Smoking affects treatment outcome in patients with advanced non-small cell lung cancer

Tsao, Anne S.; Liu, D. D.; Lee, J. J.; Spitz, M. R.; Hong, Weon-Seon

doi:10.1200/jco.2004.22.14_suppl.7182

Cited by 3 publications

(4 citation statements)

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“…Exposure to tobacco in all its forms (pipes, smoking straw and/or common cigarettes) is a major risk factor, and can be reported to decrease patient survival [4], increase risk for secondary cancer [5], reduce treatment effectiveness [6][7][8][9][10][11] and decrease the quality of life. Consequently it has become increasingly associated with treatment studies in the context of smoking cancer [12].…”

Section: Introductionmentioning

confidence: 99%

Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals

et al. 2011

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The serotonergic system may be involved in smoking behavior since the intake of nicotine increases serotonin secretion in the CNS. Moreover, evidence supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible target for the understanding and elucidation of smoking behavior. The transcriptional activity of its human gene (SLC6A4) is modulated by a polymorphism described in the second intron, the STin2 VNTR, which thus may interfere with 5-HTT synthesis. In this study was analyzed the polymorphism STin2 VNTR of 60 smokers male patients diagnosed for oral carcinoma, 61 male smokers without cancer and 65 non-smoker healthy blood donors. The STin2. 9 allele carriers were more present in smoker groups (with cancer and without cancer, respectively) than in the non-smoker (OR = 7.11, 95% CI = 0.83-60.91 and OR = 24.73; IC 95% = 3.17-192.66). Conversely, individuals carrying allele 10 were more prevalent in non-smokers compared with smokers (oral cancer patients and individuals without cancer, respectively), showing a protective factor of this allele (OR = 0.56; 95% CI = 0.24-1.33 and OR = 0.46; 95% CI = 0.20-1.07). This is the first report of a study assessing the importance of STin2 VNTR smoking behavior in Brazilian individuals and the association of STin2. 9 allele carriers in nicotine dependence. It is suggested that individuals with low serotonin concentration in the central nervous system, probably due to the presence of the allele for high expression of 5-HTT,especially STin2. 9, were more susceptible to nicotine dependence. Moreover, individuals with the 10 allele might have less risk for nicotine dependence.

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Section: Introductionmentioning

confidence: 99%

Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals

et al. 2011

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“…Also, our study did not include a former smoker group. Although several studies demonstrated smoking to be an independent and significant prognostic factor of NSCLC, 14,24–26 not all studies agreed with smoking status being a prognostic factor 22,27,28 Table 6. describes such studies.…”

Section: Discussionmentioning

confidence: 99%

“…describes such studies. Different study populations and different stratification factors 22,28 may have contributed to the differing results. Thus, we conducted this study to further investigate prognostic factors for their survival in NSCLC.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors for survival in a Chinese population presenting with advanced non‐small cell lung cancer with an emphasis on smoking status: A regional, single‐institution, retrospective analysis of 4552 patients

Garfield

et al. 2012

Thoracic Cancer

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Background: Lung cancer ranks as the top of cancer-related mortality in the world. Approximately 85-90% of all lung cancer cases are non-small cell lung cancer (NSCLC). For advanced NSCLC patients, the five-year survival rate is less than 5%. Previous studies have attempted to determine prognostic factors, such as smoking status, gender, ethnicity, age, and histological type. However, the results are controversial and conflict. In this study, we investigated prognostic factors in a Chinese population presenting with advanced NSCLC. Methods: Medical records of patients with advanced NSCLC (AJCC Stage IIIB/IV) who received treatment at our institution were reviewed. Kaplan-Meier method and Cox Proportional Hazards model were performed in both univariate and multivariate analyses. Results: A total of 4552 patients were entered. Among them, 1320 (29.0%) were female, 2408 non-smokers (52.9%), and all had Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) = 0/1. Univariate analysis suggested that female gender (P < 0.001), adenocarcinoma histology (P < 0.001), age <70 (P < 0.001), and non-smoker status (P < 0.001) were associated with better survival. However, multivariate analysis demonstrated that age (hazard ratio [HR] = 1.173, 95% confidence interval [CI]: 1.085-1.268, P < 0.001), smoking status (vs. nonsmokers, HR = 1.212, 95% CI: 1.123-1.308, P < 0.001), and histological type (nonadenocarcinoma vs. adenocarcinoma, HR = 1.104, 95% CI: 1.031-1.181, P = 0.004), but not gender, were independent prognostic factors. Conclusions: Smoking status, age, and histological type are independent prognostic factors in Chinese NSCLC patients presenting with advanced disease. Nonsmoking status is associated with better overall survival in Chinese NSCLC patients.

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“…Eastern Asian ethnicity is associated with improved outcomes in those taking erlotinib or gefitinib (Thomas et al, 2006). Clinical trials also have demonstrated that patients who have a limited cigarette smoking history and those who never have smoked are more likely to respond to chemotherapy and the EGFR tyrosine kinase inhibitors (TKIs) (Miller et al, 2004;Pao et al, 2004;Tsao, Liu, Lee, Spitz, & Hong, 2006).…”

Section: Characteristics Of Non-small Cell Lung Cancermentioning

confidence: 99%

Non-Small Cell Lung Cancer: New Hope for a Chronic Illness

Tyson

2007

Oncology Nursing Forum

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Smoking affects treatment outcome in patients with advanced non-small cell lung cancer

Cited by 3 publications

References 0 publications

Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals

Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals

Prognostic factors for survival in a Chinese population presenting with advanced non‐small cell lung cancer with an emphasis on smoking status: A regional, single‐institution, retrospective analysis of 4552 patients

Non-Small Cell Lung Cancer: New Hope for a Chronic Illness

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