Ingestion of tobacco is detrimental to overall health that could affect the normal function of several health parameters in the human body. While it has been generally documented that smoking is injurious to health, the influence of tobacco on certain health parameters with regards to the duration of smoking in individuals without any apparent health issues is yet to be fully investigated. The current study investigated the effect of smoking on health parameters of healthy male smokers. A total of 107 (37 ± 9.42) years were enlisted randomly from different locations in Malaysia and several health-related parameters were measured. A kmeans cluster analysis was employed to classify the smokers into groups based on their smoking period while analysis of variance (ANOVA) was used to examine the differences in the health parameters status of the smokers. The k-means clustering analysis identified two distinct groups namely; chronic and acute smokers whilst the ANOVA indicated that the chronic smokers are older and characterised with a considerably higher diastolic blood pressure levels, total cholesterol, visceral fat, leptin as well as high and low-density lipoprotein. Moreover, chronic smokers are found to be highly dependent on nicotine p < 0.05. Nonetheless, no significant difference was found in basal metabolic rate systolic blood pressure, heart rate, nicotine level as well as calories intake amongst the smoking groups p > 0.05. The long-term smokers are predisposed to higher risks of cardiovascular-related problems, high fat accumulation as well as dependence on nicotine, among others.