Formulation Development of Albendazole-Loaded Self-Microemulsifying Chewable Tablets to Enhance Dissolution and Bioavailability

Sawatdee, Somchai; Atipairin, Apichart; Yoon, Attawadee Sae; Srichana, Teerapol; Changsan, Narumon; Suwandecha, Tan

doi:10.3390/pharmaceutics11030134

Cited by 42 publications

(23 citation statements)

References 38 publications

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“…28 In addition, to improving the solubility and dissolution rate of waterinsoluble agents, SMEDDS also can enhance intestinal permeability and provide a greater interfacial absorption area, thereby improving the bioavailability of agents. [29][30][31] In the interest of enhancing the solubility and in vivo availability of ILQ, we sought to design a formulation based on self-micro-emulsifying drug delivery system (SMEEDS) for oral administration of ILQ. In this study, we optimized the formulation of ILQ-SMEDDS and evaluated its appearance, mean globule size, zeta potential and morphology.…”

Section: Introductionmentioning

confidence: 99%

<p>Development of an Orally Bioavailable Isoliquiritigenin Self-Nanoemulsifying Drug Delivery System to Effectively Treat Ovalbumin-Induced Asthma</p>

Cao¹,

Zhan²,

Wang³

et al. 2020

IJN

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Section: Introductionmentioning

confidence: 99%

<p>Development of an Orally Bioavailable Isoliquiritigenin Self-Nanoemulsifying Drug Delivery System to Effectively Treat Ovalbumin-Induced Asthma</p>

Cao¹,

Zhan²,

Wang³

et al. 2020

IJN

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“…The time course of plasma concentrations of THAP in dogs may suggest that THAP is absorbed twice in the stomach as well as in the upper small intestine region. Considering the time needed for a tablet to be disintegrated, the IR tablet dosage form absorbed twice in two different areas of the gastrointestinal tract may result in the double-peak phenomenon [ 17 , 18 ]. Similarly, a slightly doubled peak was also observed at the highest dose group of THAP in rats (750 mg/kg).…”

Section: Resultsmentioning

confidence: 99%

Development and Validation of an LC-MS/MS Assay to Quantitate 2′,4′,6′-Trihydroxyacetophenone in Rat and Dog Plasma and its Application to a Pharmacokinetic Study

et al. 2020

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In the present study, a simple, rapid, and reliable bioanalytical method was developed using liquid chromatography with tandem-mass spectrometry (LC-MS/MS) to quantify 2′,4′,6′-trihydroxyacetophenone (THAP) in rat and dog plasma with 2′,4′,6′-trihydroxybenzaldehyde as an internal standard (IS). The LC-MS/MS instrument was operated in the multiple reaction monitoring (MRM) mode to detect THAP at m/z transition 166.89 > 82.8 and IS at 152.89 > 82.8, respectively. A simple, one-step protein precipitation (PP) method was employed with acetonitrile for sample preparation. Utilizing a Gemini C18 column, THAP and IS were separated with an isocratic mobile phase consisting of 10 mM ammonium acetate and methanol (10:90, v/v) at a flow rate of 0.2 mL/min. Total chromatographic run time was 2.5 min per sample injection. The standard calibration curve for THAP was linear (r2 ≥ 0.9987) over the concentration range of 0.1 to 100 µg/mL with the lower limit of quantitation (LLOQ) of 0.1 µg/mL (S/N ratio > 10). According to the regulatory guidelines from the U.S. Food and Drug Administration (FDA) and the Korea Ministry of Food and Drug Safety (MFDS), our newly developed biomedical analytical method was fully and adequately validated in terms of selectivity, sensitivity, linearity, intra- and inter-day precision and accuracy, recovery, matrix effect, stability, and dilution integrity. Our validated assay was successfully utilized in a nonclinical pharmacokinetic study of THAP in rats and dogs.

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“…Lacosamide, Microcrystalline Cellulose, Aspartame and the super disintegrants were properly mixed for 30min in a suitable container to obtain a uniform blend. The blend was further lubricated with magnesium stearate and talc for 5min 3 .…”

Section: Formulation Of Lacosamide Fast Dissolving Tabletsmentioning

confidence: 99%

“…They occur when a sudden imbalance occurs between the excitatory and inhibitory forces within the network of cortical neurons. Cell membrane instability or its physiological changes in its adjacent supporting cells represent the main pathophysiology of seizures 3 . The fast-dissolving tablets release the medicament in the mouth for absorption through local oro-mucosal tissue and through pre-gastric (oral cavity, pharynx and oesophagus), gastric (stomach) and postgastric (small and large intestine) segments of the Gastro-Intestinal Tract.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Fast Dissolving Tablets of Antiepileptic Drug

Akhtar¹

2020

Univ J Pharm Res

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The objective of the present study was to prepare and evaluate the mouth dissolving tablet of lacosamide using super disintegrants like Guar Gum, and other excipients like microcrystalline cellulose and mannitol in different concentrations by direct compression method. Lacosamide has been shown to be an effective antiepileptic agent appropriate for epilepsy patients. The mouth dissolving tablets were prepared by a single punch machine using a powder blend of super disintegrants and lacosamide. Post-compression parameters like hardness, weight variation, friability, in-vitro dispersion, drug content uniformity, and in-vitro drug release studies were carried out for all formulations. All formulations results were within official limits. Fast disintegration time obtained between 35 sec. and 128 sec, was within the official limit. Different drug release kinetic models were applied for selecting batches for stability studies. These showed that there was no significant change in residual drug content in mouth dissolving tablets. By the in-vitro disintegration, it is concluded that formulation prepared by Guar Gum (10%) showed faster disintegration time than that of MCC. This indicates that the use of super disintegrants increases the release of drug from the formulation. Therefore, it can be concluded that such mouth dissolving tablets are suitable delivery systems for lacosamide. Peer Review History: UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 3.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Name: Dr. Iman Muhammad Higazy Affiliation: National Research Center, Egypt E-mail: imane.higazy@hotmail.com Name: Dr. Mohamed Salama Affiliation: Modern University for Technology & Information, Egypt E-mail: salama47@yahoo.com Comments of reviewer(s): Similar Articles: FAST DISSOLVING DRUG DELIVERY SYSTEMS: FORMULATION, PREPARATION TECHNIQUES AND EVALUATION FAST DISSOLVING TABLETS: A PROMISING APPROACH FOR DRUG DELIVERY DEVELOPMENT AND EVALUATION OF FAST DISSOLVING THIN FILMS OF ARIPIPRAZOLE

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Formulation Development of Albendazole-Loaded Self-Microemulsifying Chewable Tablets to Enhance Dissolution and Bioavailability

Cited by 42 publications

References 38 publications

<p>Development of an Orally Bioavailable Isoliquiritigenin Self-Nanoemulsifying Drug Delivery System to Effectively Treat Ovalbumin-Induced Asthma</p>

<p>Development of an Orally Bioavailable Isoliquiritigenin Self-Nanoemulsifying Drug Delivery System to Effectively Treat Ovalbumin-Induced Asthma</p>

Development and Validation of an LC-MS/MS Assay to Quantitate 2′,4′,6′-Trihydroxyacetophenone in Rat and Dog Plasma and its Application to a Pharmacokinetic Study

Formulation and Evaluation of Fast Dissolving Tablets of Antiepileptic Drug

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