based on smoking behavior, the following categories were used: 'non-smokers' (ex-and never smokers) and 'current smokers.' Based on the observations of Kondo et al 25 on the effects of smoking cessation on EPC levels, ex-smokers were defined as those who had quit smoking at least 1 month before taking the blood sample. The control group included 16 individuals matched for age, gender and smoking status ( Table 1).…”

Section: Clinical Datamentioning

confidence: 99%

“…[15][16][17][18] Since their identification by Asahara et al, 19 several studies have shown reduced numbers and/or impaired function of EPCs in a variety of cardiovascular risk states, including diabetes mellitus, 20 hypercholesterolemia, 21 hypertension, 22 chronic renal failure, 23 rheumatoid arthritis 24 and cigarette smoking. 25 Alternatively, cardiovascular protective factors such as exercise training, 26 statin therapy, 27 angiotensin II receptor antagonists 28 and peroxisome proliferatoractivated receptor agonists 29 are known to increase EPC number and function.…”

Section: Introductionmentioning

confidence: 99%

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Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul

Döme

Teleki²,

Rihmer

et al. 2008

Mol Psychiatry

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Although depression is known to be an independent risk factor for cardiovascular disorders, the mechanisms behind this connection are not well understood. However, the reduction in the number of endothelial progenitor cells (EPCs) in patients with cardiovascular risk factors has led us to hypothesize that depression influences the number of EPCs. EPCs labeled with CD34, CD133 and vascular endothelial growth factor receptor-2 (VEGFR2) antibodies were counted by flow cytometry in the peripheral blood (PB) of 33 patients with a current episode of major depression and of 16 control subjects. Mature (CD34 þ /VEGFR2 þ ) and immature (CD133 þ / VEGFR2 þ ) EPC counts were decreased in patients (vs controls; P < 0.01 for both comparisons), and there was a significant inverse relationship between EPC levels and the severity of depressive symptoms (P < 0.01 for both EPC phenotypes). Additionally, we assayed the plasma levels of VEGF, C-reactive protein (CRP) and tumor necrosis factor (TNF)-a and observed significantly elevated TNF-a concentrations in patients (vs controls; P < 0.05) and, moreover, a significant inverse correlation between TNF-a and EPC levels (P < 0.05). Moreover, by means of a quantitative RT-PCR approach, we measured CD34, CD133 and VEGFR2 mRNA levels of PB samples and found a net trend toward a decrease in all the investigated EPC-specific mRNA levels in patients as compared with controls. However, statistical significance was reached only for VEGFR2 and CD133 levels (P < 0.01 for both markers). This is the first paper that demonstrates evidence of decreased numbers of circulating EPCs in patients with a current episode of major depression.

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Section: Discussionmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Clinical Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul

Döme

Teleki²,

Rihmer

et al. 2008

Mol Psychiatry

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Prediagnosis Smoking Cessation and Overall Survival Among Patients With Non–Small Cell Lung Cancer

et al. 2023

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ImportanceLung cancer remains the leading cause of cancer-related death globally; non–small cell lung cancer (NSCLC) accounts for 85% of all lung cancer cases, and cigarette smoking is the factor most significantly associated with its risk. However, little is known about the association of years since prediagnosis smoking cessation and cumulative smoking with overall survival (OS) following a lung cancer diagnosis.ObjectiveTo characterize the association of years since smoking cessation before diagnosis and cumulative smoking pack-years with OS in patients with NSCLC in a lung cancer survivor cohort.Design, Setting, and ParticipantsThe cohort study involved patients with NSCLC who were recruited to the Boston Lung Cancer Survival Cohort at Massachusetts General Hospital (Boston, Massachusetts) between 1992 and 2022. Patients’ smoking history and baseline clinicopathological characteristics were prospectively collected through questionnaires, and OS following lung cancer diagnosis was regularly updated.ExposuresDuration of smoking cessation before a lung cancer diagnosis.Main Outcomes and MeasuresThe primary outcome was the association of detailed smoking history with OS following a lung cancer diagnosis.ResultsOf 5594 patients with NSCLC (mean [SD] age, 65.6 [10.8] years; 2987 men [53.4%]), 795 (14.2%) were never smokers, 3308 (59.1%) were former smokers, and 1491 (26.7%) were current smokers. Cox regression analysis suggested that former smokers had 26% higher mortality (hazard ratio [HR], 1.26; 95% CI, 1.13-1.40; P &lt; .001) and current smokers had 68% higher mortality (HR, 1.68; 95% CI, 1.50-1.89; P &lt; .001) compared with never smokers. Log2-transformed years since smoking cessation before diagnosis were associated with significantly lower mortality among ever smokers (HR, 0.96; 95% CI, 0.93-0.99; P = .003). Subgroup analysis, stratified by clinical stage at diagnosis, revealed that former and current smokers had even shorter OS among patients with early-stage disease.Conclusions and RelevanceIn this cohort study of patients with NSCLC, quitting smoking early was associated with lower mortality following a lung cancer diagnosis, and the association of smoking history with OS may have varied depending on clinical stage at diagnosis, potentially owing to the differing treatment regimens and efficacy associated with smoking exposure following diagnosis. Detailed smoking history collection should be incorporated into future epidemiological and clinical studies to improve lung cancer prognosis and treatment selection.

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Peripheral Arterial Disease

2006

Wiley Handbook of Current and Emerging Drug Therapies

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Professor 'Strandness's book is a stimulating analysis of modem methods of investigation of arterial disease, with special emphasis on physiology and pathology. Much of the book deals with his own research into vascular disease. There are interesting chapters on vascular pathology illustrated by silastic casts of diseased arteries. Original views are expressed on the pathology of arterial disease in diabetics. New advances in methods of blood flow measurement are described using strain gauge plethysmography, electromagnetic flowmetry and, most recently, ultrasound.

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Smoking Cessation Rapidly Increases Circulating Progenitor Cells in Peripheral Blood in Chronic Smokers

Cited by 407 publications

References 31 publications

Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul

Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul

Prediagnosis Smoking Cessation and Overall Survival Among Patients With Non–Small Cell Lung Cancer

Peripheral Arterial Disease

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