Smoking and Bladder Cancer in Spain: Effects of Tobacco Type, Timing, Environmental Tobacco Smoke, and Gender

Samanic, Claudine; Kogevinas, Manolis; Dosemeci, Mustafa; Malats, Núria; Real, Francisco X.; García-Closas, Montserrat; Serra, Consol; Carrato, Alfredo; García-Closas, Reina; Sala, María; Lloreta, Josep; Tardón, Adonina; Rothman, Nathaniel; Silverman, Debra T.

doi:10.1158/1055-9965.epi-06-0021

Cited by 156 publications

(141 citation statements)

References 35 publications

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“…In the Lebanese context, however, this finding is particularly important, given the alarming smoking epidemic, mainly water-pipe smoking, that is invading the country since the early 1990s (Saade et al, 2008;Nakkash et al, 2011). Our results show statistically significant differences in smoking severity in cases compared to controls, which is consistent with previous findings (Samanic et al, 2006;WilhelmBenartzi et al, 2011). Our results on occupational exposure to diesel fumes are also in agreement with the reported literature (Iyer et al, 1990).…”

Section: Discussionsupporting

confidence: 90%

Urinary Bladder Cancer Risk Factors: A Lebanese Case-Control Study

Kobeissi

Yassine²,

Jabbour³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 90%

Urinary Bladder Cancer Risk Factors: A Lebanese Case-Control Study

Kobeissi

Yassine²,

Jabbour³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Among these, polycyclic aromatic hydrocarbons (PAHs) and volatile N-nitrosamines are considered to be the main carcinogens (Shields, 2002;Alam et al, 2008;Lodovici and Bigagli, 2009). Smoking exposure-a welldocumented environmental factor-is a leading cause of many types of cancer such as lung, esophageal, gastric, bladder, liver and cervical cancers (Tredaniel et al, 1997;Kinjo et al, 1998;Gallus et al, 2001;Sobue et al, 2002 ;Settheetham-Ishida et al, 2004;Samanic et al, 2006;Settheetham-Ishida et al, 2006;Syrjanen et al, 2007;Pesch et al, 2011). An increased risk of cervical cancer associated with tobacco smoking has been found in many studies (Haverkos et al, 2003;SettheethamIshida et al, 2004;Garland et al, 2011;Yetimalar et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Natphopsuk

Settheetham-Ishida²,

Sinawat³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is a serious public health problem in Thailand. We investigated possible risk factors for cervical cancer including HPV infection, p53 polymorphism, smoking and reproductive history among women in Northeast Thailand using a case control study with 177 cases and age-matched controls. Among the HPV carriers, a significantly increased risk for cervical cancer with an OR of 36.97 (p<0.001) and an adjusted OR of 38.07 (p<0.001) were observed. Early age at first sexual exposure, and multiple sexual partners increased the risk of cervical cancer with ORs ranging between 1.73-2.78 (p<0.05). The interval between menarche and first sexual intercourse <6 years resulted in a significant increase in the risk for cervical cancer with ORs ranging between 3.32-4.09 and the respective adjusted OR range for the 4-5 and 2-3 year-old groups were 4.09 and 2.92. A higher risk was observed among subjects whose partner had smoking habits, whether currently or formerly; with respective ORs of 3.36 (p<0.001) and 2.17 (p<0.05); and respective adjusted ORs of 2.90 (p<0.05) and 3.55 (p<0.05). Other smoking characteristics of the partners including smoking duration ≥ 20 years, number of cigarettes smokes ≥ 20 pack-years and exposure time of the subject to passive smoking ≥ 5 hrs per day were found to be statistically significant risks for cervical cancer with adjusted ORs of 3.75, 4.04 and 11.8, respectively. Our data suggest that the risk of cervical cancer in Thai women is substantially associated with smoking characteristics of the partner(s), the interval between menarche and first sexual intercourse as well as some other aspects of sexual behavior.

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“…in men (Samanic et al 2006). Inorganic arsenic (As 3+ ) was associated with bladder cancer in certain regions of Taiwan and Chile where exposure to As 3+ in drinking water > 50 µg/L (Marshall et al 2007;Chen et al 2008).…”

Section: Metallothionein Sequestration and Cadmium's Long Half-lifementioning

confidence: 99%

“…Bladder cancer risk fell by 30% in the first 4 years after smoking cessation while a further 30% reduction occurred in 20 years later (Samanic et al 2006). Such decade-long carry over effects argue that the carcinogenic agents in tobacco such as benzo(a)pyrene, tobacco specific nitrosamines that undergo rapid clearance by cytochrome P450 enzymes (Alexandrov et al 2010) may not play a key role, but those like cadmium that are retained in bladder tissues over an extended period may be causative.…”

Section: Metallothionein Sequestration and Cadmium's Long Half-lifementioning

confidence: 99%

Emerging Roles of Cadmium and Heme Oxygenase in Type-2 Diabetes and Cancer Susceptibility

Satarug

2012

Tohoku J. Exp. Med.

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Many decades after an outbreak of severe cadmium poisoning, known as Itai-itai disease, cadmium continues to pose a significant threat to human health worldwide. This review provides an update on the effects of this environmental toxicant cadmium, observed in numerous populations despite modest exposure levels. In addition, it describes the current knowledge on the link between heme catabolism and glycolysis. It examines novel functions of heme oxygenase-2 (HO-2) that protect against type 2-diabetes and obesity, which have emerged from diabetic/obese phenotypes of the HO-2 knockout mouse model. Increased cancer susceptibility in type-2 diabetes has been noted in several large cohorts. This is a cause for concern, given the high prevalence of type-2 diabetes worldwide. A lifetime exposure to cadmium is associated with pre-diabetes, diabetes, and overall cancer mortality with sex-related differences in specific types of cancer. Liver and kidney are target organs for the toxic effects of cadmium. These two organs are central to the maintenance of blood glucose levels. Further, inhibition of gluconeogenesis is a known effect of heme, while cadmium has the propensity to alter heme catabolism. This raises the possibility that cadmium may mimic certain HO-2 deficiency conditions, resulting in diabetic symptoms. Intriguingly, evidence has emerged from a recent study to suggest the potential interaction and co-regulation of HO-2 with the key regulator of glycolysis: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4). HO-2 could thus be critical to a metabolic switch to cancer-prone cells because the enzyme PFKFB and glycolysis are metabolic requirements for cell proliferation and resistance to apoptosis.

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Smoking and Bladder Cancer in Spain: Effects of Tobacco Type, Timing, Environmental Tobacco Smoke, and Gender

Cited by 156 publications

References 35 publications

Urinary Bladder Cancer Risk Factors: A Lebanese Case-Control Study

Urinary Bladder Cancer Risk Factors: A Lebanese Case-Control Study

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Emerging Roles of Cadmium and Heme Oxygenase in Type-2 Diabetes and Cancer Susceptibility

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