Smedds Tablet: Compatability of Solid Smedds Using Various Pharmaceutical Tablet Excipients

Abstract

Objective: There are many successful products on the market which are the culmination of the self-micro-emulsification lipid technology applications. Despite the importance of lipid-based formulations, these systems have some limitations including; stability, complexity during large scale manufacturing process and limited dosage forms to such as soft gelatin capsule. In order to overcome these limitations, the prospect of converting self-micro-emulsifying drug delivery systems (SMEDDS) into tablet dosage form was investigated in this study. Methods:A self-micro-emulsifying oil formulation representing type III A lipid class composed of glycerox 767HC/croduret 40 ss at ratios of (80/20) was converted into solid SMEDDS using solid carrier adsorption method. Powder blends containing magnesium trisilicate hydrate (MTSH) or magnesium lluminum silicate (MAS) at various oil loading factors were mixed with MCC with and without various binders and compressed into tablets using a fixed loading force of approximately of 5 KN. Hardness profiles of these oil loaded tablets were then analyzed. Results:Powder compacts which contained MTSH with and without SMEDDS oil had shown relatively better compaction properties than MAS. Adding SMEDDS oil solution to either MTSH or MAS at ratios of 1:9 has relatively reduced tablets hardness by almost 2 or 4 folds, respectively. Conclusion:Progressive inclusion of increasing amounts of SMEDDS oil solution adsorbed unto the solid carrier has incurred a further reduction in the hardness of SMEDDS tablets. It appears that manufacturing of tablet SMEDDS can only be attainable for highly potent drugs as minimal amounts of oil solution added to the powder blends can adversely affect the mechanical strength of compressed tablet.

Effect of Self-Microemulsifying Lipid Formulations on the Dissolution and Compaction Profiles of Tablets Containing Theophylline; A BCS Class I Compound

“…MCC particles are plastically deformed under compaction forces to yield an extremely large number of clean surfaces brought in contact during this deformation forming a strong compact even under low compression forces (Schwartz and Lachman, 1990). Owing to its relatively high bulk and tapped density and furthermore, due to water of hydration present in its molecules, Magnesium trisilicate hydrate, as an adsorbent solid carrier, has shown relatively high compressibility with MCC than Magnesium Aluminum silicate (Hasan et al, 2016). Therefore, Magnesium trisilicate hydrate was used in this study as a solid adsorbent carrier.…”

“…ratio of added oil to the adsorbent carrier. In a recent study by Hasan et al (2016) has shown that adding as little as 4% w/w of lipidic oil to the powder compact could affect the physical strength of tablets. This is evident from Figure 5 and the contour plot depicted in Figure 6 which show a gradual and sharp drop in the hardness of compressed tablet as more amounts of lipidic SMEDDS are added to the powder mix.…”

Self-Micro Emulsifying Drug Delivery System of Ursolic Acid: Formulation Development, Characterization, Pharmacokinetic and Pharmacodynamic Studies for Diabetic Complications

“…SMEDDS boosts oral bioavailability by reducing particle size and enhancing intestinal lymphatic transit, resulting in a more interfacial surface area [11]. Low drug loading capacity, drug seeping from capsules, and stability difficulties are some of the issues with liquid SMEDDS [12]. Solidifying liquid SMEDDS removed these constraints, resulting in increased solid SMEDDS solubility, bioavailability, and stability.…”

Formulation Development of Albendazole-Loaded Self-Microemulsifying Chewable Tablets to Enhance Dissolution and Bioavailability

“…The major disadvantage of conventional SMEDDS is the high manufacturing cost as they have to be filled in soft gelatin capsules and they can interact with the shell components of the capsule in the SMEDDS. In addition, precipitation of either active ingredient and/or oil constituents can also be influenced by storage temperature [14,15]. Therefore, attention has been given to transform liquid into solid SMEDDS by several techniques such as spray drying, spray cooling, super critical fluid technology, and using adsorption carriers [14,16].…”