Smoking and Risk of Ischemic Stroke in Young Men

Markidan, Janina; Cole, John W.; Cronin, Carolyn A.; Merino, José G.; Phipps, Michael; Wozniak, Marcella A.; Kittner, Steven J.

doi:10.1161/strokeaha.117.018859

Cited by 100 publications

(83 citation statements)

References 9 publications

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“…Similar to previous studies [23][24][25], current smoking was found to be an independent risk factor associated with 1-year stroke recurrence after MIS. After stroke, persistent smoking increases the risk of stroke recurrence.…”

Section: Discussionsupporting

confidence: 89%

Risk factors affecting the 1-year outcomes of minor ischemic stroke: results from Xi’an stroke registry study of China

Liu

Lin

et al. 2020

BMC Neurol

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Background The prevalence of stroke recurrence, disability, and all-cause mortality of patients with minor ischemic stroke (MIS) remains problematic. The aim of the present study was to identify risk factors associated with adverse outcomes at 1 year after MIS in the Xi’an region of China. Methods This prospective cohort study included MIS patients above 18 years old with National Institutes of Health Stroke Scale (NIHSS) score ≤ 3 who were treated in any of four hospitals in Xi’an region of China between January and December 2015. The 1-year prevalence of stroke recurrence, disability, and all-cause mortality were evaluated, respectively. Multivariate logistic regression analysis was performed to assess the association between the identified risk factors and clinical outcomes. Results In this study, 131(10.5%, 131/1252) patients were lost to follow-up at 1 year. A total of 1121 patients were included for analysis, the prevalence of stroke recurrence, disability, and all-cause mortality at 1 year after MIS were 3.4% (38/1121), 9.3% (104/1121), and 3.3% (37/1121), respectively. Multivariate logistic regression analysis identified age, current smoking, and pneumonia as independent risk factors for stroke recurrence. Age, pneumonia, and alkaline phosphatase were independent risk factors for all-cause mortality. Independent risk factors for disability were age, pneumonia, NIHSS score on admission, and leukocyte count. Conclusions The 1-year outcomes of MIS in Xi’an region of China were not optimistic, especially with a high prevalence of disability. The present study indicated that age and pneumonia were the common independent risk factors affecting the 1-year outcomes of MIS in Xi’an region of China.

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Section: Discussionsupporting

confidence: 89%

Risk factors affecting the 1-year outcomes of minor ischemic stroke: results from Xi’an stroke registry study of China

Liu

Lin

et al. 2020

BMC Neurol

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“…In addition, over the last decade smoking is more frequently seen in young adults 54 55. A stronger dose-response relationship between smoking and the risk of ischaemic stroke is found for both men and women at young age compared with older adults 71 72. In stroke patients of all ages, the highest prevalence is reported in Europe (28.7%) and in Southeast Asia (24.8%), whereas the lowest prevalence was reported in Africa (13.9%).…”

Section: Vascular Risk Factors From Global Perspectivementioning

confidence: 99%

Ischaemic stroke in young adults: a global perspective

Boot¹,

Ekker²,

Putaala

et al. 2020

J Neurol Neurosurg Psychiatry

169

147

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Ischaemic stroke at young age is an increasing problem in both developing and developed countries due to rising incidence, high morbidity and mortality and long-term psychological, physical and social consequences. Compared with stroke in older adults, stroke in young adults is more heterogeneous due to the wide variety of possible underlying risk factors and aetiologies. In this review, we will provide an overview of the global variation in the epidemiology of stroke in young adults, with special attention to differences in geography, ethnicity/race and sex, as well as traditional and novel risk factors for early-onset ischaemic stroke, such as air pollution. Understanding global differences is an important prerequisite for better region-specific prevention and treatment of this devastating condition.

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“…26,27 In addition, we found that smoking was associated with an increased risk of mortality among individuals with cerebrovascular disease, which was also consistent with the results of other studies. 28,29 Studies have reported that smoking can damage blood vessels by causing them to thicken and narrow, which may lead to stroke 30 and coronary heart disease. 31 However, we did not find a significant association between smoking and the risk of mortality among patients with cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Association of Silica Dust Exposure and Cigarette Smoking With Mortality Among Mine and Pottery Workers in China

et al. 2020

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IMPORTANCE The joint association of long-term silica dust exposure and cigarette smoking with mortality has not been well established. OBJECTIVE To evaluate the joint association of silica dust exposure and cigarette smoking with mortality in a large cohort of workers at mines and factories in China. DESIGN, SETTING, AND PARTICIPANTS This cohort study included 44 708 adults who were employed in 20 metal mines and 9 pottery factories in central and southern China for at least 1 year

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Smoking and Risk of Ischemic Stroke in Young Men

Abstract: We found a strong dose-response relationship between the number of cigarettes smoked daily and ischemic stroke among young men. Although complete smoking cessation is the goal, even smoking fewer cigarettes may reduce the risk of ischemic stroke in young men.

Cited by 100 publications

References 9 publications

Risk factors affecting the 1-year outcomes of minor ischemic stroke: results from Xi’an stroke registry study of China

Risk factors affecting the 1-year outcomes of minor ischemic stroke: results from Xi’an stroke registry study of China

Ischaemic stroke in young adults: a global perspective

Association of Silica Dust Exposure and Cigarette Smoking With Mortality Among Mine and Pottery Workers in China

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