Smoking and the Association of Advanced Colorectal Neoplasia in an Asymptomatic Average Risk Population: Analysis of Exposure and Anatomical Location in Men and Women

Anderson, Joseph C.; Moezardalan, Koorosh; Messina, Catherine R.; Latreille, Michael; Shaw, Robert D.

doi:10.1007/s10620-011-1814-8

Cited by 26 publications

(16 citation statements)

References 42 publications

(57 reference statements)

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“…Furthermore, the 50% prevalence of adults in the NHCR who had a smoking exposure, past or current, has also been observed in other similar screening populations 11 . Therefore, while adjustment for smoking or obesity may be needed in a population with a particularly high prevalence of these risk factors, especially if many individuals have a 20 pack year or greater exposure, stratification may not be necessary in typical screening populations.…”

Section: Discussionsupporting

confidence: 60%

Adenoma Detection Rates for Screening Colonoscopies in Smokers and Obese Adults

Anderson

Weiss

Robinson³

et al. 2017

Journal of Clinical Gastroenterology

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Goal To examine screening adenoma detection rates (ADR) and serrated detection rates (SDR) among smokers and obese adults in the New Hampshire Colonoscopy Registry. Background ADR, a quality measure for screening colonoscopies, is associated with protection from interval colorectal cancer (CRC). Currently, only sex-specific ADR benchmarks are reported. However, obesity and smoking ≥ 20 pack-years are strong predictors for colorectal neoplasia, as highlighted by the 2009 American College of Gastroenterology CRC Screening Guidelines. Data comparing ADR in smokers and obese adults to those without these risks are limited. Study We calculated ADR, SDR and 95% confidence intervals for screening colonoscopies in participants ≥ 50 years. Sex and sex-age specific rates were compared by smoking exposure (never versus < 20 pack-years versus ≥ 20 pack-years) and body mass index (BMI < 30 versus BMI ≥ 30). Results 21,539 screening colonoscopies were performed by 77 endoscopists at 20 facilities (4/2009 -9/2013). The difference in ADR between non-smokers and smokers with ≥ 20 pack-years was 8.8% (p < 0.0001) and between obesity groups 5.0% (p<0.0001). Significant sex specific and sex-age specific increases in ADR and SDR were found among smokers and obese participants. Conclusions ADR and SDR for smokers and obese adults were significantly higher than their counterparts without those risks. Endoscopists should consider the prevalence of these risks within their screening population when comparing their rates to established benchmarks. Calculating sex or sex-age specific ADR and SDR based on smoking and obesity may provide optimal protection for populations with a particularly high prevalence of smokers and obese adults.

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Section: Discussionsupporting

confidence: 60%

Adenoma Detection Rates for Screening Colonoscopies in Smokers and Obese Adults

Anderson

Weiss

Robinson³

et al. 2017

Journal of Clinical Gastroenterology

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“…In addition, we showed in a large screening cohort with an almost equal distribution of men and women that the association was significantly stronger for women. A study on 1996 individuals investigated the impact of exposure level of smoking, and revealed that female smokers had an increase risk for advanced adenomas compared with non-smokers at a lower exposure level than man (Anderson et al , 2011). Exposure levels were not assed in the present study.…”

Section: Resultsmentioning

confidence: 99%

Risk factors cannot explain the higher prevalence rates of precancerous colorectal lesions in men

et al. 2016

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“…Compared with their non-smoker peers, women smokers are at significantly greater risk of advanced colorectal neoplasia after as little as 10 pack-years of smoking, whereas for men it takes 30 or more pack-years for the risk to reach statistical significance [13]. Previous studies revealed a gender difference in the effect of smoking on bladder cancer risk; however, one recent study following approximately 500,000 participants reported that smokers, regardless of gender, were at a 50 % higher risk for developing bladder cancer compared with never smokers [14].…”

Section: Smoking and Cancermentioning

confidence: 99%

Women and Smoking: The Effect of Gender on the Epidemiology, Health Effects, and Cessation of Smoking

2014

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Smoking is still the leading cause of premature morbidity and mortality. This paper examines new research on gender differences and the epidemiology of smoking, smoking-related morbidity and mortality, and factors that affect smoking cessation. The rate of decline in the prevalence of smoking has been slowing, especially among adolescent girls. New research suggests that, compared with men, women may be more susceptible to smoking-related morbidity and mortality. Gender-related barriers to smoking cessation include weight gain, sex hormones, and mood. Furthermore, the sensory aspects of smoking may have more of an effect on smoking treatment for women than for men. We discuss new studies that examine smoking-cessation interventions that may be particularly beneficial for women, including exercise (as an adjunct intervention), very low nicotine content cigarettes, and a variety of pharmacotherapy. Further research is needed to identify and target the gender-specific needs of smokers.

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Smoking and the Association of Advanced Colorectal Neoplasia in an Asymptomatic Average Risk Population: Analysis of Exposure and Anatomical Location in Men and Women

Abstract: Women smokers had an increased risk for advanced adenomas at a lower exposure level and had a greater risk for proximal lesions. These findings may have an impact on CRC screening for women.

Cited by 26 publications

References 42 publications

Adenoma Detection Rates for Screening Colonoscopies in Smokers and Obese Adults

Adenoma Detection Rates for Screening Colonoscopies in Smokers and Obese Adults

Risk factors cannot explain the higher prevalence rates of precancerous colorectal lesions in men

Women and Smoking: The Effect of Gender on the Epidemiology, Health Effects, and Cessation of Smoking

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