Smell test predicts performance on delayed recall memory test in elderly with depression

Scalco, Mônica Zavaloni; Streiner, David L.; Rewilak, Dmytro; Castel, Saulo; Reekum, Robert van

doi:10.1002/gps.2132

Cited by 6 publications

(12 citation statements)

References 34 publications

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“…At the same time, the olfactory ability measures, for example UPSIT, clearly correlate with the tools sensitive to cognitive changes in the course of dementia, such as CAMCOG [32], MMSE [13] or CVLT [31]. Moreover, taking into account a discrepancy between the severity of the neuropathological changes and cognitive deficits in a period right before death (i.e.…”

Section: Pogorszenie Funkcjonowania Węchowego W Chorobie Alzheimera Jmentioning

confidence: 93%

“…Olfactory impairment occurs early in the pre-clinical phase of AD, presenting itself ahead of cognitive and affective symptoms [1,[29][30][31][32]. Compared with the cognitive status assessment, the olfactory ability diagnosis has a few advantages: (1) olfactory tests have higher predictive/diagnostic value [33]; (2) olfactory tests are independent of patient's educational background and general cognitive status; (3) olfactory tests are easy to use.…”

Section: Olfactory Impairment Diagnosis As a Useful Marker Of The Promentioning

confidence: 99%

“…Zaburzenia węchu pojawiają się już w przedklinicznej fazie AD, wyprzedzając symptomy poznawcze i afektywne [1,[29][30][31][32]. Diagnoza sprawności węchowej w porównaniu z diagnozą sprawności poznawczej ma kilka zalet w prognozowaniu i diagnozowaniu procesu otępiennego: 1) testy sprawności węchowej mają większą wartość predykcyjną/ diagnostyczną [33], 2) są niezależne od wykształcenia i ogól-nej sprawności poznawczej oraz 3) łatwe do zastosowania.…”

Section: Diagnoza Zaburzeń Sprawności Węchowej Jako Użyteczny Biomarkunclassified

“…test UPSIT, korelują wyraźnie z miarami wrażliwymi na zmiany poznawcze w przebiegu otępienia, takimi jak CAMCOG [32], MMSE [13] czy CVLT [31]. Ponadto, uwzględniając rozbieżność między ciężkością zmian neuropatologicznych a stopniem zaawansowania deficytów poznawczych w okresie tuż przed śmiercią [tzn.…”

Section: Diagnoza Zaburzeń Sprawności Węchowej Jako Użyteczny Biomarkunclassified

“…ciated with an increased risk of cognitive status worsening and may foreshadow AD development in patients suffering from mild cognitive impairment [31]. It has been proven that the olfactory impairment correlates with worse performance on CVLT Delayed Recall task.…”

Section: Związek Sprawności Węchowej I Sprawności Poznawczejmentioning

confidence: 99%

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The olfactory dysfunctions occurring in the course of Alzheimer’s disease

Śmigórska¹,

Śmigórski²

2017

ppn

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Purpose: The aim of this article is to provide a summary of findings concerning olfactory loss associated with pathological neurodegenerative changes which occur over the course of Alzheimer's disease. Views: It is shown that compared with the healthy population, olfactory dysfunction is more pronounced in neurodegenerative diseases and precedes symptoms typical of those diseases. One of the primary differences between physiological, age-associated and pathological olfactory loss is the patients' awareness of the deficit. Healthy hyposmic or even anosmic patients are often aware of the problems caused by this dysfunction; however, it is not the case for patients in the preclinical, prodromal or clinical stages of Alzheimer's disease. Conclusions:The clinical value of olfactory function assessments should be emphasized, as it may provide information about the potential prodromal symptoms of Alzheimer's disease. Key words: Alzheimer's disease, olfaction disorders, olfactory perception, dementia, smell. StreszczenieCel: Celem pracy jest przedstawienie stanu wiedzy na temat utraty sprawności węchowej związanej z patologicznymi zmianami neurozwyrodnieniowymi zachodzącymi w przebiegu choroby Alzheimera. Poglądy: Przedstawiono dane wskazujące, że u osób cierpiących na choroby neurozwyrodnieniowe zaburzenia sprawności węcho-wej są bardziej nasilone w porównaniu ze zdrową populacją i poprzedzają objawy typowe dla tych chorób. Jedną z głównych różnic między fizjologiczną, związaną z wiekiem a patologiczną utratą węchu jest świadomość deficytu. Zdrowi, hipozmiczni lub nawet anozmiczni pacjenci są często świadomi problemów powodowanych przez dysfunkcję węchową, czego często nie stwierdza się w przypadku pacjentów w przedklinicznym, prodromalnym lub klinicznym stadium choroby Alzheimera.Wnioski: Podkreślono wartość kliniczną badania sprawności węchu jako potencjalnego objawu prodromalnego choroby Alzheimera. Słowa kluczowe: choroba Alzheimera, zaburzenia węchu, percepcja olfaktoryczna, otępienie, węch.

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Section: Pogorszenie Funkcjonowania Węchowego W Chorobie Alzheimera Jmentioning

confidence: 93%

Section: Olfactory Impairment Diagnosis As a Useful Marker Of The Promentioning

confidence: 99%

Section: Diagnoza Zaburzeń Sprawności Węchowej Jako Użyteczny Biomarkunclassified

Section: Związek Sprawności Węchowej I Sprawności Poznawczejmentioning

confidence: 99%

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The olfactory dysfunctions occurring in the course of Alzheimer’s disease

Śmigórska¹,

Śmigórski²

2017

ppn

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Current awareness in geriatric psychiatry

2009

Int J Geriat Psychiatry

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of geriatric psychiatry. Each bibliography is divided into 9 sections: 1 Reviews; 2 General; 3 Assessment; 4 Epidemiology; 5 Therapy; 6 Care; 7 Dementia; 8 Depression; 9 Psychology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted

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Association between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study

Damiano

Neto²,

Oliveira³

et al. 2022

Eur Arch Psychiatry Clin Neurosci

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Preliminary methodologically limited studies suggested that taste and smell known as chemosensory impairments and neuropsychiatric symptoms are associated in post-COVID-19. The objective of this study is to evaluate whether chemosensory dysfunction and neuropsychiatric impairments in a well-characterized post-COVID-19 sample. This is a cohort study assessing adult patients hospitalized due to moderate or severe forms of COVID-19 between March and August 2020. Baseline information includes several clinical and hospitalization data. Further evaluations were made using several different reliable instruments designed to assess taste and smell functions, parosmia, and neuropsychiatric disorders (using standardized psychiatric and cognitive measures). Out of 1800 eligible individuals, 701 volunteers were assessed on this study. After multivariate analysis, patients reporting parosmia had a worse perception of memory performance ( p < 0.001). Moderate/severe hypogeusia was significantly associated with a worse performance on the word list memory task ( p = 0.012); Concomitant moderate/severe olfactory and gustatory loss during the acute phase of COVID-19 was also significantly associated with episodic memory impairment ( p = 0.006). We found a positive association between reported chemosensory (taste and olfaction) abnormalities and cognition dysfunction in post-COVID-19 patients. These findings may help us identify potential mechanisms linking these two neurobiological functions, and also support the speculation on a possible route through which SARS-CoV-2 may reach the central nervous system. Supplementary Information The online version contains supplementary material available at 10.1007/s00406-022-01427-3.

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Smell test predicts performance on delayed recall memory test in elderly with depression

Abstract: Our results support the use of the CC-SIT as a screening tool for cognitive impairment among elderly with depression as an indicator for the need of a comprehensive neuropsychological evaluation. Replication with larger samples is necessary.

Cited by 6 publications

References 34 publications

The olfactory dysfunctions occurring in the course of Alzheimer’s disease

The olfactory dysfunctions occurring in the course of Alzheimer’s disease

Current awareness in geriatric psychiatry

Association between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study

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