Smoking and substance abuse in outpatients with schizophrenia: a 2-year follow-up study in Turkey

Uzun, Özcan; Cansever, Adnan; Başoğlu, Cengiz; Özşahin, Aytekin

doi:10.1016/s0376-8716(02)00362-9

Cited by 27 publications

(22 citation statements)

References 31 publications

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“…In all, 93% of the smokers and 91% of the nonsmokers were of Caucasian ethnicity (Table 1). The nonsmokers fraction in our sample is 38% a number higher than the reported 15% of hospitalized schizophrenics; however, our sample consists of mostly outpatients who are less prone to smoke (Uzun et al, 2003).…”

Section: Methodsmentioning

confidence: 75%

Evidence of Association between Smoking and α7 Nicotinic Receptor Subunit Gene in Schizophrenia Patients

Luca

Wong

Müller

et al. 2004

Neuropsychopharmacol

105

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A number of studies have suggested that the a-7-nicotinic receptor D15S1360 polymorphism is associated with schizophrenia and a deficiency in the normal inhibition of the P50 auditory-evoked response. Schizophrenia patients and some of their unaffected relatives show a failure of inhibition in their 50-ms response to the second of a pair of tones. Biochemical studies have suggested that the a7 nicotinic acetylcholine receptor is involved in this sensory gating deficit. Furthermore, high-dose nicotine transiently normalizes the abnormality in P50 inhibition in schizophrenic patients and in their relatives. Schizophrenic patients are unusually heavy smokers, and up to 85% of hospitalized schizophrenic patients smoke. This rate is three times higher than the general population, and may represent an attempt to self-medicate through this pathophysiologic mechanism. Despite schizophrenics' extremely heavy nicotine use, nicotinic receptor genes have not been previously investigated in relation to smoking in schizophrenia. In this study, we hypothesized that the D15S1360 marker is associated with smoking in patients with schizophrenia. We found an association between the homozygous 113 bp allele and smoking risk (w 2 ¼ 10.37, 3 df, p ¼ 0.015). Although this novel finding requires replication, it suggests that further study into the relationship between schizophrenia and nicotine system genes is warranted.

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Section: Methodsmentioning

confidence: 75%

Evidence of Association between Smoking and α7 Nicotinic Receptor Subunit Gene in Schizophrenia Patients

Luca

Wong

Müller

et al. 2004

Neuropsychopharmacol

105

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“…Herrán et al (2000) encontraram uma prevalência de 64% de tabagismo em esquizofrênicos, em um levantamento efetuado na Espanha. No estudo de Uzun et al (2003), realizado na Turquia, foi encontrada uma prevalência de 50%. Embora o consumo de tabaco esteja decrescendo na população como um todo, esquizofrênicos permanecem fumando em índices alarmantes e sofrendo as conseqüências maléficas do tabagismo à saúde (Mc Cloughen, 2003).…”

Section: Tabagismo E Esquizofreniaunclassified

“…Com base em análises de casos clínicos, Valença et al (2001), por exemplo, consideram que o consumo de tabaco não deve ser considerado fator etiológico exclusivo em nenhum caso de TP e que ainda são necessários mais estudos destinados a esclarecer os possíveis mecanismos etiopatogênicos comuns ao tabagismo e essa doença, bem como responder a questões terapêuticas específicas.…”

Section: Tabagismo E Transtorno De Pânicounclassified

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Relação entre tabagismo e transtornos psiquiátricos

Rondina¹,

Gorayeb

Botelho

2003

Rev. psiquiatr. clín.

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RESUMOEste artigo apresenta uma revisão não sistemática da literatura sobre a relação entre tabagismo e doenças mentais, destacando algumas perspectivas recentes sobre o assunto. Buscou-se identificar e descrever as hipóteses levantadas por estudiosos nas últimas décadas acerca da natureza da associação entre o tabagismo e as perturbações psiquiátricas como depressão maior, esquizofrenia e transtornos de ansiedade. Discutem-se, também, as reflexões sobre as abordagens utilizadas nas pesquisas, bem como as possíveis contribuições desse conhecimento para os programas de intervenção e assistência a pacientes psiquiátricos fumantes. Unitermos: Tabagismo; Transtornos psiquiátricos. ABSTRACT Relationship between smoking behavior and psychiatric disordersThis paper presents a non systematic literature review on the relationship between smoking behavior and psychiatric disorders, pointing out the new perspectives on the matter. The aim was to identify and describe the hypotheses on the nature of the association between smoking and major depression, schizophrenia and anxiety disorders, in the last decades. The different research approaches, as well as the possible contributions of this knowledge to intervention programs to assist smokers psychiatric patients are discussed. Keywords: Smoking behavior; Psychiatric disorders.

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“…Smoking rates in schizophrenia patients have been reported to be 50-67% in outpatients, 57.5% in outpatients and inpatients, and 72.3% in inpatients (21)(22)(23)(24)(25). In another study involving schizophrenia, bipolar disorder and depression inpatients, the smoking rate was found as 70% (26).…”

Section: Introductionmentioning

confidence: 99%

Cigarette Consumption and Related Factors in Schizophrenia, Schizoaffective Disorder and Delusional Disorder

Boşgelmez¹,

Yıldız²

2017

Dusunen Adam

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Cigarette consumption and related factors in schizophrenia, schizoaffective disorder and delusional disorderObjective: The present study is designed to assess the rate of smoking and related factors in outpatients with schizophrenia, schizoaffective disorder and delusional disorder.Methods: Medical records of 541 patients, diagnosed with schizophrenia, schizoaffective disorder and delusional disorder according to DSM-IV were examined retrospectively. Daily cigarette consumption, sociodemographic characteristics and medical data of the patients were evaluated. Logistic regression analysis was conducted to determine the factors associated with smoking. Correlation analysis was performed to assess factors related with daily cigarette consumption.Results: Of the 541 patients, 242 (44.7%) were current smokers. Smoking rate was significantly higher in males. Although there were differences in sociodemographic characteristics and disorder related variables, there was no difference in smoking rates of patients with schizophrenia, schizoaffective disorder, and delusional disorder. In logistic regression analysis it was shown that smoking was associated with male gender and violent behavior after illness onset in psychotic disorders. Correlation analysis showed that mean number of daily consumed cigarettes correlated moderately with the duration of the illness. Conclusions:In the study, similar smoking rates were found between psychotic disorders. Smoking is strongly related with male gender and violent behavior after onset of illness. The relation between smoking and violent behavior emerges as a new field deserving further investigation.Keywords: Delusional disorder, psychotic disorders, schizoaffective disorder, schizophrenia, smoking ÖZET Şizofreni, şizoaffektif bozukluk ve sanrılı bozuklukta sigara tüketimi ve ilişkili etmenler Amaç: Bu çalışmada ayaktan tedavi gören şizofreni, şizoaffektif bozukluk ve sanrılı bozukluk hastalarında sigara kullanma sıklığını ve bununla ilişkili etmenleri belirlemek amaçlanmıştır.Yöntem: DSM-IV'e göre şizofreni, şizoaffektif bozukluk ve sanrılı bozukluk tanısı alan 541 hastanın dosyası geriye dönük olarak incelendi. Hastaların günlük sigara kullanma miktarı, nüfus özellikleri ve hastalıklarıyla ilişkili dosya verileri değerlendirildi. Sigara içimiyle ilişkili etmenleri belirlemek için lojistik regresyon, günlük sigara tüketimi miktarıyla ilişkili etmenleri araştırmak için korelasyon analizi kullanıldı.Bulgular: Çalışmaya dahil edilen 541 hastanın %44.7'sinin (n=242) düzenli olarak sigara kullandığı belirlendi.Erkeklerin sigara kullanma oranı kadınlarınkinden anlamlı derecede yüksekti. Şizofreni, şizoaffektif bozukluk ve sanrılı bozukluk hastalarında çalışmada ele alınan nüfus özellikleri ve hastalıklarıyla ilişkili değişkenler açısından farklılıklar olmasına rağmen, sigara içimi sıklığı bakımından fark saptanmadı. Lojistik regresyon analizi uygulandığında psikotik bozukluklarda sigara kullanımının, erkek cinsiyet ve hastalandıktan sonraki şiddet davranışı ile ilişkili olduğu sa...

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Smoking and substance abuse in outpatients with schizophrenia: a 2-year follow-up study in Turkey

Cited by 27 publications

References 31 publications

Evidence of Association between Smoking and α7 Nicotinic Receptor Subunit Gene in Schizophrenia Patients

Evidence of Association between Smoking and α7 Nicotinic Receptor Subunit Gene in Schizophrenia Patients

Relação entre tabagismo e transtornos psiquiátricos

Cigarette Consumption and Related Factors in Schizophrenia, Schizoaffective Disorder and Delusional Disorder

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